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ANXA11 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242189

The annexins are a family of calcium-dependent phospholipid-binding proteins; similar to other annexins in the conserved C-terminal domain. More details

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Product Overview

Product Name
ANXA11 / Annexin XI, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human ANXA11 / Annexin XI
Product Gene Name
anti-ANXA11 antibody
Product Synonym Names
Anti-ANXA11 / Annexin XI Antibody (N-Terminus) IHC-plus; ANXA11; 56 kDa autoantigen; Annexin A11; Annexin XI; CAP-50; Annexin-11; ANX11; Autoantigen; 56-kD; CAP50; Human ANXA11; Annexin XI
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Gorilla, Human, Monkey, Rabbit
Predicted Reactivity: Mouse, Rat, Bovine, Dog, Hamster, Pig (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human ANXA11 / Annexin A11. NP_001148.1; NP_665875.1 and NP_665876.1 are varients that encode the same protein.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
51,242 Da
OMIM
602572
3D Structure
ModBase 3D Structure for P50995
Target Species
Human
Immunogen Description
Synthetic peptide YPGYPPPPGGYPP-C from the N-terminus of human ANXA11 / Annexin A11 (NP_001148.1; NP_665875.1; NP_665876.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Rabbit (100%).
Immunogen Type
Synthetic peptide
Immunogen
ANXA11 / Annexin XI antibody was raised against synthetic peptide YPGYPPPPGGYPP-C from the N-terminus of human ANXA11 / Annexin A11 (NP_001148.1; NP_665875.1; NP_665876.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Rabbit (100%); Mouse, Rat, Hamster, Elephant, Dog, Bovine, Pig, Platypus (92%); Monkey, Horse, Opossum, Salmon, Stickleback, Pufferfish (85%).
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-ANXA11 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-ANXA11 antibody
ELISA (1:32000), IHC-P (3.75 ug/ml), WB (0.2 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-ANXA11 antibody

Anti-Annexin A11 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
Goat Anti-ANXA11 Polyclonal Antibody – Cat# MBS242189

Western Blot (WB) of anti-ANXA11 antibody

Antibody staining (0.2 ug/ml) of HeLa lysate (RIPA buffer, 30 ug total protein/per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
Goat Anti-ANXA11 Polyclonal Antibody, Western Blot (WB) – Cat# MBS242189

Other Notes

Small volumes of anti-ANXA11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANXA11 purchase

MBS242189 is an antibody targeting ANXA11. Also known as Goat Polyclonal to Human ANXA11 / Annexin XI. Reactive in Gibbon, Gorilla, Human, Monkey, Rabbit
Predicted Reactivity: Mouse, Rat, Bovine, Dog, Hamster, Pig (at least 90% immunogen sequence identity). Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for ANXA11. It may not necessarily be applicable to this product.

NCBI GI #
4557317
NCBI GeneID
311
NCBI Accession #
NP_001148.1
UniProt Primary Accession #
P50995
UniProt Secondary Accession #
B4DVE7
UniProt Related Accession #
P50995
GenBank Nucleotide #
NM_001157.2
NCBI Official Full Name
annexin A11 isoform 1
NCBI Official Synonym Full Names
annexin A11
NCBI Official Symbol
ANXA11
NCBI Official Synonym Symbols
ANX11; CAP50
UniProt Protein Name
Annexin A11
UniProt Synonym Protein Names
56 kDa autoantigen; Annexin XI; Annexin-11; Calcyclin-associated annexin 50; CAP-50
Protein Family
Annexin
UniProt Gene Name
ANXA11
UniProt Synonym Gene Names
ANX11; CAP-50
UniProt Entry Name
ANX11_HUMAN
NCBI Protein Information
annexin A11; CAP-50; annexin XI; annexin-11; 56 kDa autoantigen; autoantigen, 56-kD; calcyclin-associated annexin 50

NCBI Summary for ANXA11

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, May 2013]
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UniProt Comments for ANXA11

ANXA11: a calcium/phospholipid-binding protein found throughout the nucleoplasm at interphase and at the mitotic phase is concentrated at the loop-like structure around the mitotic apparatus. May interact with calcyclin (S100A6) in vivo. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Lipid-binding; Nuclear envelope; Motility/polarity/chemotaxis; Calcium-binding

Chromosomal Location of Human Ortholog: 10q23

Cellular Component: nucleoplasm; azurophil granule; specific granule; membrane; cytoplasm; melanosome; spindle; nuclear envelope; midbody; phagocytic vesicle

Molecular Function: protein binding; calcium-dependent phospholipid binding; phosphatidylethanolamine binding; calcium ion binding; calcium-dependent protein binding

Biological Process: response to calcium ion; phagocytosis
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Research Articles on ANXA11

1. the associations of Anxa11 with Ca(2+)-regulated exocytosis, cytokinesis, sex differentiation, autoimmune diseases, thrombolysis and cancers are summarized--{REVIEW}

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ANXA11 antibody

 Reference Product  PubMed Publications
 S100A6 antibody  >3 publications with ANXA11 and S100A6

Diseases associated with anti-ANXA11 antibody

 Disease Name  Pubmed Publications
 Sarcoidosis Antibodies  >10 publications with ANXA11 and Sarcoidosis
 Neoplasm Metastasis Antibodies  >2 publications with ANXA11 and Neoplasm Metastasis
 Neural Tube Defects Antibodies  >1 publications with ANXA11 and Neural Tube Defects
 Disease Models, Animal Antibodies  >1 publications with ANXA11 and Disease Models, Animal
 Brain Diseases Antibodies  >1 publications with ANXA11 and Brain Diseases
 Inflammation Antibodies  >1 publications with ANXA11 and Inflammation
 Necrosis Antibodies  >1 publications with ANXA11 and Necrosis

Organs/Tissues associated with anti-ANXA11 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with ANXA11 and Lung
 Embryonic Tissue Antibodies  >1 publications with ANXA11 and Embryonic Tissue
 Bone Antibodies  >1 publications with ANXA11 and Bone
 Muscle Antibodies  >1 publications with ANXA11 and Muscle
 Eye Antibodies  >1 publications with ANXA11 and Eye
 Connective Tissue Antibodies  >1 publications with ANXA11 and Connective Tissue
 Kidney Antibodies  >1 publications with ANXA11 and Kidney
 Testis Antibodies  >1 publications with ANXA11 and Testis
 Skin Antibodies  >1 publications with ANXA11 and Skin
 Vascular Antibodies  >1 publications with ANXA11 and Vascular
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