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TOCA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242480

MBS242480 is an antibody targeting TOCA1. Also known as Rabbit Polyclonal to Human TOCA1 / FNBP1L. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Overview

Product Name
TOCA1 / FNBP1L, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human TOCA1 / FNBP1L
Product Gene Name
anti-TOCA1 antibody
Product Synonym Gene Name
FNBP1L
Product Synonym Names
Anti-TOCA1 / FNBP1L Antibody (C-Terminus) IHC-plus; FNBP1L; C1orf39; Formin-binding protein 1-like; Formin binding protein 1-like; TOCA1; Toca-1; Human TOCA1; FNBP1L
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
69,894 Da
OMIM
608848
3D Structure
ModBase 3D Structure for Q5T0N5
Target Species
Human
Immunogen Description
17 amino acid peptide near the carboxy terminus of the human TOCA-1.
Immunogen
TOCA1 / FNBP1L antibody was raised against 17 amino acid peptide near the carboxy terminus of the human TOCA-1.
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-TOCA1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-TOCA1 antibody
ELISA, IHC-P (2.5 ug/ml), WB (1 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-TOCA1 antibody

Anti-FNBP1L / Toca-1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-TOCA1 Polyclonal Antibody – Cat# MBS242480

Immunohistochemistry (IHC) of anti-TOCA1 antibody

Anti-FNBP1L / Toca-1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-TOCA1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242480

Immunofluorescence (IF) of anti-TOCA1 antibody

Immunofluorescence of TOCA-1 in Human Brain cells with TOCA-1 antibody at 20 ug/ml.
Rabbit Anti-TOCA1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS242480

Western Blot (WB) of anti-TOCA1 antibody

Western blot of TOCA-1 in mouse brain tissue lysate with in (A) the absence and (B) the presence of blocking peptide with TOCA-1 antibody at 1 ug/ml. Below: Immunohistochemistry of TOCA-1 in human brain tissue with TOCA-1 antibody at 2.5 ug/ml.
Rabbit Anti-TOCA1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS242480

Other Notes

Small volumes of anti-TOCA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TOCA1. It may not necessarily be applicable to this product.

NCBI GI #
41581463
NCBI GeneID
54874
NCBI Accession #
NP_060207.2
UniProt Primary Accession #
Q5T0N5
UniProt Secondary Accession #
Q5T0N6; Q6B097; Q6P653; Q6R4Q4; Q9NXG1; J3QSS4
UniProt Related Accession #
Q5T0N5
GenBank Nucleotide #
NM_017737.4
NCBI Official Full Name
formin-binding protein 1-like isoform 2
NCBI Official Synonym Full Names
formin binding protein 1-like
NCBI Official Symbol
FNBP1L
NCBI Official Synonym Symbols
TOCA1; C1orf39
UniProt Protein Name
Formin-binding protein 1-like
UniProt Synonym Protein Names
Transducer of Cdc42-dependent actin assembly protein 1; Toca-1
UniProt Gene Name
FNBP1L
UniProt Synonym Gene Names
C1orf39; TOCA1; Toca-1
UniProt Entry Name
FBP1L_HUMAN
NCBI Protein Information
formin-binding protein 1-like; toca-1; transducer of Cdc42-dependent actin assembly 1; transducer of Cdc42-dependent actin assembly protein 1

NCBI Summary for TOCA1

The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for TOCA1

FNBP1L: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. Belongs to the FNBP1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1p22.1

Cellular Component: cytoskeleton; cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; cell cortex

Molecular Function: protein binding; lipid binding

Biological Process: positive regulation of filopodium formation; vesicle transport along actin filament; vesicle organization and biogenesis; membrane invagination; cilium biogenesis; autophagy; membrane budding
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Research Articles on TOCA1

1. GWAS results show that the aggregate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the three largest cohorts; FNBP1L was also significantly associated with childhood intelligence

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TOCA1 antibody

 Reference Product  PubMed Publications
 CDC42 antibody  >14 publications with TOCA1 and CDC42
 WASL antibody  >4 publications with TOCA1 and WASL
 ATG3 antibody  >1 publications with TOCA1 and ATG3

Diseases associated with anti-TOCA1 antibody

 Disease Name  Pubmed Publications
 Neoplasm Invasiveness Antibodies  >3 publications with TOCA1 and Neoplasm Invasiveness
 Blood Coagulation Disorders Antibodies  >2 publications with TOCA1 and Blood Coagulation Disorders
 Neoplasm Metastasis Antibodies  >2 publications with TOCA1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >2 publications with TOCA1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with TOCA1 and Neoplasms, Experimental
 Edema Antibodies  >1 publications with TOCA1 and Edema
 Skin Neoplasms Antibodies  >1 publications with TOCA1 and Skin Neoplasms
 Adenocarcinoma Antibodies  >1 publications with TOCA1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >1 publications with TOCA1 and Lung Neoplasms

Organs/Tissues associated with anti-TOCA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >4 publications with TOCA1 and Nerve
 Brain Antibodies  >3 publications with TOCA1 and Brain
 Lung Antibodies  >1 publications with TOCA1 and Lung
 Blood Antibodies  >1 publications with TOCA1 and Blood
 Skin Antibodies  >1 publications with TOCA1 and Skin
 Muscle Antibodies  >1 publications with TOCA1 and Muscle
 Eye Antibodies  >1 publications with TOCA1 and Eye
 Embryonic Tissue Antibodies  >1 publications with TOCA1 and Embryonic Tissue
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