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DRAM1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242182

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various… More details

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Product Overview

Product Name
DRAM1 / DRAM, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human DRAM1 / DRAM
Product Gene Name
Product Synonym Gene Name
DRAM
Product Synonym Names
Anti-DRAM1 / DRAM Antibody (C-Terminus) IHC-plus; DRAM1; DRAM; Human DRAM1; DRAM
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
16 amino acid peptide from near the carboxy terminus of human DRAM.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
13,972 Da
OMIM
610776
3D Structure
ModBase 3D Structure for Q8N682
Target Species
Human
Immunogen Description
Synthetic peptide from human DRAM1 / DRAM.
Immunogen Type
Synthetic peptide
Immunogen
DRAM1 / DRAM antibody was raised against synthetic peptide from human DRAM1 / DRAM.
Antigen Modification
C-Terminus

Product Categories/Family for anti-DRAM1 antibody

Applications Tested/Suitable for anti-DRAM1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-DRAM1 antibody
ELISA, IHC-P (3 ug/ml), WB (0.5 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-DRAM1 antibody

Anti-DRAM1 / DRAM antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.
Rabbit Anti-DRAM1 Polyclonal Antibody – Cat# MBS242182

Immunofluorescence (IF) of anti-DRAM1 antibody

Immunofluorescence of DRAM in Human Liver cells with DRAM antibody at 20 ug/ml.
Rabbit Anti-DRAM1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS242182

Western Blot (WB) of anti-DRAM1 antibody

Western blot of DRAM in 293 cell lysate with DRAM antibody at (A) 0.5 and (B) 1 ug/ml.
Rabbit Anti-DRAM1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS242182

Other Notes

Small volumes of anti-DRAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DRAM1 purchase

MBS242182 is an antibody targeting DRAM1. Also known as Rabbit Polyclonal to Human DRAM1 / DRAM. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DRAM1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
DNA damage-regulated autophagy modulator protein 1
NCBI Official Synonym Full Names
DNA-damage regulated autophagy modulator 1
NCBI Official Symbol
DRAM1
NCBI Official Synonym Symbols
DRAM
UniProt Protein Name
DNA damage-regulated autophagy modulator protein 1
UniProt Synonym Protein Names
Damage-regulated autophagy modulator
UniProt Gene Name
DRAM1
UniProt Synonym Gene Names
DRAM
UniProt Entry Name
DRAM1_HUMAN
NCBI Protein Information
DNA damage-regulated autophagy modulator protein 1

UniProt Comments for DRAM1

DRAM1: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy. Belongs to the DRAM/TMEM150 family.

Protein type: Apoptosis; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: lysosome; lysosomal membrane; cytoplasm; integral to membrane

Biological Process: apoptosis; autophagy; regulation of autophagy
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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