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BHMT Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242384

Betaine-homocysteine methyltransferase is a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in BHMT could lead to hyperhomocyst(e)inemia, but such a defect has not yet been… More details

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Product Overview

Product Name
BHMT, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human BHMT
Product Gene Name
anti-BHMT antibody
Product Synonym Names
Anti-BHMT Antibody (C-Terminus) IHC-plus; BHMT; BHMT1; Human BHMT
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Gorilla, Hamster, Human, Monkey, Orangutan, Rat
Predicted Reactivity: Mouse, Bat, Bovine, Dog, Horse, Pig, Chicken (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human BHMT.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
44,998 Da
OMIM
602888
3D Structure
ModBase 3D Structure for Q93088
Target Species
Human
Immunogen Description
Synthetic peptide C-EQQLKELFEKQK from the C-terminus of human BHMT (NP_001704.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Hamster, Panda (100%).
Immunogen Type
Synthetic peptide
Immunogen
BHMT antibody was raised against synthetic peptide C-EQQLKELFEKQK from the C-terminus of human BHMT (NP_001704.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Hamster, Panda (100%); Mouse, Dog, Bat, Bovine, Horse, Pig, Opossum, Chicken (92%); Rat, Elephant, Rabbit (83%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-BHMT antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-BHMT antibody
ELISA (1:16000), IHC-P (2.5 ug/ml), WB (0.03 - 0.1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-BHMT antibody

Anti-BHMT antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-BHMT Polyclonal Antibody – Cat# MBS242384

Immunohistochemistry (IHC) of anti-BHMT antibody

Anti-BHMT antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-BHMT Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242384

Western Blot (WB) of anti-BHMT antibody

Antibody (0.03 ug/ml) staining of Rat Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-BHMT Polyclonal Antibody, Western Blot (WB) – Cat# MBS242384

Other Notes

Small volumes of anti-BHMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BHMT purchase

MBS242384 is an antibody targeting BHMT. Also known as Goat Polyclonal to Human BHMT. Reactive in Gibbon, Gorilla, Hamster, Human, Monkey, Orangutan, Rat
Predicted Reactivity: Mouse, Bat, Bovine, Dog, Horse, Pig, Chicken (at least 90% immunogen sequence identity). Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for BHMT. It may not necessarily be applicable to this product.

NCBI GI #
157266337
NCBI GeneID
635
NCBI Accession #
NP_001704.2
UniProt Primary Accession #
Q93088
UniProt Secondary Accession #
Q9UNI9
UniProt Related Accession #
Q93088
GenBank Nucleotide #
NM_001713.2
NCBI Official Full Name
betaine--homocysteine S-methyltransferase 1
NCBI Official Synonym Full Names
betaine--homocysteine S-methyltransferase
NCBI Official Symbol
BHMT
NCBI Official Synonym Symbols
BHMT1; HEL-S-61p
UniProt Protein Name
Betaine--homocysteine S-methyltransferase 1
Protein Family
Betaine--homocysteine S-methyltransferase
UniProt Gene Name
BHMT
UniProt Entry Name
BHMT1_HUMAN
NCBI Protein Information
betaine--homocysteine S-methyltransferase 1; epididymis secretory sperm binding protein Li 61p

NCBI Summary for BHMT

This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008]

UniProt Comments for BHMT

BHMT: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - cysteine and methionine; Methyltransferase; EC 2.1.1.5

Chromosomal Location of Human Ortholog: 5q14.1

Cellular Component: protein complex; cytoplasm; cytosol

Molecular Function: betaine-homocysteine S-methyltransferase activity; homocysteine S-methyltransferase activity; zinc ion binding; protein complex binding

Biological Process: S-methylmethionine cycle; protein amino acid methylation; betaine catabolic process; sulfur amino acid metabolic process; S-adenosylmethionine metabolic process; response to organic nitrogen; betaine metabolic process; regulation of homocysteine metabolic process
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Research Articles on BHMT

1. Women harboring the single nucleotide polymorphism BHMT 742G>A have a decreased risk of a Down Syndrome pregnancy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BHMT antibody

 Reference Product  PubMed Publications
 CBS antibody  >38 publications with BHMT and CBS
 AHCY antibody  >7 publications with BHMT and AHCY
 MAT1A antibody  >6 publications with BHMT and MAT1A
 MAT2A antibody  >5 publications with BHMT and MAT2A
 MAT2B antibody  >4 publications with BHMT and MAT2B
 CTH antibody  >2 publications with BHMT and CTH
 AHCYL1 antibody  >1 publications with BHMT and AHCYL1
 DMGDH antibody  >1 publications with BHMT and DMGDH

Pathways associated with anti-BHMT antibody

 Products by Pathway  Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 Sulfur Amino Acid Metabolism Pathway antibodies  Sulfur Amino Acid Metabolism Pathway Diagram
 Trans-sulfuration And One Carbon Metabolism Pathway antibodies  Trans-sulfuration And One Carbon Metabolism Pathway Diagram

Diseases associated with anti-BHMT antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >31 publications with BHMT and Liver Diseases
 Cardiovascular Diseases Antibodies  >22 publications with BHMT and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >16 publications with BHMT and Nervous System Diseases
 Fatty Liver Antibodies  >14 publications with BHMT and Fatty Liver
 Liver Neoplasms Antibodies  >11 publications with BHMT and Liver Neoplasms
 Disease Models, Animal Antibodies  >10 publications with BHMT and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >10 publications with BHMT and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >8 publications with BHMT and Heart Diseases
 Kidney Diseases Antibodies  >7 publications with BHMT and Kidney Diseases
 Drug-Induced Liver Injury Antibodies  >7 publications with BHMT and Drug-Induced Liver Injury

Organs/Tissues associated with anti-BHMT antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >120 publications with BHMT and Liver
 Kidney Antibodies  >27 publications with BHMT and Kidney
 Brain Antibodies  >8 publications with BHMT and Brain
 Intestine Antibodies  >3 publications with BHMT and Intestine
 Eye Antibodies  >3 publications with BHMT and Eye
 Embryonic Tissue Antibodies  >2 publications with BHMT and Embryonic Tissue
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