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PGLYRP1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242963

MBS242963 is an antibody targeting PGLYRP1. Also known as Goat Polyclonal to Human PGLYRP1 / PGRP. Reactive in Human. Host: Goat. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PGLYRP1 / PGRP, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human PGLYRP1 / PGRP
Product Gene Name
anti-PGLYRP1 antibody
Product Synonym Gene Name
PGRP
Product Synonym Names
Anti-PGLYRP1 / PGRP Antibody (C-Terminus) IHC-plus; PGLYRP1; PGLYRP; PGRPS; TAG7; PGRP; PGRP-S; TNFSF3L; Human PGLYRP1; PGRP
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human PGLYRP1 / PGRP.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
21,731 Da
OMIM
604963
3D Structure
ModBase 3D Structure for O75594
Target Species
Human
Immunogen Description
Synthetic peptide C-PGNQLYHLIQN from the C-terminus of human PGLYRP1 / PGRP (NP_005082.1). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (82%), Gibbon (82%), Monkey (82%), Ant (82%).
Immunogen Type
Synthetic peptide
Immunogen
PGLYRP1 / PGRP antibody was raised against synthetic peptide C-PGNQLYHLIQN from the C-terminus of human PGLYRP1 / PGRP (NP_005082.1). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (82%), Gibbon (82%), Monkey (82%), Ant (82%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-PGLYRP1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-PGLYRP1 antibody
ELISA (1:4000, 0.3 - 1 ug/ml), IHC-P (3.75 ug/ml), WB (0.3 - 1 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:4000. Western Blot: Approx 30kD band observed in lysates of cell line Jurkat (calculated MW of 21.7kD according to NP_005082.1). The observed molecular weight corresponds to earlier findings in liter...

Immunohistochemistry (IHC) of anti-PGLYRP1 antibody

Anti-PGLYRP1 / PGRP antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-PGLYRP1 Polyclonal Antibody – Cat# MBS242963

Western Blot (WB) of anti-PGLYRP1 antibody

Antibody (0.3 ug/ml) staining of Jurkat lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-PGLYRP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS242963

Other Notes

Small volumes of anti-PGLYRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PGLYRP1. It may not necessarily be applicable to this product.

NCBI GI #
4827036
NCBI GeneID
8993
NCBI Accession #
NP_005082.1
UniProt Primary Accession #
O75594
UniProt Secondary Accession #
Q4VB36
UniProt Related Accession #
O75594
GenBank Nucleotide #
NM_005091.2
NCBI Official Full Name
peptidoglycan recognition protein 1
NCBI Official Synonym Full Names
peptidoglycan recognition protein 1
NCBI Official Symbol
PGLYRP1
NCBI Official Synonym Symbols
PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L
UniProt Protein Name
Peptidoglycan recognition protein 1
UniProt Synonym Protein Names
Peptidoglycan recognition protein short; PGRP-S
Protein Family
Peptidoglycan recognition protein
UniProt Gene Name
PGLYRP1
UniProt Synonym Gene Names
PGLYRP; PGRP; TNFSF3L; PGRP-S
UniProt Entry Name
PGRP1_HUMAN
NCBI Protein Information
peptidoglycan recognition protein 1; TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)

UniProt Comments for PGLYRP1

PGLYRP1: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Protein type: Receptor, misc.; Secreted, signal peptide; Secreted; Apoptosis

Chromosomal Location of Human Ortholog: 19q13.2-q13.3

Cellular Component: extracellular region

Molecular Function: peptidoglycan receptor activity; peptidoglycan binding; zinc ion binding; N-acetylmuramoyl-L-alanine amidase activity

Biological Process: defense response to Gram-positive bacterium; negative regulation of natural killer cell differentiation during immune response; detection of bacterium; negative regulation of interferon-gamma production; negative regulation of inflammatory response; innate immune response; immune response; pattern recognition receptor signaling pathway; peptidoglycan catabolic process
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Research Articles on PGLYRP1

1. shown that HspBP1 binds Tag7 in the conditioned medium of tumor CSML0 cells, thereby preventing formation of the cytotoxic Tag7-Hsp70 complex

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PGLYRP1 antibody

 Reference Product  PubMed Publications
 HSPBP1 antibody  >3 publications with PGLYRP1 and HSPBP1
 S100A4 antibody  >3 publications with PGLYRP1 and S100A4
 NOD2 antibody  >2 publications with PGLYRP1 and NOD2
 NOD1 antibody  >1 publications with PGLYRP1 and NOD1

Diseases associated with anti-PGLYRP1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with PGLYRP1 and Inflammation
 Disease Models, Animal Antibodies  >7 publications with PGLYRP1 and Disease Models, Animal
 Necrosis Antibodies  >6 publications with PGLYRP1 and Necrosis
 Adenocarcinoma Antibodies  >3 publications with PGLYRP1 and Adenocarcinoma
 Carcinoma Antibodies  >2 publications with PGLYRP1 and Carcinoma
 Respiratory Hypersensitivity Antibodies  >2 publications with PGLYRP1 and Respiratory Hypersensitivity
 Lung Diseases Antibodies  >2 publications with PGLYRP1 and Lung Diseases
 Hyperplasia Antibodies  >2 publications with PGLYRP1 and Hyperplasia
 Neoplasms, Experimental Antibodies  >1 publications with PGLYRP1 and Neoplasms, Experimental
 Liver Diseases Antibodies  >1 publications with PGLYRP1 and Liver Diseases

Organs/Tissues associated with anti-PGLYRP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with PGLYRP1 and Blood
 Bone Marrow Antibodies  >2 publications with PGLYRP1 and Bone Marrow
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