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CXADR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242958

The Coxsackievirus and adenovirus receptor (CAR) is a membrane glycoprotein with a cytoplasmic domain, a transmembrane domain and an extracellular region consisting of two immunoglobulin-like domains, an amino-terminal immunoglobulin variable (IgV)-related… More details

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Product Overview

Online Datasheet in PDF
Product Name
CXADR, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human CXADR
Product Gene Name
anti-CXADR antibody
Product Synonym Names
Anti-CXADR Antibody (Internal) IHC-plus; CXADR; CAR4/6; Coxsackie-adenovirus receptor; CVB3-binding protein; CAR; HCAR; HCVADR; Human CXADR
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Chimpanzee, Gorilla, Human, Orangutan
Predicted Reactivity: Monkey, Horse (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human CXADR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
35,570 Da
OMIM
602621
3D Structure
ModBase 3D Structure for P78310
Target Species
Human
Immunogen Description
Synthetic 15 amino acid peptide from internal region of human CXADR. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon (100%); Monkey, Galago, Horse (93%); Marmoset, Mouse, Elephant, Panda, Bat.
Immunogen Type
Synthetic peptide
Immunogen
CXADR antibody was raised against synthetic 15 amino acid peptide from internal region of human CXADR. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon (100%); Monkey, Galago, Horse (93%); Marmoset, Mouse, Elephant, Panda, Bat, Bovine, Rabbit, Pig, Guinea pig (87%); Rat, Hamster (80%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-CXADR antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-CXADR antibody
IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-CXADR antibody

Anti-CXADR antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CXADR Polyclonal Antibody – Cat# MBS242958

Immunohistochemistry (IHC) of anti-CXADR antibody

Anti-CXADR antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CXADR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242958

Other Notes

Small volumes of anti-CXADR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXADR purchase

MBS242958 is an antibody targeting CXADR. Also known as Rabbit Polyclonal to Human CXADR. Reactive in Gibbon, Chimpanzee, Gorilla, Human, Orangutan
Predicted Reactivity: Monkey, Horse (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CXADR. It may not necessarily be applicable to this product.

NCBI GI #
4503173
NCBI GeneID
1525
NCBI Accession #
NP_001329.1
UniProt Primary Accession #
P78310
UniProt Secondary Accession #
O00694; Q8WWT6; Q8WWT7; Q8WWT8; Q9UKV4; B2R8V8; B7WPI3; D3YHP0
UniProt Related Accession #
P78310
GenBank Nucleotide #
NM_001338.4
NCBI Official Full Name
coxsackievirus and adenovirus receptor isoform 1
NCBI Official Synonym Full Names
coxsackie virus and adenovirus receptor
NCBI Official Symbol
CXADR
NCBI Official Synonym Symbols
CAR; HCAR; CAR4/6
UniProt Protein Name
Coxsackievirus and adenovirus receptor
UniProt Synonym Protein Names
CVB3-binding protein; Coxsackievirus B-adenovirus receptor; HCVADR
Protein Family
Coxsackievirus and adenovirus receptor
UniProt Gene Name
CXADR
UniProt Synonym Gene Names
CAR; CAR; hCAR
UniProt Entry Name
CXAR_HUMAN
NCBI Protein Information
coxsackievirus and adenovirus receptor; HCVADR; CVB3-binding protein; coxsackievirus B-adenovirus receptor; 46 kD coxsackievirus and adenovirus receptor (CAR) protein

NCBI Summary for CXADR

The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
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UniProt Comments for CXADR

CXADR: a component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1 located in the plasma membrane of PMN.

Protein type: Cell adhesion; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 21q21.1

Cellular Component: extracellular space; neuron projection; tight junction; protein complex; basolateral plasma membrane; apicolateral plasma membrane; integral to plasma membrane; acrosome; extracellular region; intercellular junction; lipid raft; nucleoplasm; adherens junction; growth cone; plasma membrane; cell junction; neuromuscular junction; filopodium

Molecular Function: viral receptor activity; integrin binding; identical protein binding; protein binding; beta-catenin binding; cell adhesion molecule binding; receptor binding; PDZ domain binding

Biological Process: mitochondrion organization and biogenesis; neutrophil chemotaxis; intercellular junction assembly and maintenance; regulation of immune response; entry of virus into host cell; heart development; gamma-delta T cell activation; heterophilic cell adhesion; cardiac muscle fiber development; homotypic cell-cell adhesion; actin cytoskeleton reorganization; germ cell migration; blood coagulation; leukocyte migration; defense response to virus
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Research Articles on CXADR

1. This study shows for the first time that lovastatin reduces the expression of CAR and subsequently the replication of CVB3 in human umbilical vein endothelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXADR antibody

 Reference Product  PubMed Publications
 LNX1 antibody  >1 publications with CXADR and LNX1

Pathways associated with anti-CXADR antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Viral Myocarditis Pathway antibodies  Viral Myocarditis Pathway Diagram

Diseases associated with anti-CXADR antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >4 publications with CXADR and Heart Diseases
 Cardiovascular Diseases Antibodies  >4 publications with CXADR and Cardiovascular Diseases
 Edema Antibodies  >1 publications with CXADR and Edema
 Heart Failure Antibodies  >1 publications with CXADR and Heart Failure
 Hypertension Antibodies  >1 publications with CXADR and Hypertension
 Inflammation Antibodies  >1 publications with CXADR and Inflammation

Organs/Tissues associated with anti-CXADR antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >6 publications with CXADR and Heart
 Lung Antibodies  >3 publications with CXADR and Lung
 Testis Antibodies  >3 publications with CXADR and Testis
 Brain Antibodies  >3 publications with CXADR and Brain
 Embryonic Tissue Antibodies  >2 publications with CXADR and Embryonic Tissue
 Kidney Antibodies  >1 publications with CXADR and Kidney
 Stomach Antibodies  >1 publications with CXADR and Stomach
 Eye Antibodies  >1 publications with CXADR and Eye
 Muscle Antibodies  >1 publications with CXADR and Muscle
 Ovary Antibodies  >1 publications with CXADR and Ovary
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