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ADCYAP1R1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242350

The PACAP receptor type 1, a member of the vasoactive intestinal polypeptide subfamily, binds the hormone pituitary adenylate cyclase activating polypeptide (PACAP) with high affinity. PACAP is involved in stimulating the secretion of insulin, catecholamines,… More details

$650 / 0.05 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
ADCYAP1R1 / PAC1 Receptor, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human ADCYAP1R1 / PAC1 Receptor
Product Gene Name
anti-ADCYAP1R1 antibody
Product Synonym Names
Anti-ADCYAP1R1 / PAC1 Receptor Antibody (N-Terminus) IHC-plus; PAC1; Pac1 receptor; Pac1 receptors; PAC1-R; PACAP receptor 1; Pacap specific receptor; PACAP-R-1; PACAP/VIP receptors; PACAP1 receptor; PACAP Receptor; Pacap receptor type 1; Pacap type 1 receptor; PACAP type I receptor; PACAPR; PAC1R; Human ADCYAP1R1; PAC1 Receptor
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human, Monkey
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human ADCYAP1R1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
46,957 Da
OMIM
102981
3D Structure
ModBase 3D Structure for P41586
Target Species
Human
Immunogen Description
Synthetic 18 amino acid peptide from N-terminal extracellular domain of human ADCYAP1R1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Elephant, Panda, Horse, Pig (89%); Bovine (83%).
Immunogen Type
Synthetic peptide
Immunogen
ADCYAP1R1 / PAC1 Receptor antibody was raised against synthetic 18 amino acid peptide from N-terminal extracellular domain of human ADCYAP1R1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Elephant, Panda, Horse, Pig (89%); Bovine (83%).
Antigen Modification
N-Terminus

Product Categories/Family for anti-ADCYAP1R1 antibody

Family: GPCR; Subfamily: Vasoactive intestinal polypeptide
Applications Tested/Suitable for anti-ADCYAP1R1 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-ADCYAP1R1 antibody
ELISA, IHC-P (5 - 7 ug/ml)
Usage: Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.

Immunohistochemistry (IHC) of anti-ADCYAP1R1 antibody

Anti-ADCYAP1R1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-ADCYAP1R1 Polyclonal Antibody – Cat# MBS242350

Immunohistochemistry (IHC) of anti-ADCYAP1R1 antibody

Anti-ADCYAP1R1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-ADCYAP1R1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242350

Other Notes

Small volumes of anti-ADCYAP1R1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADCYAP1R1 purchase

MBS242350 is an antibody targeting ADCYAP1R1. Also known as Rabbit Polyclonal to Human ADCYAP1R1 / PAC1 Receptor. Reactive in Gibbon, Gorilla, Human, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ADCYAP1R1. It may not necessarily be applicable to this product.

NCBI GI #
29171759
NCBI GeneID
117
NCBI Accession #
NP_001109.2
UniProt Primary Accession #
P41586
UniProt Secondary Accession #
Q17S10; A8K1Y1; B7ZLA7; B8ZZK3
UniProt Related Accession #
P41586
GenBank Nucleotide #
NM_001118.4
NCBI Official Full Name
pituitary adenylate cyclase-activating polypeptide type I receptor isoform 3
NCBI Official Synonym Full Names
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
NCBI Official Symbol
ADCYAP1R1
NCBI Official Synonym Symbols
PAC1; PAC1R; PACAPR; PACAPRI
UniProt Protein Name
Pituitary adenylate cyclase-activating polypeptide type I receptor
Protein Family
Pituitary adenylate cyclase-activating polypeptide type I receptor
UniProt Gene Name
ADCYAP1R1
UniProt Synonym Gene Names
PACAP type I receptor; PACAP-R-1; PACAP-R1
UniProt Entry Name
PACR_HUMAN
NCBI Protein Information
pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP-R1; PACAP receptor 1; PACAP type I receptor; pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop

NCBI Summary for ADCYAP1R1

This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
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UniProt Comments for ADCYAP1R1

ADCYAP1R1: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. Belongs to the G-protein coupled receptor 2 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 7p14

Cellular Component: neuron projection; tight junction; cell surface; rough endoplasmic reticulum; integral to plasma membrane; plasma membrane; caveola; endosome; receptor complex

Molecular Function: neuropeptide binding; ADP-ribosylation factor binding; vasoactive intestinal polypeptide receptor activity; protein binding; receptor activity; adenylate cyclase binding

Biological Process: response to drug; development of primary female sexual characteristics; nerve growth factor receptor signaling pathway; adenylate cyclase activation; response to estradiol stimulus; G-protein coupled receptor protein signaling pathway; cAMP-mediated signaling; response to ethanol; cell surface receptor linked signal transduction; phospholipase C activation; spermatogenesis; cell differentiation; multicellular organismal response to stress; transmembrane receptor protein tyrosine kinase signaling pathway
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Research Articles on ADCYAP1R1

1. PAC1/PACAP receptor endocytosis contributes to ERK acktivation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ADCYAP1R1 antibody

 Reference Product  PubMed Publications
 ADCYAP1 antibody  >104 publications with ADCYAP1R1 and ADCYAP1
 CRH antibody  >2 publications with ADCYAP1R1 and CRH
 GHRH antibody  >2 publications with ADCYAP1R1 and GHRH
 POMC antibody  >1 publications with ADCYAP1R1 and POMC

Pathways associated with anti-ADCYAP1R1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of TRKA Receptors Pathway antibodies  Activation Of TRKA Receptors Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram

Diseases associated with anti-ADCYAP1R1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >6 publications with ADCYAP1R1 and Breast Neoplasms
 Inflammation Antibodies  >5 publications with ADCYAP1R1 and Inflammation
 Kidney Diseases Antibodies  >3 publications with ADCYAP1R1 and Kidney Diseases
 Disease Models, Animal Antibodies  >2 publications with ADCYAP1R1 and Disease Models, Animal
 Learning Disorders Antibodies  >2 publications with ADCYAP1R1 and Learning Disorders
 Hyperplasia Antibodies  >2 publications with ADCYAP1R1 and Hyperplasia
 Brain Injuries Antibodies  >2 publications with ADCYAP1R1 and Brain Injuries
 Liver Neoplasms, Experimental Antibodies  >2 publications with ADCYAP1R1 and Liver Neoplasms, Experimental
 Liver Diseases Antibodies  >2 publications with ADCYAP1R1 and Liver Diseases
 Hypertrophy Antibodies  >2 publications with ADCYAP1R1 and Hypertrophy

Organs/Tissues associated with anti-ADCYAP1R1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >76 publications with ADCYAP1R1 and Brain
 Nerve Antibodies  >28 publications with ADCYAP1R1 and Nerve
 Pituitary Gland Antibodies  >26 publications with ADCYAP1R1 and Pituitary Gland
 Blood Antibodies  >15 publications with ADCYAP1R1 and Blood
 Ganglia Antibodies  >14 publications with ADCYAP1R1 and Ganglia
 Muscle Antibodies  >12 publications with ADCYAP1R1 and Muscle
 Adrenal Gland Antibodies  >11 publications with ADCYAP1R1 and Adrenal Gland
 Lung Antibodies  >10 publications with ADCYAP1R1 and Lung
 Kidney Antibodies  >6 publications with ADCYAP1R1 and Kidney
 Intestine Antibodies  >5 publications with ADCYAP1R1 and Intestine
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