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FOXC1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242402

Forkhead box C1 (FOXC1) belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of FOXC1 has not yet been determined; however, it has been shown to play a role in the… More details

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Product Overview

Product Name
FOXC1, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human FOXC1
Product Gene Name
anti-FOXC1 antibody
Product Synonym Names
Anti-FOXC1 Antibody (C-Terminus) IHC-plus; FOXC1; Forkhead-like 7; FREAC3; FKHL7; Forkhead-related activator 3; Forkhead-related protein FKHL7; IGDA; IHG1; IRID1; Forkhead box protein C1; Mesenchyme fork head protein 1; Myeloid factor-delta; ARA; Forkhead box C1; FREAC-3; RIEG3; Human FOXC1
Clonality
Polyclonal
Host
Goat
Species Reactivity
Xenopus, Gorilla, Human, Monkey, Mouse, Zebrafish
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human FOXC1.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
56,789 Da
OMIM
phenotype 604229
3D Structure
ModBase 3D Structure for Q12948
Target Species
Human
Immunogen Description
Synthetic peptide RTSGAFVYDCSKF from the C-terminus of human FOXC1 (NP_001444.2). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Mouse, Elephant, Opossum, Xenopus, Stickleback, Pufferfish, Zebrafish (100%); Salmon (92%).
Immunogen Type
Synthetic peptide
Immunogen
FOXC1 antibody was raised against synthetic peptide RTSGAFVYDCSKF from the C-terminus of human FOXC1 (NP_001444.2). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Mouse, Elephant, Opossum, Xenopus, Stickleback, Pufferfish, Zebrafish (100%); Salmon (92%).
Antigen Modification
C-Terminus

Product Categories/Family for anti-FOXC1 antibody

Family: Transcription factor
Applications Tested/Suitable for anti-FOXC1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-FOXC1 antibody
ELISA (1:32000), IHC-P (3.75 ug/ml), WB (0.5 - 1.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-FOXC1 antibody

Anti-FOXC1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
Goat Anti-FOXC1 Polyclonal Antibody – Cat# MBS242402

Immunohistochemistry (IHC) of anti-FOXC1 antibody

Anti-FOXC1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
Goat Anti-FOXC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242402

Western Blot (WB) of anti-FOXC1 antibody

Antibody staining (0.5 ug/ml) of Human Bone Marrow lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
Goat Anti-FOXC1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS242402

Other Notes

Small volumes of anti-FOXC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOXC1 purchase

MBS242402 is an antibody targeting FOXC1. Also known as Goat Polyclonal to Human FOXC1. Reactive in Xenopus, Gorilla, Human, Monkey, Mouse, Zebrafish. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for FOXC1. It may not necessarily be applicable to this product.

NCBI GI #
119395716
NCBI GeneID
2296
NCBI Accession #
NP_001444.2
UniProt Primary Accession #
Q12948
UniProt Secondary Accession #
Q86UP7; Q9BYM1; Q9NUE5; Q9UDD0; Q9UP06
UniProt Related Accession #
Q12948
GenBank Nucleotide #
NM_001453.2
NCBI Official Full Name
forkhead box protein C1
NCBI Official Synonym Full Names
forkhead box C1
NCBI Official Symbol
FOXC1
NCBI Official Synonym Symbols
ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3
UniProt Protein Name
Forkhead box protein C1
UniProt Synonym Protein Names
Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3
Protein Family
Forkhead box protein
UniProt Gene Name
FOXC1
UniProt Synonym Gene Names
FKHL7; FREAC3; FREAC-3
UniProt Entry Name
FOXC1_HUMAN
NCBI Protein Information
forkhead box protein C1; myeloid factor-delta; forkhead box C1 protein; forkhead-related activator 3; forkhead-related protein FKHL7; forkhead, drosophila, homolog-like 7; forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7

NCBI Summary for FOXC1

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]
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UniProt Comments for FOXC1

FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined.

Protein type: Transcription factor; DNA-binding; Cell development/differentiation; Cell cycle regulation

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: nucleoplasm; cytoplasm; nuclear heterochromatin; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; sequence-specific DNA binding; DNA bending activity; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; collagen fibril organization; glycosaminoglycan metabolic process; neural crest cell development; paraxial mesoderm formation; positive regulation of transcription, DNA-dependent; heart development; cardiac muscle cell proliferation; ovarian follicle development; regulation of transcription, DNA-dependent; ureteric bud development; germ cell migration; ventricular cardiac muscle morphogenesis; negative regulation of mitotic cell cycle; lacrimal gland development; regulation of blood vessel size; skeletal development; mesenchymal cell development; Notch signaling pathway; somitogenesis; cell migration; ossification; camera-type eye development; in utero embryonic development; regulation of organ growth; odontogenesis of dentine-containing teeth; cell proliferation; eye development; embryonic heart tube development; artery morphogenesis; blood vessel remodeling; positive regulation of transcription from RNA polymerase II promoter; brain development; lymph vessel development; vascular endothelial growth factor receptor signaling pathway

Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1
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Research Articles on FOXC1

1. suggest that reduced expression of miR-639 underscores the mechanism of TGFbeta-induced epithelial-mesenchymal transition in tongue squamous cell carcinoma by targeting FOXC1 and may serve as therapeutic targets in the process of metastasis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FOXC1 antibody

 Reference Product  PubMed Publications
 PITX2 antibody  >66 publications with FOXC1 and PITX2
 CYP1B1 antibody  >20 publications with FOXC1 and CYP1B1
 MMP7 antibody  >3 publications with FOXC1 and MMP7
 MESP1 antibody  >1 publications with FOXC1 and MESP1
 TCF15 antibody  >1 publications with FOXC1 and TCF15

Diseases associated with anti-FOXC1 antibody

 Disease Name  Pubmed Publications
 AXENFELD-RIEGER SYNDROME, TYPE 3 Antibodies  >48 publications with FOXC1 and AXENFELD-RIEGER SYNDROME, TYPE 3
 AXENFELD-RIEGER SYNDROME, TYPE 1 Antibodies  >48 publications with FOXC1 and AXENFELD-RIEGER SYNDROME, TYPE 1
 Chromosome Aberrations Antibodies  >29 publications with FOXC1 and Chromosome Aberrations
 Breast Neoplasms Antibodies  >22 publications with FOXC1 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >14 publications with FOXC1 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >8 publications with FOXC1 and Adenocarcinoma
 Hyperplasia Antibodies  >6 publications with FOXC1 and Hyperplasia
 Heart Failure Antibodies  >4 publications with FOXC1 and Heart Failure
 Dandy-Walker Syndrome Antibodies  >4 publications with FOXC1 and Dandy-Walker Syndrome
 Atrophy Antibodies  >3 publications with FOXC1 and Atrophy

Organs/Tissues associated with anti-FOXC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >145 publications with FOXC1 and Eye
 Embryonic Tissue Antibodies  >30 publications with FOXC1 and Embryonic Tissue
 Bone Antibodies  >26 publications with FOXC1 and Bone
 Heart Antibodies  >20 publications with FOXC1 and Heart
 Vascular Antibodies  >18 publications with FOXC1 and Vascular
 Brain Antibodies  >18 publications with FOXC1 and Brain
 Kidney Antibodies  >13 publications with FOXC1 and Kidney
 Nerve Antibodies  >12 publications with FOXC1 and Nerve
 Connective Tissue Antibodies  >6 publications with FOXC1 and Connective Tissue
 Lung Antibodies  >5 publications with FOXC1 and Lung
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