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MtTFA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243067

This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the… More details

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Product Overview

Product Name
MtTFA / TFAM, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human MtTFA / TFAM
Product Gene Name
anti-MtTFA antibody
Product Synonym Gene Name
TFAM
Product Synonym Names
Anti-MtTFA / TFAM Antibody (aa131-180) IHC-plus; TFAM; MTTF1; TCF-6; TCF6; TCF6L1; Transcription factor 6-like 2; Transcription factor 6-like 3; TCF6L2; TCF6L3; Transcription factor 6; Transcription factor 6-like 1; MTTFA; Human MtTFA; TFAM
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
TFAM Antibody detects endogenous levels of total TFAM protein.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
25,466 Da
OMIM
600438
3D Structure
ModBase 3D Structure for Q00059
Target Species
Human
Immunogen Description
Synthetic peptide from human TFAM (aa131-180).
Immunogen
MtTFA / TFAM antibody was raised against synthetic peptide from human TFAM (aa131-180).
Antigen Modification
aa131-180

Product Categories/Family for anti-MtTFA antibody

Family: Transcription factor
Applications Tested/Suitable for anti-MtTFA antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-MtTFA antibody
ELISA (1:20000), IF (1:100 - 1:500), IHC-P (10 ug/ml)

Immunohistochemistry (IHC) of anti-MtTFA antibody

Anti-TFAM antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-MtTFA Polyclonal Antibody – Cat# MBS243067

Immunofluorescence (IF) of anti-MtTFA antibody

Immunofluorescence of HepG2 cells, using TFAM Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-MtTFA Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS243067

Other Notes

Small volumes of anti-MtTFA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MtTFA purchase

MBS243067 is an antibody targeting MtTFA. Also known as Rabbit Polyclonal (IgG) to Human MtTFA / TFAM. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MtTFA. It may not necessarily be applicable to this product.

NCBI GI #
4507401
NCBI GeneID
7019
NCBI Accession #
NP_003192.1
UniProt Primary Accession #
Q00059
UniProt Secondary Accession #
Q5U0C6; A8MRB2; A9QXC6; B5BU05
UniProt Related Accession #
Q00059
GenBank Nucleotide #
NM_003201.2
NCBI Official Full Name
transcription factor A, mitochondrial isoform 1
NCBI Official Synonym Full Names
transcription factor A, mitochondrial
NCBI Official Symbol
TFAM
NCBI Official Synonym Symbols
TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3
UniProt Protein Name
Transcription factor A, mitochondrial
UniProt Synonym Protein Names
Mitochondrial transcription factor 1; MtTF1; Transcription factor 6; TCF-6; Transcription factor 6-like 2
UniProt Gene Name
TFAM
UniProt Synonym Gene Names
TCF6; TCF6L2; mtTFA; MtTF1; TCF-6
UniProt Entry Name
TFAM_HUMAN
NCBI Protein Information
transcription factor A, mitochondrial; transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 3; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcription factor 6-like 2 (mitochondrial transcription factor)

NCBI Summary for MtTFA

This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
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UniProt Comments for MtTFA

TFAM: regulates mitochondrial transcription. Induced in humans by caloric restriction. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Involved in cisplatin resistance. Interacts with TFB1M and TFB2M.

Protein type: Transcription regulation; DNA-binding

Chromosomal Location of Human Ortholog: 10q21

Cellular Component: mitochondrion; mitochondrial matrix; nucleus; cytosol

Molecular Function: protein binding; heat shock protein binding; chromatin binding; DNA bending activity; transcription factor activity

Biological Process: mitochondrial respiratory chain complex assembly; chromatin remodeling; mitochondrion organization and biogenesis; regulation of transcription from RNA polymerase I promoter; organelle organization and biogenesis; positive regulation of transcription, DNA-dependent; gene expression; positive regulation of transcription from RNA polymerase II promoter; DNA-dependent DNA replication; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter
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Research Articles on MtTFA

1. Data suggest that miitochondrial transcription factor A (mtTFA) may be a novel target for the treatment of pancreatic ductal adenocarcinoma (PDAC).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MtTFA antibody

 Reference Product  PubMed Publications
 NRF1 antibody  >105 publications with MtTFA and NRF1
 TFB2M antibody  >40 publications with MtTFA and TFB2M
 TFB1M antibody  >26 publications with MtTFA and TFB1M
 POLRMT antibody  >17 publications with MtTFA and POLRMT
 GABPA antibody  >12 publications with MtTFA and GABPA
 GABPB1 antibody  >1 publications with MtTFA and GABPB1
 TXN2 antibody  >1 publications with MtTFA and TXN2

Pathways associated with anti-MtTFA antibody

 Products by Pathway  Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Mitochondrial Gene Expression Pathway antibodies  Mitochondrial Gene Expression Pathway Diagram
 Mitochondrial Biogenesis Pathway antibodies  Mitochondrial Biogenesis Pathway Diagram
 Mitochondrial Transcription Initiation Pathway antibodies  Mitochondrial Transcription Initiation Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
 Transcription From Mitochondrial Promoters Pathway antibodies  Transcription From Mitochondrial Promoters Pathway Diagram

Diseases associated with anti-MtTFA antibody

 Disease Name  Pubmed Publications
 Mitochondrial Diseases Antibodies  >99 publications with MtTFA and Mitochondrial Diseases
 Nervous System Diseases Antibodies  >86 publications with MtTFA and Nervous System Diseases
 Disease Models, Animal Antibodies  >54 publications with MtTFA and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >49 publications with MtTFA and Cardiovascular Diseases
 Insulin Resistance Antibodies  >41 publications with MtTFA and Insulin Resistance
 Heart Diseases Antibodies  >34 publications with MtTFA and Heart Diseases
 Inflammation Antibodies  >31 publications with MtTFA and Inflammation
 Necrosis Antibodies  >27 publications with MtTFA and Necrosis
 Liver Diseases Antibodies  >19 publications with MtTFA and Liver Diseases
 Fatty Liver Antibodies  >16 publications with MtTFA and Fatty Liver

Organs/Tissues associated with anti-MtTFA antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >202 publications with MtTFA and Muscle
 Heart Antibodies  >84 publications with MtTFA and Heart
 Blood Antibodies  >76 publications with MtTFA and Blood
 Brain Antibodies  >75 publications with MtTFA and Brain
 Liver Antibodies  >73 publications with MtTFA and Liver
 Connective Tissue Antibodies  >30 publications with MtTFA and Connective Tissue
 Vascular Antibodies  >21 publications with MtTFA and Vascular
 Lung Antibodies  >17 publications with MtTFA and Lung
 Kidney Antibodies  >15 publications with MtTFA and Kidney
 Thyroid Antibodies  >15 publications with MtTFA and Thyroid
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