• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

NR1D2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243059

Rev-erbA beta, a NR1 Thyroid Hormone-Like Receptor, has been shown to affect cell proliferation, organ physiology, and myogenesis. Rev-erbA beta has been shown to be a constitutive repressor and binds as a monomer or homodimer to target DNA, such as the n-myc… More details

$630 / 0.05 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NR1D2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human NR1D2
Product Gene Name
anti-NR1D2 antibody
Product Synonym Names
Anti-NR1D2 Antibody (Ligand-binding Domain) IHC-plus; NR1D2; EAR-1R; HZF2; Nuclear receptor rvr; Rev-erbabeta; Rev-erb-beta; Rev-erba beta; RVR; BD73; Nuclear receptor ear-1r; Human NR1D2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bat, Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey, Rabbit
Predicted Reactivity: Mouse, Rat (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human NR1D2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
64,625 Da
OMIM
602304
3D Structure
ModBase 3D Structure for Q14995
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from ligand-binding domain of human NR1D2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bovine, Dog, Bat, Panda, Horse, Rabbit, Opossum, Platypus (100%).
Immunogen Type
Synthetic peptide
Immunogen
NR1D2 antibody was raised against synthetic 17 amino acid peptide from ligand-binding domain of human NR1D2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bovine, Dog, Bat, Panda, Horse, Rabbit, Opossum, Platypus (100%); Mouse, Rat, Elephant (94%); Chicken (82%).
Antigen Modification
Ligand-binding Domain

Product Categories/Family for anti-NR1D2 antibody

Family: NHR; Subfamily: NR1 Thyroid hormone-like
Applications Tested/Suitable for anti-NR1D2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-NR1D2 antibody
IHC-P (4 - 7 ug/ml)

Immunohistochemistry (IHC) of anti-NR1D2 antibody

Anti-NR1D2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-NR1D2 Polyclonal Antibody – Cat# MBS243059

Immunohistochemistry (IHC) of anti-NR1D2 antibody

Anti-NR1D2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-NR1D2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243059

Other Notes

Small volumes of anti-NR1D2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NR1D2 purchase

MBS243059 is an antibody targeting NR1D2. Also known as Rabbit Polyclonal to Human NR1D2. Reactive in Bat, Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey, Rabbit
Predicted Reactivity: Mouse, Rat (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NR1D2. It may not necessarily be applicable to this product.

NCBI GI #
224177491
NCBI GeneID
9975
NCBI Accession #
NP_005117.3
UniProt Primary Accession #
Q14995
UniProt Secondary Accession #
O00402; Q86XD4; B2R8Q3
UniProt Related Accession #
Q14995
GenBank Nucleotide #
NM_005126.4
NCBI Official Full Name
nuclear receptor subfamily 1 group D member 2 isoform 1
NCBI Official Synonym Full Names
nuclear receptor subfamily 1, group D, member 2
NCBI Official Symbol
NR1D2
NCBI Official Synonym Symbols
RVR; BD73; EAR-1R
UniProt Protein Name
Nuclear receptor subfamily 1 group D member 2
UniProt Synonym Protein Names
Orphan nuclear hormone receptor BD73; Rev-erb alpha-related receptor; RVR; Rev-erb-beta; V-erbA-related protein 1-related; EAR-1R
Protein Family
Nuclear receptor subfamily
UniProt Gene Name
NR1D2
UniProt Synonym Gene Names
RVR; EAR-1R
UniProt Entry Name
NR1D2_HUMAN
NCBI Protein Information
nuclear receptor subfamily 1 group D member 2; rev-erb-beta; rev-erb alpha-related receptor; rev-erba-alpha-related receptor; V-erbA-related protein 1-related; orphan nuclear hormone receptor BD73; nuclear receptor Rev-ErbA beta variant 1; nuclear receptor Rev-ErbA beta variant 2

NCBI Summary for NR1D2

This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Show more

UniProt Comments for NR1D2

NR1D2: Binds to the sequences 5'-AATGTAGGTCA-3' and 5'- ATAACTAGGTCA-3'. Acts as a potent competitive repressor of ROR alpha function. Belongs to the nuclear hormone receptor family. NR1 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 3p24.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; zinc ion binding; steroid hormone receptor activity

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of lipid metabolic process; intracellular receptor-mediated signaling pathway; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of inflammatory response; rhythmic process; lipid homeostasis; gene expression; steroid hormone mediated signaling; regulation of circadian rhythm; negative regulation of transcription, DNA-dependent
Show more

Research Articles on NR1D2

1. Cobalt protoporphyrin IX (CoPP) and zinc protoporphyrin IX (ZnPP) are ligands that bind directly to the REV-ERBs. However, instead of mimicking the agonist action of heme, CoPP and ZnPP function as antagonists of REV-ERB function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NR1D2 antibody

 Reference Product  PubMed Publications
 NR1D1 antibody  >25 publications with NR1D2 and NR1D1
 RORA antibody  >4 publications with NR1D2 and RORA
 RORC antibody  >3 publications with NR1D2 and RORC
 THRB antibody  >1 publications with NR1D2 and THRB
 THRA antibody  >1 publications with NR1D2 and THRA
 NCOR1 antibody  >1 publications with NR1D2 and NCOR1

Pathways associated with anti-NR1D2 antibody

 Products by Pathway  Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram

Diseases associated with anti-NR1D2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with NR1D2 and Inflammation
 Disease Models, Animal Antibodies  >4 publications with NR1D2 and Disease Models, Animal
 Nervous System Diseases Antibodies  >3 publications with NR1D2 and Nervous System Diseases
 Liver Diseases Antibodies  >2 publications with NR1D2 and Liver Diseases
 Carcinoma Antibodies  >1 publications with NR1D2 and Carcinoma
 Cardiovascular Diseases Antibodies  >1 publications with NR1D2 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with NR1D2 and Carcinoma, Hepatocellular
 Hypertrophy Antibodies  >1 publications with NR1D2 and Hypertrophy
 Hyperplasia Antibodies  >1 publications with NR1D2 and Hyperplasia
 Fatty Liver Antibodies  >1 publications with NR1D2 and Fatty Liver

Organs/Tissues associated with anti-NR1D2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >10 publications with NR1D2 and Muscle
 Liver Antibodies  >9 publications with NR1D2 and Liver
 Blood Antibodies  >5 publications with NR1D2 and Blood
 Brain Antibodies  >5 publications with NR1D2 and Brain
 Thyroid Antibodies  >4 publications with NR1D2 and Thyroid
 Connective Tissue Antibodies  >3 publications with NR1D2 and Connective Tissue
 Nerve Antibodies  >2 publications with NR1D2 and Nerve
 Kidney Antibodies  >1 publications with NR1D2 and Kidney
 Bone Antibodies  >1 publications with NR1D2 and Bone
 Skin Antibodies  >1 publications with NR1D2 and Skin
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000