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SNCG Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242356

Synuclein-gamma is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between… More details

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Product Overview

Product Name
SNCG / Gamma-Synuclein, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human SNCG / Gamma-Synuclein
Product Gene Name
anti-SNCG antibody
Product Synonym Names
Anti-SNCG / Gamma-Synuclein Antibody IHC-plus; SNCG; BCSG1; Gamma-synuclein; PRSN; SR; PERSYN; Synoretin; Human SNCG; Gamma-Synuclein
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, pH 7.4, 0.1% sodium azide
Purity/Purification
Protein A Purified
Specificity
This antibody is specific for gamma-synuclein and does not cross-react with alpha- and beta-synuclein.
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
Molecular Weight
13,331 Da
OMIM
602998
3D Structure
ModBase 3D Structure for O76070
Target Species
Human
Immunogen Description
Recombinant human gamma-Synuclein purified from E Coli.
Immunogen Type
Recombinant protein
Immunogen
SNCG / Gamma-Synuclein antibody was raised against recombinant human gamma-Synuclein purified from E Coli.
Applications Tested/Suitable for anti-SNCG antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-SNCG antibody
ELISA, IHC-P (5 ug/ml), WB (1:500 - 1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-SNCG antibody

Anti-SNCG antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-SNCG Polyclonal Antibody – Cat# MBS242356

Immunohistochemistry (IHC) of anti-SNCG antibody

Anti-SNCG antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-SNCG Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242356

Western Blot (WB) of anti-SNCG antibody

The recombinant synuclein family (alpha-, beta- and gamma-) and the extracts of HT-29 (colon adenocarcinoma) cells were resolved by SDS-PAGE, transferred to PVDF membrane and probed with polyclonal anti-human gamma-synuclein(1:1000). Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP and the ECL detection system.
Rabbit Anti-SNCG Polyclonal Antibody, Western Blot (WB) – Cat# MBS242356

Other Notes

Small volumes of anti-SNCG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNCG purchase

MBS242356 is an antibody targeting SNCG. Also known as Rabbit Polyclonal to Human SNCG / Gamma-Synuclein. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SNCG. It may not necessarily be applicable to this product.

NCBI GI #
209693439
NCBI GeneID
6623
NCBI Accession #
NP_003078.2
UniProt Primary Accession #
O76070
UniProt Secondary Accession #
O15104; Q96P61
UniProt Related Accession #
O76070
GenBank Nucleotide #
NM_003087.2
NCBI Official Full Name
gamma-synuclein
NCBI Official Synonym Full Names
synuclein, gamma (breast cancer-specific protein 1)
NCBI Official Symbol
SNCG
NCBI Official Synonym Symbols
SR; BCSG1
UniProt Protein Name
Gamma-synuclein
UniProt Synonym Protein Names
Breast cancer-specific gene 1 protein; Persyn; Synoretin; SR
Protein Family
Gamma-synuclein
UniProt Gene Name
SNCG
UniProt Synonym Gene Names
BCSG1; PERSYN; PRSN; SR
UniProt Entry Name
SYUG_HUMAN
NCBI Protein Information
gamma-synuclein; persyn; synoretin; breast cancer-specific gene 1 protein

NCBI Summary for SNCG

This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]

UniProt Comments for SNCG

SNCG: a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. May be involved in modulating axonal architecture during development and in the adult. Plays a role in neurofilament network integrity. High levels have been identified in advanced breast carcinomas.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 10q23.2-q23.3

Cellular Component: cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; microtubule organizing center; spindle; nerve terminal

Molecular Function: beta-tubulin binding; alpha-tubulin binding

Biological Process: response to drug; synaptic transmission; adult locomotory behavior; synapse organization and biogenesis; regulation of neurotransmitter secretion; protein secretion; response to cocaine; regulation of dopamine secretion
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Research Articles on SNCG

1. These data show that SNCG renders AMD resistance by inhibiting BubR1 activity and attenuating SAC function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SNCG antibody

 Reference Product  PubMed Publications
 EXT2 antibody  >1 publications with SNCG and EXT2
 FABP4 antibody  >1 publications with SNCG and FABP4

Diseases associated with anti-SNCG antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >36 publications with SNCG and Breast Neoplasms
 Carcinoma Antibodies  >27 publications with SNCG and Carcinoma
 Nervous System Diseases Antibodies  >15 publications with SNCG and Nervous System Diseases
 Adenocarcinoma Antibodies  >15 publications with SNCG and Adenocarcinoma
 Liver Neoplasms Antibodies  >8 publications with SNCG and Liver Neoplasms
 Movement Disorders Antibodies  >7 publications with SNCG and Movement Disorders
 Disease Models, Animal Antibodies  >5 publications with SNCG and Disease Models, Animal
 Liver Diseases Antibodies  >5 publications with SNCG and Liver Diseases
 Neoplasms, Experimental Antibodies  >4 publications with SNCG and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >3 publications with SNCG and Lung Neoplasms

Organs/Tissues associated with anti-SNCG antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >32 publications with SNCG and Nerve
 Brain Antibodies  >12 publications with SNCG and Brain
 Liver Antibodies  >11 publications with SNCG and Liver
 Eye Antibodies  >6 publications with SNCG and Eye
 Prostate Antibodies  >5 publications with SNCG and Prostate
 Lung Antibodies  >5 publications with SNCG and Lung
 Ovary Antibodies  >3 publications with SNCG and Ovary
 Bladder Antibodies  >3 publications with SNCG and Bladder
 Adipose Tissue Antibodies  >2 publications with SNCG and Adipose Tissue
 Muscle Antibodies  >2 publications with SNCG and Muscle
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