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SLC22A17 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242338

MBS242338 is an antibody targeting SLC22A17. Also known as Goat Polyclonal to Human SLC22A17. Reactive in Bat, Gibbon, Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, RatPredicted Reactivity: Rabbit (at least 90% immunogen sequence identity).… More details

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Product Overview

Product Name
SLC22A17, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human SLC22A17
Product Gene Name
anti-SLC22A17 antibody
Product Synonym Names
Anti-SLC22A17 Antibody (Internal) IHC-plus; SLC22A17; 24p3 receptor; 24p3R; BOIT; BOCT; HBOIT; NGALR; NGAL receptor; NGALR2; Lipocalin-2 receptor; MBOCT; NGALR3; Human SLC22A17
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Gibbon, Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat
Predicted Reactivity: Rabbit (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human SLC22A17. This antibody is expected to recognize both reported isoforms NP_065105.2 and NP_057693.3).
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
21,712 Da
OMIM
611461
3D Structure
ModBase 3D Structure for Q8WUG5
Target Species
Human
Immunogen Description
Synthetic peptide C-PETKRKLLPEVLRD from an internal region of human SLC22A17 (NP_065105.2; NP_057693.3). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Panda, Dog, Bat, Bovine, Horse, Pig (100%).
Immunogen Type
Synthetic peptide
Immunogen
SLC22A17 antibody was raised against synthetic peptide C-PETKRKLLPEVLRD from an internal region of human SLC22A17 (NP_065105.2; NP_057693.3). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Panda, Dog, Bat, Bovine, Horse, Pig (100%); Elephant, Rabbit (93%).
Antigen Modification
Internal

Product Categories/Family for anti-SLC22A17 antibody

Family: Transporter; Subfamily: Organic cation transporter
Applications Tested/Suitable for anti-SLC22A17 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-SLC22A17 antibody
ELISA (1:64000), IHC-P (2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-SLC22A17 antibody

Anti-SLC22A17 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
Goat Anti-SLC22A17 Polyclonal Antibody – Cat# MBS242338

Immunohistochemistry (IHC) of anti-SLC22A17 antibody

Anti-SLC22A17 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
Goat Anti-SLC22A17 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242338

Other Notes

Small volumes of anti-SLC22A17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC22A17. It may not necessarily be applicable to this product.

NCBI GI #
21361834
NCBI GeneID
51310
NCBI Accession #
NP_065105.2
UniProt Primary Accession #
Q8WUG5
UniProt Secondary Accession #
Q2TAB0; Q5BKY8; Q86U04; Q9H1D3; Q9NQD5; A4UA13; A8MUT0
UniProt Related Accession #
Q8WUG5
GenBank Nucleotide #
NM_020372.3
NCBI Official Full Name
solute carrier family 22 member 17 isoform a
NCBI Official Synonym Full Names
solute carrier family 22, member 17
NCBI Official Symbol
SLC22A17
NCBI Official Synonym Symbols
BOCT; BOIT; 24p3R; NGALR; hBOIT; NGALR2; NGALR3
UniProt Protein Name
Solute carrier family 22 member 17
UniProt Synonym Protein Names
24p3 receptor; 24p3R; Brain-type organic cation transporter; Lipocalin-2 receptor; Neutrophil gelatinase-associated lipocalin receptor; NgalR
Protein Family
Solute carrier family
UniProt Gene Name
SLC22A17
UniProt Synonym Gene Names
BOCT; BOIT; 24p3R; NgalR
UniProt Entry Name
S22AH_HUMAN
NCBI Protein Information
solute carrier family 22 member 17; 24p3 receptor; NGAL receptor; lipocalin-2 receptor; brain-type organic cation transporter; potent brain type organic ion transporter; neutrophil gelatinase-associated lipocalin receptor; solute carrier family 22 (organic cation transporter), member 17

UniProt Comments for SLC22A17

SLC22A17: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: integral to plasma membrane; vacuolar membrane

Molecular Function: transmembrane receptor activity; transmembrane transporter activity

Biological Process: cellular iron ion homeostasis; siderophore transport; ion transport; signal transduction; transmembrane transport
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Research Articles on SLC22A17

1. No significant difference was found in the expressions of NGALR mRNA in placenta among moderate preeclampsia group, severe preeclampsia group and control group.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC22A17 antibody

 Reference Product  PubMed Publications
 LCN2 antibody  >9 publications with SLC22A17 and LCN2

Pathways associated with anti-SLC22A17 antibody

 Products by Pathway  Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Orphan Transporters Pathway antibodies  Orphan Transporters Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-SLC22A17 antibody

 Disease Name  Pubmed Publications
 Liver Neoplasms Antibodies  >2 publications with SLC22A17 and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with SLC22A17 and Liver Diseases
 Renal Insufficiency Antibodies  >1 publications with SLC22A17 and Renal Insufficiency
 Acute Kidney Injury Antibodies  >1 publications with SLC22A17 and Acute Kidney Injury
 Carcinoma, Hepatocellular Antibodies  >1 publications with SLC22A17 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >1 publications with SLC22A17 and Kidney Diseases
 Disease Models, Animal Antibodies  >1 publications with SLC22A17 and Disease Models, Animal

Organs/Tissues associated with anti-SLC22A17 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with SLC22A17 and Blood
 Brain Antibodies  >4 publications with SLC22A17 and Brain
 Vascular Antibodies  >2 publications with SLC22A17 and Vascular
 Kidney Antibodies  >1 publications with SLC22A17 and Kidney
 Uterus Antibodies  >1 publications with SLC22A17 and Uterus
 Heart Antibodies  >1 publications with SLC22A17 and Heart
 Placenta Antibodies  >1 publications with SLC22A17 and Placenta
 Lung Antibodies  >1 publications with SLC22A17 and Lung
 Embryonic Tissue Antibodies  >1 publications with SLC22A17 and Embryonic Tissue
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