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NEK6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242867

NEK6 encodes a NEK type protein kinase, which contains a C-terminal NIMA-like catalytic domain. The protein is believed to regulate chromatin condensation in mammalian cells via phosphorylation of histones H1 and H3, and it has been shown to phosphorylate… More details

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Product Overview

Online Datasheet in PDF
Product Name
NEK6, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human NEK6
Product Gene Name
anti-NEK6 antibody
Product Synonym Names
Anti-NEK6 Antibody (C-Terminus) IHC-plus; NEK6; NIMA-related kinase 6; Protein kinase SID6-1512; NimA-related protein kinase 6; SID6-1512; Human NEK6
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human NEK6. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except NEK7 (61%).
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
38,460 Da
OMIM
604884
3D Structure
ModBase 3D Structure for Q9HC98
Target Species
Human
Immunogen Description
Synthetic 18 amino acid peptide from near C-terminus of human NEK6. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bat, Rabbit, Horse, Xenopus (89%).
Immunogen Type
Synthetic peptide
Immunogen
NEK6 antibody was raised against synthetic 18 amino acid peptide from near C-terminus of human NEK6. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bat, Rabbit, Horse, Xenopus (89%); Pig, Opossum, Turkey, Chicken (83%).
Antigen Modification
C-Terminus

Product Categories/Family for anti-NEK6 antibody

Family: Protein Kinase; Subfamily: NEK
Applications Tested/Suitable for anti-NEK6 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-NEK6 antibody
IHC-P (13 ug/ml)

Immunohistochemistry (IHC) of anti-NEK6 antibody

Anti-NEK6 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-NEK6 Polyclonal Antibody – Cat# MBS242867

Immunohistochemistry (IHC) of anti-NEK6 antibody

Anti-NEK6 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-NEK6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242867

Immunohistochemistry (IHC) of anti-NEK6 antibody

Anti-NEK6 antibody IHC of human brain, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-NEK6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242867

Immunohistochemistry (IHC) of anti-NEK6 antibody

Anti-NEK6 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-NEK6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242867

Other Notes

Small volumes of anti-NEK6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NEK6 purchase

MBS242867 is an antibody targeting NEK6. Also known as Rabbit Polyclonal to Human NEK6. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NEK6. It may not necessarily be applicable to this product.

NCBI GI #
19923407
NCBI GeneID
10783
NCBI Accession #
NP_055212.2
UniProt Primary Accession #
Q9HC98
UniProt Secondary Accession #
Q5TBG3; Q5TBG9; Q6FG86; Q6IAR3; Q96E83; Q9ULX2; B7Z2D9
UniProt Related Accession #
Q9HC98
GenBank Nucleotide #
NM_014397.5
NCBI Official Full Name
serine/threonine-protein kinase Nek6 isoform 2
NCBI Official Synonym Full Names
NIMA-related kinase 6
NCBI Official Symbol
NEK6
NCBI Official Synonym Symbols
SID6-1512
UniProt Protein Name
Serine/threonine-protein kinase Nek6
UniProt Synonym Protein Names
Never in mitosis A-related kinase 6; NimA-related protein kinase 6; Protein kinase SID6-1512
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
NEK6
UniProt Synonym Gene Names
NimA-related protein kinase 6
UniProt Entry Name
NEK6_HUMAN
NCBI Protein Information
serine/threonine-protein kinase Nek6; protein kinase SID6-1512; nimA-related protein kinase 6; never in mitosis A-related kinase 6; putative serine-threonine protein kinase; NIMA (never in mitosis gene a)-related kinase 6

NCBI Summary for NEK6

The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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UniProt Comments for NEK6

NEK6: a protein kinase of the NEK family. Important in mitosis. May regulate spindle function.

Protein type: Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; NEK family

Chromosomal Location of Human Ortholog: 9q33.3-q34.11

Cellular Component: spindle pole; microtubule; cytoplasm; microtubule organizing center; nuclear speck; cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; signal transducer activity; kinesin binding; magnesium ion binding; protein kinase binding; ATP binding

Biological Process: mitosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; protein amino acid autophosphorylation; regulation of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; mitotic nuclear envelope disassembly; cytokinesis; spindle assembly; signal transduction; protein amino acid phosphorylation; chromosome segregation; peptidyl-serine phosphorylation; mitotic cell cycle; G2/M transition DNA damage checkpoint
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Research Articles on NEK6

1. Nek6 plays an important role in the premature senescence of cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NEK6 antibody

 Reference Product  PubMed Publications
 NEK9 antibody  >14 publications with NEK6 and NEK9
 KIF11 antibody  >2 publications with NEK6 and KIF11
 PIN1 antibody  >1 publications with NEK6 and PIN1
 LHX2 antibody  >1 publications with NEK6 and LHX2
 CRB2 antibody  >1 publications with NEK6 and CRB2

Pathways associated with anti-NEK6 antibody

 Products by Pathway  Pathway Diagram
 Activation Of NIMA Kinases NEK9, NEK6, NEK7 Pathway antibodies  Activation Of NIMA Kinases NEK9, NEK6, NEK7 Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Prophase Pathway antibodies  Mitotic Prophase Pathway Diagram
 Nuclear Envelope Breakdown Pathway antibodies  Nuclear Envelope Breakdown Pathway Diagram
 Nuclear Pore Complex (NPC) Disassembly Pathway antibodies  Nuclear Pore Complex (NPC) Disassembly Pathway Diagram

Diseases associated with anti-NEK6 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >5 publications with NEK6 and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >4 publications with NEK6 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >4 publications with NEK6 and Liver Neoplasms
 Liver Diseases Antibodies  >4 publications with NEK6 and Liver Diseases
 Neoplasms, Experimental Antibodies  >2 publications with NEK6 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >2 publications with NEK6 and Lung Neoplasms
 Fibrosis Antibodies  >1 publications with NEK6 and Fibrosis
 Hypertrophy Antibodies  >1 publications with NEK6 and Hypertrophy
 Liver Neoplasms, Experimental Antibodies  >1 publications with NEK6 and Liver Neoplasms, Experimental
 Skin Neoplasms Antibodies  >1 publications with NEK6 and Skin Neoplasms

Organs/Tissues associated with anti-NEK6 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >7 publications with NEK6 and Liver
 Lung Antibodies  >3 publications with NEK6 and Lung
 Spleen Antibodies  >2 publications with NEK6 and Spleen
 Muscle Antibodies  >2 publications with NEK6 and Muscle
 Heart Antibodies  >2 publications with NEK6 and Heart
 Embryonic Tissue Antibodies  >2 publications with NEK6 and Embryonic Tissue
 Brain Antibodies  >2 publications with NEK6 and Brain
 Uterus Antibodies  >1 publications with NEK6 and Uterus
 Testis Antibodies  >1 publications with NEK6 and Testis
 Stomach Antibodies  >1 publications with NEK6 and Stomach
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