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VPS37C Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242805

VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
VPS37C, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human VPS37C
Product Gene Name
Product Synonym Names
Anti-VPS37C Antibody (Internal) IHC-plus; VPS37C; HVps37C; PML39; Vacuolar protein sorting 37C; ESCRT-I complex subunit VPS37C; Human VPS37C
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Gorilla, Human, Orangutan
Predicted Reactivity: Monkey, Bat, Rabbit (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human VPS37C.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
38,659 Da
OMIM
610038
3D Structure
ModBase 3D Structure for A5D8V6
Target Species
Human
Immunogen Description
Synthetic peptide C-ETLKDKTLQELEELQ from an internal region of human VPS37C (NP_060436.4). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Marmoset (100%); Monkey, Bat, Rabbit (93%); Mouse, Rat, Hamster, Bovine, Dog, Horse (87%).
Immunogen Type
Synthetic peptide
Immunogen
VPS37C antibody was raised against synthetic peptide C-ETLKDKTLQELEELQ from an internal region of human VPS37C (NP_060436.4). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Marmoset (100%); Monkey, Bat, Rabbit (93%); Mouse, Rat, Hamster, Bovine, Dog, Horse (87%); Elephant (80%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-VPS37C antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-VPS37C antibody
ELISA (1:32000), IHC-P (3.75 ug/ml), WB (1:32000, 0.1 ug/ml)

Immunohistochemistry (IHC) of anti-VPS37C antibody

Anti-VPS37C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-VPS37C Polyclonal Antibody – Cat# MBS242805

Immunohistochemistry (IHC) of anti-VPS37C antibody

Anti-VPS37C antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-VPS37C Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242805

Western Blot (WB) of anti-VPS37C antibody

Antibody (0.03g/ml) staining of human duodenum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-VPS37C Polyclonal Antibody, Western Blot (WB) – Cat# MBS242805

Other Notes

Small volumes of anti-VPS37C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VPS37C purchase

MBS242805 is an antibody targeting VPS37C. Also known as Goat Polyclonal to Human VPS37C. Reactive in Gibbon, Gorilla, Human, Orangutan
Predicted Reactivity: Monkey, Bat, Rabbit (at least 90% immunogen sequence identity). Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for VPS37C. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
vacuolar protein sorting-associated protein 37C
NCBI Official Synonym Full Names
vacuolar protein sorting 37 homolog C (S. cerevisiae)
NCBI Official Symbol
VPS37C
UniProt Protein Name
Vacuolar protein sorting-associated protein 37C
UniProt Synonym Protein Names
ESCRT-I complex subunit VPS37C
UniProt Gene Name
VPS37C
UniProt Synonym Gene Names
PML39; hVps37C
UniProt Entry Name
VP37C_HUMAN
NCBI Protein Information
vacuolar protein sorting-associated protein 37C; hVps37C; vacuolar protein sorting 37C; ESCRT-I complex subunit VPS37C

NCBI Summary for VPS37C

VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]
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UniProt Comments for VPS37C

VPS37C: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Belongs to the VPS37 family.

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: late endosome membrane; endosome membrane

Molecular Function: protein binding; calcium-dependent protein binding

Biological Process: protein transport; viral reproduction; viral protein processing; viral infectious cycle; virus assembly; endosome transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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