Goat Anti-PLA2G16 Polyclonal Antibody – Cat# MBS242532

Anti-PLA2G16 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

PLA2G16 Antibody – Goat Polyclonal

Name: PLA2G16 Antibody; Polyclonal; Goat; Human/Rabbit/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS242532
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242532

MBS242532 is an antibody targeting PLA2G16. Also known as Goat Polyclonal to Human PLA2G16 / HRASLS3. Reactive in Gibbon, Gorilla, Human, Monkey, Orangutan, RabbitPredicted Reactivity: Mouse (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PLA2G16 / HRASLS3, Polyclonal Antibody

Full Product Name

Goat Polyclonal to Human PLA2G16 / HRASLS3

Product Gene Name

anti-PLA2G16 antibody

Product Synonym Gene Name

HRASLS3

Product Synonym Names

Anti-PLA2G16 / HRASLS3 Antibody (N-Terminus) IHC-plus; PLA2G16; AdPLA; Adipose-specific PLA2; Group XVI phospholipase A1/A2; Group XVI phospholipase A2; H-REV107-1; HRAS-like suppressor 3; HRASLS3; HREV107-3; HRAS-like suppressor 1; HREV107-1; H-rev 107 protein homolog; HREV107; HRSL3; Phospholipase A2; Human PLA2G16; HRASLS3

Clonality

Polyclonal

Host

Goat

Species Reactivity

Gibbon, Gorilla, Human, Monkey, Orangutan, Rabbit
Predicted Reactivity: Mouse (at least 90% immunogen sequence identity)

Form/Format

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

Purity/Purification

Immunoaffinity Purified

Concentration

0.5 mg/ml (lot specific)

Specificity

Human PLA2G16. Reported variants represent identical protein:NP_009000.2 and NP_001121675.1).

Preparation and Storage

Store at -20 degree C. Minimize freezing and thawing.

Molecular Weight

17,937 Da

OMIM

613867

3D Structure

ModBase 3D Structure for P53816

Target Species

Human

Immunogen Description

Synthetic peptide RAPIPEPKPGDLIE-C from the N-terminus of human PLA2G16 (NP_009000.2). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Marmoset, Rabbit (100%); Mouse (93%); Monkey, Rat, Bovine (86%).

Immunogen Type

Synthetic peptide

Immunogen

PLA2G16 / HRASLS3 antibody was raised against synthetic peptide RAPIPEPKPGDLIE-C from the N-terminus of human PLA2G16 (NP_009000.2). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Marmoset, Rabbit (100%); Mouse (93%); Monkey, Rat, Bovine (86%).

Antigen Modification

N-Terminus

Applications Tested/Suitable for anti-PLA2G16 antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-PLA2G16 antibody

ELISA (1:128000), IHC-P (5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Other Notes

Small volumes of anti-PLA2G16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PLA2G16. It may not necessarily be applicable to this product.

NCBI GI #

189571618

NCBI GeneID

11145

NCBI Accession #

NP_009000.2

UniProt Primary Accession #

P53816

UniProt Secondary Accession #

Q3SYI3; Q9HDD1; B2R7Q4; B7XAK5

UniProt Related Accession #

P53816

GenBank Nucleotide #

NM_007069.3

NCBI Official Full Name

HRAS-like suppressor 3

NCBI Official Synonym Full Names

phospholipase A2, group XVI

NCBI Official Symbol

PLA2G16

NCBI Official Synonym Symbols

AdPLA; HRSL3; HRASLS3; HREV107; HREV107-1; HREV107-3; H-REV107-1

UniProt Protein Name

HRAS-like suppressor 3

UniProt Synonym Protein Names

Adipose-specific phospholipase A2; AdPLA; Group XVI phospholipase A1/A2; H-rev 107 protein homolog; HRAS-like suppressor 1; HREV107-1; HREV107-3; Renal carcinoma antigen NY-REN-65

Protein Family

HRAS-like suppressor

UniProt Gene Name

PLA2G16

UniProt Synonym Gene Names

HRASLS3; HREV107; HRSL3; AdPLA

UniProt Entry Name

HRSL3_HUMAN

NCBI Protein Information

HRAS-like suppressor 3; adipose-specific PLA2; HRAS-like suppressor 1; H-rev 107 protein homolog; group XVI phospholipase A2; group XVI phospholipase A1/A2; Ca-independent phospholipase A1/2; adipose-specific phospholipase A2; renal carcinoma antigen NY-REN-65

UniProt Comments for PLA2G16

PLA2G16: Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue. N- and O- acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity. Belongs to the H-rev107 family.

Protein type: EC 3.1.1.4; Membrane protein, integral; EC 3.1.1.32

Chromosomal Location of Human Ortholog: 11q12.3

Cellular Component: perinuclear region of cytoplasm; endoplasmic reticulum; integral to membrane; cytosol

Molecular Function: phospholipase A2 activity; protein binding; phospholipase A1 activity

Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; lipid catabolic process; negative regulation of cell cycle

Research Articles on PLA2G16

1. several mutant p53 proteins bind the Pla2g16 promoter at E26 transformation-specific (ETS) binding motifs and knockdown of ETS2 suppressed mutant p53 induction of Pla2g16.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PLA2G16 antibody

Products by Pathway	Pathway Diagram
Acyl Chain Remodelling Of PC Pathway antibodies	Acyl Chain Remodelling Of PC Pathway Diagram
Acyl Chain Remodelling Of PE Pathway antibodies	Acyl Chain Remodelling Of PE Pathway Diagram
Acyl Chain Remodelling Of PI Pathway antibodies	Acyl Chain Remodelling Of PI Pathway Diagram
Acyl Chain Remodelling Of PS Pathway antibodies	Acyl Chain Remodelling Of PS Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Ether Lipid Metabolism Pathway antibodies	Ether Lipid Metabolism Pathway Diagram
Ether Lipid Metabolism Pathway antibodies	Ether Lipid Metabolism Pathway Diagram
Glycerophospholipid Biosynthesis Pathway antibodies	Glycerophospholipid Biosynthesis Pathway Diagram
Glycerophospholipid Metabolism Pathway antibodies	Glycerophospholipid Metabolism Pathway Diagram

Diseases associated with anti-PLA2G16 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>8 publications with PLA2G16 and Carcinoma
Insulin Resistance Antibodies	>2 publications with PLA2G16 and Insulin Resistance
Cell Transformation, Neoplastic Antibodies	>2 publications with PLA2G16 and Cell Transformation, Neoplastic
Neoplasms, Experimental Antibodies	>1 publications with PLA2G16 and Neoplasms, Experimental
Lung Neoplasms Antibodies	>1 publications with PLA2G16 and Lung Neoplasms
Weight Loss Antibodies	>1 publications with PLA2G16 and Weight Loss
Carcinoma, Hepatocellular Antibodies	>1 publications with PLA2G16 and Carcinoma, Hepatocellular
Breast Neoplasms Antibodies	>1 publications with PLA2G16 and Breast Neoplasms
Liver Neoplasms Antibodies	>1 publications with PLA2G16 and Liver Neoplasms
Liver Neoplasms, Experimental Antibodies	>1 publications with PLA2G16 and Liver Neoplasms, Experimental

Organs/Tissues associated with anti-PLA2G16 antibody

Organ/Tissue Name	Pubmed Publications
Adipose Tissue Antibodies	>5 publications with PLA2G16 and Adipose Tissue
Liver Antibodies	>3 publications with PLA2G16 and Liver
Lung Antibodies	>3 publications with PLA2G16 and Lung
Stomach Antibodies	>2 publications with PLA2G16 and Stomach
Kidney Antibodies	>2 publications with PLA2G16 and Kidney
Muscle Antibodies	>2 publications with PLA2G16 and Muscle
Testis Antibodies	>2 publications with PLA2G16 and Testis
Heart Antibodies	>1 publications with PLA2G16 and Heart
Embryonic Tissue Antibodies	>1 publications with PLA2G16 and Embryonic Tissue
Intestine Antibodies	>1 publications with PLA2G16 and Intestine