GPAM Antibody – Rabbit Polyclonal

This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

GPAM: glycerol-3-phosphate acyltransferase is an integral multi-pass enzyme of the mitochondrial outer membrane. It performs the first step in de novo phospholipid biosynthesis. Member of the phospholipid and glycerol acyltransferase family

Protein type: Lipid Metabolism - glycerolipid; EC 2.3.1.15; Lipid Metabolism - glycerophospholipid; Membrane protein, multi-pass; Membrane protein, integral; Transferase; Mitochondrial

Chromosomal Location of Human Ortholog: 10q25.2

Cellular Component: mitochondrial outer membrane; mitochondrial inner membrane; plasma membrane; integral to membrane

Molecular Function: glycerol-3-phosphate O-acyltransferase activity

Biological Process: regulation of cytokine secretion; acyl-CoA metabolic process; glycerophospholipid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; positive regulation of multicellular organism growth; positive regulation of activated T cell proliferation; fatty acid metabolic process; phospholipid metabolic process; fatty acid homeostasis; response to glucose stimulus; phosphatidic acid biosynthetic process; CDP-diacylglycerol biosynthetic process; defense response to virus; phospholipid homeostasis