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LAIR1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242910

MBS242910 is an antibody targeting LAIR1. Also known as Goat Polyclonal to Human LAIR1 / CD305. Reactive in Human. Host: Goat. More details

$680 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LAIR1 / CD305, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human LAIR1 / CD305
Product Gene Name
Product Synonym Gene Name
CD305
Product Synonym Names
Anti-LAIR1 / CD305 Antibody (Internal) IHC-plus; LAIR1; CD305; CD305 antigen; HLAIR1; LAIR-1; Human LAIR1; CD305
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human LAIR1 / LAIR-1. This antibody is expected to recognize both isoforms (NP_002278.1; NP_068352.1).
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
23,049 Da
OMIM
602992
3D Structure
ModBase 3D Structure for Q6GTX8
Target Species
Human
Immunogen Description
Synthetic peptide C-NDTEDVSQASPSE from an internal region of human LAIR1 / LAIR-1 (NP_002278.1; NP_068352.1). Percent identity with other species by BLAST analysis: Human (100%).
Immunogen Type
Synthetic peptide
Immunogen
LAIR1 / CD305 antibody was raised against synthetic peptide C-NDTEDVSQASPSE from an internal region of human LAIR1 / LAIR-1 (NP_002278.1; NP_068352.1). Percent identity with other species by BLAST analysis: Human (100%).
Antigen Modification
Internal

Product Categories/Family for anti-LAIR1 antibody

Applications Tested/Suitable for anti-LAIR1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-LAIR1 antibody
ELISA (1:1000), IHC-P (3.75 ug/ml), WB (1 - 3 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:1000. Western blot: Approx 28kDa band observed in Human Lymph Node lysates (calculated MW of 29.8kDa according to NP_068352.1). Recommended concentration: 1-3 ug/ml.

Immunohistochemistry (IHC) of anti-LAIR1 antibody

Anti-CD305 / LAIR-1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3.75 ug/ml.
Goat Anti-LAIR1 Polyclonal Antibody – Cat# MBS242910

Western Blot (WB) of anti-LAIR1 antibody

LAIR1 antibody (2 ug/ml) staining of Human Lymph Node lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-LAIR1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS242910

Other Notes

Small volumes of anti-LAIR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LAIR1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
leukocyte-associated immunoglobulin-like receptor 1 isoform c
NCBI Official Synonym Full Names
leukocyte-associated immunoglobulin-like receptor 1
NCBI Official Symbol
LAIR1
NCBI Official Synonym Symbols
CD305; LAIR-1
UniProt Protein Name
Leukocyte-associated immunoglobulin-like receptor 1
UniProt Synonym Protein Names
CD_antigen: CD305
UniProt Gene Name
LAIR1
UniProt Synonym Gene Names
CD305; LAIR-1; hLAIR1
UniProt Entry Name
LAIR1_HUMAN
NCBI Protein Information
leukocyte-associated immunoglobulin-like receptor 1; leukocyte-associated Ig-like receptor 1

NCBI Summary for LAIR1

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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UniProt Comments for LAIR1

LAIR-1: an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region called the leukocyte receptor cluster, which contains at least 25 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: immune system process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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