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HAUSP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243015

Ubiquitin-specific protease 7 (USP7) as a cysteine protease removes ubiquitin from conjugates and has been shown to regulate the levels of tumor suppressor protein p53 by deubiquitinating MDM2 (a ubiquitin ligase). USP7 is also known as herpes… More details

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Product Overview

Product Name
HAUSP / USP7, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human HAUSP / USP7
Product Gene Name
anti-HAUSP antibody
Product Synonym Gene Name
USP7
Product Synonym Names
Anti-HAUSP / USP7 Antibody (aa1050-1100) IHC-plus; USP7; Deubiquitinating enzyme 7; HAUSP; TEF1; Ubiquitin specific protease 7; Ubiquitin thioesterase 7; Human HAUSP; USP7
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Chimpanzee, Chicken, Dog, Horse, Human, Macaque, Mouse, Rat
Form/Format
PBS, 0.05% BSA, 0.05% sodium azide
Purity/Purification
Protein A Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human USP7
Preparation and Storage
Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
Molecular Weight
– Da
OMIM
602519
3D Structure
ModBase 3D Structure for Q93009
Target Species
Human
Immunogen Description
A portion of amino acids 1050-1100 of human USP7 protein was used as the immunogen.
Immunogen Type
Synthetic peptide
Immunogen
HAUSP / USP7 antibody was raised against a portion of amino acids 1050-1100 of human USP7 protein was used as the immunogen.
Antigen Modification
aa1050-1100

Product Categories/Family for anti-HAUSP antibody

Family: Protease; Subfamily: Cysteine C19
Applications Tested/Suitable for anti-HAUSP antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-HAUSP antibody
IHC-P (10 ug/ml), WB (1 - 2 ug/ml)

Immunohistochemistry (IHC) of anti-HAUSP antibody

Anti-USP7 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-HAUSP Polyclonal Antibody – Cat# MBS243015

Immunohistochemistry (IHC) of anti-HAUSP antibody

Anti-USP7 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-HAUSP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243015

Western Blot (WB) of anti-HAUSP antibody

Western blot of USP7 protein in MCF7 cell lysate in the 1) absence and 2) presence of immunizing peptide using at 1.0 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
Rabbit Anti-HAUSP Polyclonal Antibody, Western Blot (WB) – Cat# MBS243015

Other Notes

Small volumes of anti-HAUSP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HAUSP purchase

MBS243015 is an antibody targeting HAUSP. Also known as Rabbit Polyclonal to Human HAUSP / USP7. Reactive in Chimpanzee, Chicken, Dog, Horse, Human, Macaque, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HAUSP. It may not necessarily be applicable to this product.

NCBI GI #
150378533
NCBI GeneID
7874
NCBI Accession #
NP_003461.2
UniProt Primary Accession #
Q93009
UniProt Secondary Accession #
A6NMY8; B7Z815; H0Y3G8
UniProt Related Accession #
Q93009
GenBank Nucleotide #
NM_003470.2
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase 7 isoform 1
NCBI Official Synonym Full Names
ubiquitin specific peptidase 7 (herpes virus-associated)
NCBI Official Symbol
USP7
NCBI Official Synonym Symbols
TEF1; HAUSP
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 7
UniProt Synonym Protein Names
Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7
UniProt Gene Name
USP7
UniProt Synonym Gene Names
HAUSP
UniProt Entry Name
UBP7_HUMAN
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 7; ubiquitin thioesterase 7; deubiquitinating enzyme 7; ubiquitin-specific-processing protease 7; herpesvirus-associated ubiquitin-specific protease; Herpes virus-associated ubiquitin-specific protease; ubiquitin specific protease 7 (herpes virus-associated)

UniProt Comments for HAUSP

USP7: an enzyme that removes ubiquitin from its protein substrates. Binds to the herpes virus protein VMW110 that may therefore modulate its substrate specificity or activity to stabilize viral proteins. Regulates MDM2 and has a dynamic role in the p53-MDM2 pathway. Is reported to deubiquitinate and stabilize p53.

Protein type: EC 3.4.19.12; Ubiquitin-specific protease; Ubiquitin conjugating system; Protease

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: nuclear body; PML body; nucleus; cytosol

Molecular Function: protein C-terminus binding; protein binding; p53 binding; ubiquitin protein ligase binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; transcription factor binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; viral reproduction; regulation of transcription factor activity; maintenance of DNA methylation; inhibition of NF-kappaB transcription factor; transcription-coupled nucleotide-excision repair; multicellular organismal development; histone deubiquitination
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Research Articles on HAUSP

1. findings uncovered an important role of USP7 in regulating NER via deubiquitinating XPC and by preventing its VCP/p97-regulated proteolysis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HAUSP antibody

 Reference Product  PubMed Publications
 MDM2 antibody  >51 publications with HAUSP and MDM2
 TP53 antibody  >11 publications with HAUSP and TP53
 DAXX antibody  >7 publications with HAUSP and DAXX
 MDM4 antibody  >6 publications with HAUSP and MDM4
 DNMT1 antibody  >6 publications with HAUSP and DNMT1
 FOXO4 antibody  >5 publications with HAUSP and FOXO4
 GMPS antibody  >5 publications with HAUSP and GMPS
 USP11 antibody  >1 publications with HAUSP and USP11
 UBC antibody  >1 publications with HAUSP and UBC

Pathways associated with anti-HAUSP antibody

 Products by Pathway  Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 FoxO Family Signaling Pathway antibodies  FoxO Family Signaling Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Viral Carcinogenesis Pathway antibodies  Viral Carcinogenesis Pathway Diagram
 Viral Carcinogenesis Pathway antibodies  Viral Carcinogenesis Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram

Diseases associated with anti-HAUSP antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >16 publications with HAUSP and Death
 Necrosis Antibodies  >10 publications with HAUSP and Necrosis
 Nervous System Diseases Antibodies  >9 publications with HAUSP and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >8 publications with HAUSP and Cell Transformation, Neoplastic
 Cardiovascular Diseases Antibodies  >5 publications with HAUSP and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with HAUSP and Inflammation
 Prostatic Diseases Antibodies  >3 publications with HAUSP and Prostatic Diseases
 Lung Diseases Antibodies  >3 publications with HAUSP and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with HAUSP and Carcinoma, Hepatocellular
 Brain Diseases Antibodies  >2 publications with HAUSP and Brain Diseases

Organs/Tissues associated with anti-HAUSP antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >10 publications with HAUSP and Lung
 Blood Antibodies  >9 publications with HAUSP and Blood
 Prostate Antibodies  >5 publications with HAUSP and Prostate
 Kidney Antibodies  >5 publications with HAUSP and Kidney
 Liver Antibodies  >5 publications with HAUSP and Liver
 Brain Antibodies  >5 publications with HAUSP and Brain
 Skin Antibodies  >3 publications with HAUSP and Skin
 Testis Antibodies  >3 publications with HAUSP and Testis
 Embryonic Tissue Antibodies  >2 publications with HAUSP and Embryonic Tissue
 Vascular Antibodies  >2 publications with HAUSP and Vascular
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