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AIM2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243073

MBS243073 is an antibody targeting AIM2. Also known as Goat Polyclonal to Human AIM2. Reactive in Gibbon, HumanPredicted Reactivity: Monkey (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Overview

Product Name
AIM2, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human AIM2
Product Gene Name
anti-AIM2 antibody
Product Synonym Names
Anti-AIM2 Antibody (C-Terminus) IHC-plus; AIM2; Absent in melanoma 2; PYHIN4; Human AIM2
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human AIM2.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
38,954 Da
OMIM
604578
3D Structure
ModBase 3D Structure for O14862
Target Species
Human
Immunogen Description
Synthetic peptide C-GEKLQLTSGVHSTIK from the C-terminus of human AIM2 (NP_004824.1). Percent identity by BLAST analysis: Human, Gibbon, Marmoset (100%); Monkey (93%).
Immunogen Type
Synthetic peptide
Immunogen
AIM2 antibody was raised against synthetic peptide C-GEKLQLTSGVHSTIK from the C-terminus of human AIM2 (NP_004824.1). Percent identity by BLAST analysis: Human, Gibbon, Marmoset (100%); Monkey (93%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-AIM2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-AIM2 antibody
ELISA (1:8000), IHC-P (3.75 ug/ml), WB (1 - 3 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:8000. Western blot: Preliminary experiments gave an approx. 80kDa band in Human Peripheral Blood Mononucleocytes lysates after 1 ug/ml antibody staining. Please note that currently we cannot find an...

Immunohistochemistry (IHC) of anti-AIM2 antibody

Anti-AIM2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-AIM2 Polyclonal Antibody – Cat# MBS243073

Western Blot (WB) of anti-AIM2 antibody

Antibody staining of IFNbeta-treated WI-38 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-AIM2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS243073

Other Notes

Small volumes of anti-AIM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AIM2. It may not necessarily be applicable to this product.

NCBI GI #
4757734
NCBI GeneID
9447
NCBI Accession #
NP_004824.1
UniProt Primary Accession #
O14862
UniProt Secondary Accession #
Q5T3V9; Q96FG9; A8K7M7
UniProt Related Accession #
O14862
GenBank Nucleotide #
NM_004833.1
NCBI Official Full Name
interferon-inducible protein AIM2
NCBI Official Synonym Full Names
absent in melanoma 2
NCBI Official Symbol
AIM2
NCBI Official Synonym Symbols
PYHIN4
UniProt Protein Name
Interferon-inducible protein AIM2
UniProt Synonym Protein Names
Absent in melanoma 2
Protein Family
Interferon-inducible protein
UniProt Gene Name
AIM2
UniProt Entry Name
AIM2_HUMAN
NCBI Protein Information
interferon-inducible protein AIM2

NCBI Summary for AIM2

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]

UniProt Comments for AIM2

AIM2: a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: identical protein binding; protein binding; double-stranded DNA binding

Biological Process: apoptosis; positive regulation of interleukin-1 beta secretion; activation of NF-kappaB transcription factor; positive regulation of protein oligomerization; positive regulation of interleukin-1 beta production; tumor necrosis factor-mediated signaling pathway; inhibition of NF-kappaB transcription factor; innate immune response; immune response; interleukin-1 beta secretion; positive regulation of defense response to virus by host; inflammatory response; activation of innate immune response
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Research Articles on AIM2

1. EB1 has a role in linking AIM2 inflammasomes with autophagy-dependent secretion

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AIM2 antibody

 Reference Product  PubMed Publications
 CASP1 antibody  >134 publications with AIM2 and CASP1
 NLRP3 antibody  >103 publications with AIM2 and NLRP3
 NLRC4 antibody  >49 publications with AIM2 and NLRC4
 NLRP1 antibody  >27 publications with AIM2 and NLRP1
 PYCARD antibody  >23 publications with AIM2 and PYCARD
 IFNG antibody  >2 publications with AIM2 and IFNG
 MEFV antibody  >1 publications with AIM2 and MEFV

Pathways associated with anti-AIM2 antibody

 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 NOD Pathway antibodies  NOD Pathway Diagram
 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies  Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
 The AIM2 Inflammasome Pathway antibodies  The AIM2 Inflammasome Pathway Diagram

Diseases associated with anti-AIM2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >92 publications with AIM2 and Inflammation
 Necrosis Antibodies  >12 publications with AIM2 and Necrosis
 Nervous System Diseases Antibodies  >9 publications with AIM2 and Nervous System Diseases
 Central Nervous System Diseases Antibodies  >9 publications with AIM2 and Central Nervous System Diseases
 Breast Neoplasms Antibodies  >4 publications with AIM2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with AIM2 and Neoplasms, Experimental
 Lymphoma, B-Cell Antibodies  >3 publications with AIM2 and Lymphoma, B-Cell
 Lymphoma Antibodies  >3 publications with AIM2 and Lymphoma
 Myocardial Ischemia Antibodies  >2 publications with AIM2 and Myocardial Ischemia
 Liver Cirrhosis Antibodies  >2 publications with AIM2 and Liver Cirrhosis

Organs/Tissues associated with anti-AIM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >33 publications with AIM2 and Blood
 Bone Antibodies  >16 publications with AIM2 and Bone
 Brain Antibodies  >11 publications with AIM2 and Brain
 Lung Antibodies  >10 publications with AIM2 and Lung
 Intestine Antibodies  >6 publications with AIM2 and Intestine
 Mouth Antibodies  >5 publications with AIM2 and Mouth
 Lymph Node Antibodies  >3 publications with AIM2 and Lymph Node
 Cervix Antibodies  >1 publications with AIM2 and Cervix
 Spleen Antibodies  >1 publications with AIM2 and Spleen
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