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MED28 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242802

MBS242802 is an antibody targeting MED28. Also known as Rabbit Polyclonal to Human MED28 / Magicin. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MED28 / Magicin, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human MED28 / Magicin
Product Gene Name
anti-MED28 antibody
Product Synonym Names
Anti-MED28 / Magicin Antibody (Internal) IHC-plus; MED28; EG1; Endothelial-derived protein 1; DKFZP434N185; Magicin; Mediator complex subunit 28; Tumor angiogenesis marker EG-1; Endothelial-derived gene 1; Human MED28; Magicin
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
19,520 Da
OMIM
610311
3D Structure
ModBase 3D Structure for Q9H204
Target Species
Human
Immunogen Description
A 17 amino acid peptide from near the center of human MED28.
Immunogen Type
Synthetic peptide
Immunogen
MED28 / Magicin antibody was raised against a 17 amino acid peptide from near the center of human MED28.
Antigen Modification
Internal
Applications Tested/Suitable for anti-MED28 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-MED28 antibody
IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)
Usage: MED28 antibody can be used for detection of MED28 by Western blot at 0.5-1 ug/ml

Immunohistochemistry (IHC) of anti-MED28 antibody

Anti-MED28 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-MED28 Polyclonal Antibody – Cat# MBS242802

Western Blot (WB) of anti-MED28 antibody

Western blot of MED28 in human brain tissue lysate with MED28 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-MED28 Polyclonal Antibody, Western Blot (WB) – Cat# MBS242802

Other Notes

Small volumes of anti-MED28 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MED28. It may not necessarily be applicable to this product.

NCBI GI #
52851391
NCBI GeneID
80306
NCBI Accession #
NP_079481.2
UniProt Primary Accession #
Q9H204
UniProt Secondary Accession #
Q9BZJ5
UniProt Related Accession #
Q9H204
GenBank Nucleotide #
NM_025205.4
NCBI Official Full Name
mediator of RNA polymerase II transcription subunit 28
NCBI Official Synonym Full Names
mediator complex subunit 28
NCBI Official Symbol
MED28
NCBI Official Synonym Symbols
EG1; magicin; 1500003D12Rik
UniProt Protein Name
Mediator of RNA polymerase II transcription subunit 28
UniProt Synonym Protein Names
Endothelial-derived protein 1; Mediator complex subunit 28; Merlin and Grb2-interacting cytoskeletal protein; Magicin; Tumor angiogenesis marker EG-1
Protein Family
Mediator of RNA polymerase II transcription
UniProt Gene Name
MED28
UniProt Synonym Gene Names
EG1; Magicin
UniProt Entry Name
MED28_HUMAN
NCBI Protein Information
mediator of RNA polymerase II transcription subunit 28; endothelial-derived gene 1; endothelial-derived protein 1; tumor angiogenesis marker EG-1; merlin and Grb2-interacting cytoskeletal protein; mediator of RNA polymerase II transcription, subunit 28 homolog

UniProt Comments for MED28

MED28: a component of the mediator complex that can either repress or activate transcription. Mediator complexes are essential for basal and regulated expression of nearly all RNA polymerase II-dependent genes. They may act as a bridge, conveying regulatory information from enhancers and other control elements to the promoter. May be part of a complex containing NF2/Merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. Up-regulated by endothelial cells when exposed to tumor conditioned media.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 4p16

Cellular Component: cortical actin cytoskeleton; membrane; Srb-mediator complex

Molecular Function: protein binding; actin binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; stem cell maintenance; negative regulation of smooth muscle cell differentiation
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Research Articles on MED28

1. This paper describes a link between Med23 and IFN-lambda3, provides evidence for the crucial role of IFN-lambda in HSV-1 immune control.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MED28 antibody

 Reference Product  PubMed Publications
 GRB2 antibody  >4 publications with MED28 and GRB2
 SRC antibody  >3 publications with MED28 and SRC
 MED26 antibody  >2 publications with MED28 and MED26
 MED27 antibody  >1 publications with MED28 and MED27
 MED17 antibody  >1 publications with MED28 and MED17
 MED21 antibody  >1 publications with MED28 and MED21
 MED30 antibody  >1 publications with MED28 and MED30
 LCK antibody  >1 publications with MED28 and LCK
 FYN antibody  >1 publications with MED28 and FYN

Diseases associated with anti-MED28 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >7 publications with MED28 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with MED28 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >1 publications with MED28 and Adenocarcinoma
 Mammary Neoplasms, Animal Antibodies  >1 publications with MED28 and Mammary Neoplasms, Animal
 Neoplasm Invasiveness Antibodies  >1 publications with MED28 and Neoplasm Invasiveness
 Inflammation Antibodies  >1 publications with MED28 and Inflammation
 Neoplasm Metastasis Antibodies  >1 publications with MED28 and Neoplasm Metastasis

Organs/Tissues associated with anti-MED28 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >4 publications with MED28 and Prostate
 Muscle Antibodies  >2 publications with MED28 and Muscle
 Vascular Antibodies  >1 publications with MED28 and Vascular
 Heart Antibodies  >1 publications with MED28 and Heart
 Intestine Antibodies  >1 publications with MED28 and Intestine
 Testis Antibodies  >1 publications with MED28 and Testis
 Liver Antibodies  >1 publications with MED28 and Liver
 Placenta Antibodies  >1 publications with MED28 and Placenta
 Umbilical Cord Antibodies  >1 publications with MED28 and Umbilical Cord
 Blood Antibodies  >1 publications with MED28 and Blood
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