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CORO1A Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242433

MBS242433 is an antibody targeting CORO1A. Also known as Goat Polyclonal to Human CORO1A / p57. Reactive in Gibbon, Bovine, Dog, Gorilla, Horse, Human, MonkeyPredicted Reactivity: Mouse, Rat, Bat, Hamster (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Overview

Product Name
CORO1A / p57, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human CORO1A / p57
Product Gene Name
anti-CORO1A antibody
Product Synonym Gene Name
p57
Product Synonym Names
Anti-CORO1A / p57 Antibody (C-Terminus) IHC-plus; CORO1A; Clipin-A; Coronin-like protein A; Coronin-like protein p57; CLIPINA; Coronin-1; Coronin-1A; HCORO1; p57; TACO; CLABP; CORO1; Human CORO1A; p57
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey
Predicted Reactivity: Mouse, Rat, Bat, Hamster (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human CORO1A.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
51,026 Da
OMIM
gene 615401
3D Structure
ModBase 3D Structure for P31146
Target Species
Human
Immunogen Description
Synthetic peptide C-KRLDRLEETVQAK from the C-terminus of human CORO1A (NP_009005.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bovine, Horse (100%); Mouse, Rat, Hamster, Bat (92%); Rabbit (85%).
Immunogen Type
Synthetic peptide
Immunogen
CORO1A / p57 antibody was raised against synthetic peptide C-KRLDRLEETVQAK from the C-terminus of human CORO1A (NP_009005.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bovine, Horse (100%); Mouse, Rat, Hamster, Bat (92%); Rabbit (85%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-CORO1A antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CORO1A antibody
ELISA (1:16000), IHC-P (3.75 ug/ml), WB (1:16000, 0.25 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-CORO1A antibody

Anti-CORO1A antibody IHC of human small intestine, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
Goat Anti-CORO1A Polyclonal Antibody – Cat# MBS242433

Immunohistochemistry (IHC) of anti-CORO1A antibody

Anti-CORO1A antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
Goat Anti-CORO1A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242433

Western Blot (WB) of anti-CORO1A antibody

Antibody staining (0.3 ug/ml) of Jurkat lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
Goat Anti-CORO1A Polyclonal Antibody, Western Blot (WB) – Cat# MBS242433

Other Notes

Small volumes of anti-CORO1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CORO1A. It may not necessarily be applicable to this product.

NCBI GI #
5902134
NCBI GeneID
11151
NCBI Accession #
NP_009005.1
UniProt Primary Accession #
P31146
UniProt Secondary Accession #
Q2YD73; B2RBL1
UniProt Related Accession #
P31146
GenBank Nucleotide #
NM_007074.3
NCBI Official Full Name
coronin-1A
NCBI Official Synonym Full Names
coronin, actin binding protein, 1A
NCBI Official Symbol
CORO1A
NCBI Official Synonym Symbols
p57; IMD8; TACO; CLABP; HCORO1; CLIPINA
UniProt Protein Name
Coronin-1A
UniProt Synonym Protein Names
Coronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACO
Protein Family
Coronin
UniProt Gene Name
CORO1A
UniProt Synonym Gene Names
CORO1; Clipin-A; TACO
UniProt Entry Name
COR1A_HUMAN
NCBI Protein Information
coronin-1A; clipin-A; coronin-like protein A; coronin-like protein p57; tryptophan aspartate-containing coat protein

NCBI Summary for CORO1A

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
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UniProt Comments for CORO1A

coronin 1A: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. Belongs to the WD repeat coronin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cortical actin cytoskeleton; protein complex; early endosome; immunological synapse; actin filament; phagocytic vesicle; intercellular junction; phagocytic vesicle membrane; membrane; axon; lamellipodium; cytoplasm; plasma membrane; nucleus; phagocytic cup

Molecular Function: protein C-terminus binding; actin filament binding; protein binding; protein homodimerization activity; cytoskeletal protein binding; phosphoinositide 3-kinase binding

Biological Process: negative regulation of vesicle fusion; leukocyte chemotaxis; actin filament organization; cell-substrate adhesion; regulation of release of sequestered calcium ion into cytosol; phagocytosis; uropod organization and biogenesis; phagolysosome formation; regulation of cell shape; regulation of actin filament polymerization; positive chemotaxis; homeostasis of number of cells within a tissue; calcium ion transport; negative regulation of actin nucleation; innate immune response; positive regulation of T cell proliferation; T cell homeostasis; negative regulation of neuron apoptosis; cell motility; actin cytoskeleton organization and biogenesis; positive regulation of cell migration

Disease: Immunodeficiency 8
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Research Articles on CORO1A

1. Absence of coronin 1A is associated with severe combined immunodeficiency in humans, hypomorphic mutations lead to a profound defect in naive T cells, expansion of oligoclonal memory T cells, and susceptibility to Epstein Barr B lymphoproliferation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CORO1A antibody

 Products by Pathway  Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram

Diseases associated with anti-CORO1A antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with CORO1A and Disease Models, Animal
 Kidney Diseases Antibodies  >2 publications with CORO1A and Kidney Diseases
 Breast Neoplasms Antibodies  >1 publications with CORO1A and Breast Neoplasms
 Fibrosis Antibodies  >1 publications with CORO1A and Fibrosis
 Tuberculosis Antibodies  >1 publications with CORO1A and Tuberculosis
 Mammary Neoplasms, Animal Antibodies  >1 publications with CORO1A and Mammary Neoplasms, Animal
 Carcinoma Antibodies  >1 publications with CORO1A and Carcinoma

Organs/Tissues associated with anti-CORO1A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with CORO1A and Blood
 Bone Antibodies  >3 publications with CORO1A and Bone
 Bone Marrow Antibodies  >3 publications with CORO1A and Bone Marrow
 Brain Antibodies  >3 publications with CORO1A and Brain
 Embryonic Tissue Antibodies  >2 publications with CORO1A and Embryonic Tissue
 Kidney Antibodies  >2 publications with CORO1A and Kidney
 Thymus Antibodies  >2 publications with CORO1A and Thymus
 Mammary Gland Antibodies  >1 publications with CORO1A and Mammary Gland
 Eye Antibodies  >1 publications with CORO1A and Eye
 Vascular Antibodies  >1 publications with CORO1A and Vascular
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