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NPFF2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243056

The Neuropeptide FF 2 Receptor (NPFF2/HLWAR77/NPGPR) is a Neuropeptide Receptor GPCR. This receptor has high affinity for NPAF and NPFF, and is also weakly activated by FMRF-amide (Phe-Met-Arg-Phe-amide) and a variety of related peptides. More details

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Product Overview

Online Datasheet in PDF
Product Name
NPFF2 / NPFFR2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human NPFF2 / NPFFR2
Product Gene Name
anti-NPFF2 antibody
Product Synonym Gene Name
NPFFR2
Product Synonym Names
Anti-NPFF2 / NPFFR2 Antibody (Extracellular Domain) IHC-plus; NPFFR2; G protein-coupled receptor 74; HLWAR77; G-protein coupled receptor 74; Neuropeptide FF receptor 2; Neuropeptide FF 2; NPFF2; Neuropeptide FF 2 receptor; NPGPR; GPR74; NPFF-R2; NPFF2 receptor; NPGP receptor; Human NPFF2; NPFFR2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Horse, Human
Predicted Reactivity: Monkey, Pig, Rabbit (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human NPFFR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
15,055 Da
OMIM
607449
3D Structure
ModBase 3D Structure for Q9Y5X5
Target Species
Human
Immunogen Description
Synthetic 18 amino acid peptide from 3rd extracellular domain of human NPFFR2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Horse (100%); Monkey, Elephant, Rabbit, Pig (94%); Dog, Bovine (89%).
Immunogen Type
Synthetic peptide
Immunogen
NPFF2 / NPFFR2 antibody was raised against synthetic 18 amino acid peptide from 3rd extracellular domain of human NPFFR2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Horse (100%); Monkey, Elephant, Rabbit, Pig (94%); Dog, Bovine (89%); Mouse, Rat, Panda, Bat (83%).
Antigen Modification
Extracellular Domain

Product Categories/Family for anti-NPFF2 antibody

Family: GPCR; Subfamily: Neuropeptide
Applications Tested/Suitable for anti-NPFF2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-NPFF2 antibody
IHC-P (16 ug/ml)

Immunohistochemistry (IHC) of anti-NPFF2 antibody

Anti-NPFFR2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-NPFF2 Polyclonal Antibody – Cat# MBS243056

Immunohistochemistry (IHC) of anti-NPFF2 antibody

Anti-NPFF2 / NPFFR2 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-NPFF2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243056

Immunohistochemistry (IHC) of anti-NPFF2 antibody

Anti-NPFF2 / NPFFR2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-NPFF2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243056

Immunohistochemistry (IHC) of anti-NPFF2 antibody

Anti-NPFF2 / NPFFR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-NPFF2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243056

Other Notes

Small volumes of anti-NPFF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NPFF2 purchase

MBS243056 is an antibody targeting NPFF2. Also known as Rabbit Polyclonal to Human NPFF2 / NPFFR2. Reactive in Gibbon, Gorilla, Horse, Human
Predicted Reactivity: Monkey, Pig, Rabbit (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NPFF2. It may not necessarily be applicable to this product.

NCBI GI #
221316654
NCBI GeneID
10886
NCBI Accession #
NP_004876.2
UniProt Primary Accession #
Q9Y5X5
UniProt Secondary Accession #
Q96RV1; Q9NR49
UniProt Related Accession #
Q9Y5X5
GenBank Nucleotide #
NM_004885.2
NCBI Official Full Name
neuropeptide FF receptor 2 isoform 1
NCBI Official Synonym Full Names
neuropeptide FF receptor 2
NCBI Official Symbol
NPFFR2
NCBI Official Synonym Symbols
GPR74; NPFF2; NPGPR; HLWAR77
UniProt Protein Name
Neuropeptide FF receptor 2
UniProt Synonym Protein Names
G-protein coupled receptor 74; G-protein coupled receptor HLWAR77; Neuropeptide G-protein coupled receptor
UniProt Gene Name
NPFFR2
UniProt Synonym Gene Names
GPR74; NPFF2; NPGPR
UniProt Entry Name
NPFF2_HUMAN
NCBI Protein Information
neuropeptide FF receptor 2; neuropeptide FF 2; G protein-coupled receptor 74; G-protein coupled receptor 74; G-protein coupled receptor HLWAR77; neuropeptide G-protein coupled receptor

NCBI Summary for NPFF2

This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
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UniProt Comments for NPFF2

NPFFR2: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: integral to plasma membrane; plasma membrane; actin cytoskeleton

Molecular Function: G-protein coupled receptor activity; opioid receptor binding; neuropeptide receptor activity; peptide binding

Biological Process: regulation of adenylate cyclase activity; synaptic transmission; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; regulation of MAPKKK cascade; detection of abiotic stimulus; cellular response to hormone stimulus
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Research Articles on NPFF2

1. These data show that NPFF-induced heterologous desensitization of MOP receptor signaling is mediated by GRK2 and could involve transphosphorylation within the heteromeric receptor complex.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NPFF2 antibody

 Reference Product  PubMed Publications
 NPFFR1 antibody  >4 publications with NPFF2 and NPFFR1
 NPFF antibody  >4 publications with NPFF2 and NPFF
 KISS1R antibody  >1 publications with NPFF2 and KISS1R
 QRFPR antibody  >1 publications with NPFF2 and QRFPR

Pathways associated with anti-NPFF2 antibody

 Products by Pathway  Pathway Diagram
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 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-NPFF2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with NPFF2 and Inflammation

Organs/Tissues associated with anti-NPFF2 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with NPFF2 and Bone
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