Rabbit Anti-PTGDR Polyclonal Antibody – Cat# MBS242851

Anti-Prostaglandin D2 Receptor antibody IHC of human small intestine, villi. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PTGDR Antibody – Rabbit Polyclonal

Name: PTGDR Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS242851
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242851

The prostaglandin D2 receptor is a Prostanoid Receptor that binds prostaglandin D2. Studies suggest that this receptor may be involved in vision, mucous secretion, myometrial relaxation, and asthmatic response. More details

$630 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PTGDR / DP, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human PTGDR / DP

Product Gene Name

anti-PTGDR antibody

Product Synonym Gene Name

Product Synonym Names

Anti-PTGDR / DP Antibody (Cytoplasmic Domain) IHC-plus; PTGDR; DP; Dp receptor; PGD receptor; Prostaglandin D2 receptor (DP); Prostanoid DP receptor; PTGDR1; PGD2 receptor; Prostaglandin DP receptor; AS1; ASRT1; Dp prostanoid receptor; DP1; Prostaglandin D2 receptor; Human PTGDR; DP

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human
Predicted Reactivity: Gorilla, Monkey (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human Prostaglandin D2 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

32,354 Da

OMIM

gene 607277

3D Structure

ModBase 3D Structure for Q13258

Target Species

Human

Immunogen Description

Synthetic 19 amino acid peptide from 3rd cytoplasmic domain of human Prostaglandin D2 Receptor. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Monkey (95%); Gibbon (89%).

Immunogen Type

Synthetic peptide

Immunogen

PTGDR / DP antibody was raised against synthetic 19 amino acid peptide from 3rd cytoplasmic domain of human Prostaglandin D2 Receptor. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Monkey (95%); Gibbon (89%).

Antigen Modification

Cytoplasmic Domain

Product Categories/Family for anti-PTGDR antibody

Family: GPCR; Subfamily: Prostanoid

Applications Tested/Suitable for anti-PTGDR antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-PTGDR antibody

IHC-P (4 - 6 ug/ml)

Other Notes

Small volumes of anti-PTGDR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTGDR purchase

MBS242851 is an antibody targeting PTGDR. Also known as Rabbit Polyclonal to Human PTGDR / DP. Reactive in Human
Predicted Reactivity: Gorilla, Monkey (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTGDR. It may not necessarily be applicable to this product.

NCBI GI #

28466969

NCBI GeneID

5729

NCBI Accession #

NP_000944.1

UniProt Primary Accession #

Q13258

UniProt Secondary Accession #

Q13250; Q13251; Q1ZZ52; G3V5L3

UniProt Related Accession #

Q13258

GenBank Nucleotide #

NM_000953.2

NCBI Official Full Name

prostaglandin D2 receptor isoform 1

NCBI Official Synonym Full Names

prostaglandin D2 receptor (DP)

NCBI Official Symbol

PTGDR

NCBI Official Synonym Symbols

DP; AS1; DP1; ASRT1; PTGDR1

UniProt Protein Name

Prostaglandin D2 receptor

UniProt Synonym Protein Names

Prostanoid DP receptor

Protein Family

Prostaglandin D2 receptor

UniProt Gene Name

PTGDR

UniProt Synonym Gene Names

PGD receptor; PGD2 receptor

UniProt Entry Name

PD2R_HUMAN

NCBI Protein Information

prostaglandin D2 receptor; PGD2 receptor

NCBI Summary for PTGDR

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

UniProt Comments for PTGDR

PTGDR: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate. Genetic variations in PTGDR are associated with susceptibility to asthma-related traits type 1 (ASRT1). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 14q22.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding; prostaglandin J receptor activity; prostaglandin D receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; male sex determination; adenosine metabolic process; inflammatory response; sleep

Disease: Asthma-related Traits, Susceptibility To, 1

Research Articles on PTGDR

1. Low DP1 prostanoid receptor is associated with gastric cancer progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTGDR antibody

Reference Product	PubMed Publications
PTGIR antibody	>3 publications with PTGDR and PTGIR
ADRB2 antibody	>1 publications with PTGDR and ADRB2
NPSR1 antibody	>1 publications with PTGDR and NPSR1

Pathways associated with anti-PTGDR antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Eicosanoid Ligand-binding Receptors Pathway antibodies	Eicosanoid Ligand-binding Receptors Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-PTGDR antibody

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>23 publications with PTGDR and Lung Diseases
Inflammation Antibodies	>4 publications with PTGDR and Inflammation
Drug-Related Side Effects and Adverse Reactions Antibodies	>2 publications with PTGDR and Drug-Related Side Effects and Adverse Reactions
Cardiovascular Diseases Antibodies	>2 publications with PTGDR and Cardiovascular Diseases
Hyperplasia Antibodies	>2 publications with PTGDR and Hyperplasia
Disease Models, Animal Antibodies	>2 publications with PTGDR and Disease Models, Animal
Flushing Antibodies	>1 publications with PTGDR and Flushing
Atherosclerosis Antibodies	>1 publications with PTGDR and Atherosclerosis
Necrosis Antibodies	>1 publications with PTGDR and Necrosis
ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 1 Antibodies	>1 publications with PTGDR and ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 1

Organs/Tissues associated with anti-PTGDR antibody

Organ/Tissue Name	Pubmed Publications
Uterus Antibodies	>1 publications with PTGDR and Uterus
Liver Antibodies	>1 publications with PTGDR and Liver