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RANGAP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242446

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1… More details

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Product Overview

Product Name
RANGAP1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Xenopus RANGAP1
Product Gene Name
anti-RANGAP1 antibody
Product Synonym Names
Anti-RANGAP1 Antibody IHC-plus; RANGAP1; Fug1; KIAA1835; SD; Segregation distortion; Segregation distorter homolog; Xenopus RANGAP1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Xenopus, Human
Predicted Reactivity: Gorilla, Orangutan, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit, Chicken, Zebrafish (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Unpurified serum
Specificity
Reacts with human & Xenopus RanGAP
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Molecular Weight
63,542 Da
OMIM
602362
3D Structure
ModBase 3D Structure for P46060
Target Species
Xenopus
Immunogen Description
A mixture of two peptides from Xenopus RanGAP, n-CHWSDMFTGRLRPEI-c & n-CPSPEKLVRMGPRRSA-.
Immunogen
RANGAP1 antibody was raised against a mixture of two peptides from Xenopus RanGAP, n-CHWSDMFTGRLRPEI-c & n-CPSPEKLVRMGPRRSA-. Percent identity by BLAST analysis: Xenopus (100%); Human, Gorilla, Orangutan, Gibbon, Monkey, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Horse, Rabbit, Opossum, Turkey, Chicken, Platypus, Lizard, Zebrafish (93%); Seabass, Salmon, Stickleback, Pufferfish (87%); Nematode (80%).
Applications Tested/Suitable for anti-RANGAP1 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-RANGAP1 antibody
IF, IHC-P (1:100), WB (1:500 - 1:1000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-RANGAP1 antibody

Anti-RANGAP1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Rabbit Anti-RANGAP1 Polyclonal Antibody – Cat# MBS242446

Immunohistochemistry (IHC) of anti-RANGAP1 antibody

Anti-RANGAP1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Rabbit Anti-RANGAP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242446

Other Notes

Small volumes of anti-RANGAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RANGAP1 purchase

MBS242446 is an antibody targeting RANGAP1. Also known as Rabbit Polyclonal to Xenopus RANGAP1. Reactive in Xenopus, Human
Predicted Reactivity: Gorilla, Orangutan, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit, Chicken, Zebrafish (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RANGAP1. It may not necessarily be applicable to this product.

NCBI GI #
4506411
NCBI GeneID
5905
NCBI Accession #
NP_002874.1
UniProt Primary Accession #
P46060
UniProt Secondary Accession #
Q96JJ2
UniProt Related Accession #
P46060
GenBank Nucleotide #
NM_002883.3
NCBI Official Full Name
ran GTPase-activating protein 1
NCBI Official Synonym Full Names
Ran GTPase activating protein 1
NCBI Official Symbol
RANGAP1
NCBI Official Synonym Symbols
SD; Fug1; RANGAP
UniProt Protein Name
Ran GTPase-activating protein 1
Protein Family
RAN GTPase-activating protein
UniProt Gene Name
RANGAP1
UniProt Synonym Gene Names
KIAA1835; SD; RanGAP1
UniProt Entry Name
RAGP1_HUMAN
NCBI Protein Information
ran GTPase-activating protein 1; segregation distortion; segregation distorter homolog

NCBI Summary for RANGAP1

This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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UniProt Comments for RANGAP1

RANGAP1: a cytoplasmic GTPase activator for the Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. Homodimerizes. Forms a tight complex in association with RANBP2 and the ubiquitin-conjugating enzyme E2 (UBC9).

Protein type: GAPs; GAPs, Ras

Chromosomal Location of Human Ortholog: 22q13

Cellular Component: kinetochore; spindle pole; nuclear membrane; perinuclear region of cytoplasm; cytoplasm; nuclear pore; cytosol

Molecular Function: protein binding

Biological Process: negative regulation of protein export from nucleus; mitotic cell cycle; signal transduction
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Research Articles on RANGAP1

1. Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RANGAP1 antibody

 Reference Product  PubMed Publications
 SUMO1 antibody  >69 publications with RANGAP1 and SUMO1
 RANBP2 antibody  >45 publications with RANGAP1 and RANBP2
 RCC1 antibody  >26 publications with RANGAP1 and RCC1
 SUMO2 antibody  >16 publications with RANGAP1 and SUMO2
 SENP1 antibody  >5 publications with RANGAP1 and SENP1
 SENP2 antibody  >4 publications with RANGAP1 and SENP2

Pathways associated with anti-RANGAP1 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
 Interactions Of Rev With Host Cellular Proteins Pathway antibodies  Interactions Of Rev With Host Cellular Proteins Pathway Diagram
 Late Phase Of HIV Life Cycle Pathway antibodies  Late Phase Of HIV Life Cycle Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram

Diseases associated with anti-RANGAP1 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >5 publications with RANGAP1 and Immune System Diseases
 Necrosis Antibodies  >4 publications with RANGAP1 and Necrosis
 Nervous System Diseases Antibodies  >3 publications with RANGAP1 and Nervous System Diseases
 Weight Loss Antibodies  >1 publications with RANGAP1 and Weight Loss
 Lung Neoplasms Antibodies  >1 publications with RANGAP1 and Lung Neoplasms
 Heart Failure Antibodies  >1 publications with RANGAP1 and Heart Failure
 Cell Transformation, Neoplastic Antibodies  >1 publications with RANGAP1 and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >1 publications with RANGAP1 and Heart Diseases
 Inflammation Antibodies  >1 publications with RANGAP1 and Inflammation
 Hyperplasia Antibodies  >1 publications with RANGAP1 and Hyperplasia

Organs/Tissues associated with anti-RANGAP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with RANGAP1 and Blood
 Brain Antibodies  >5 publications with RANGAP1 and Brain
 Muscle Antibodies  >4 publications with RANGAP1 and Muscle
 Kidney Antibodies  >3 publications with RANGAP1 and Kidney
 Vascular Antibodies  >3 publications with RANGAP1 and Vascular
 Liver Antibodies  >2 publications with RANGAP1 and Liver
 Prostate Antibodies  >2 publications with RANGAP1 and Prostate
 Placenta Antibodies  >2 publications with RANGAP1 and Placenta
 Embryonic Tissue Antibodies  >2 publications with RANGAP1 and Embryonic Tissue
 Testis Antibodies  >2 publications with RANGAP1 and Testis
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