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WNT5B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243107

WNT signaling pathway plays key roles in carcinogenesis and embryogenesis, and WNT signaling molecules are potent targets for identification, prevention and treatment of cancer as well as for regenerative medicine or tissue engineering. More details

$630 / 0.05 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
WNT5B, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human WNT5B
Product Gene Name
anti-WNT5B antibody
Product Synonym Names
Anti-WNT5B Antibody (Internal) IHC-plus; WNT5B; Protein Wnt-5b; WNT-5B protein; Human WNT5B
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Human, Monkey, Orangutan
Predicted Reactivity: Gorilla, Dog, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human WNT5B. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except WNT5A (71%).
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
40,323 Da
OMIM
606361
3D Structure
ModBase 3D Structure for Q9H1J7
Target Species
Human
Immunogen Description
Synthetic 14 amino acid peptide from internal region of human WNT5B. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey, Marmoset (100%); Gorilla, Elephant, Panda, Dog, Horse, Rabbit, Pig, Opossum (93%); Mouse.
Immunogen Type
Synthetic peptide
Immunogen
WNT5B antibody was raised against synthetic 14 amino acid peptide from internal region of human WNT5B. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey, Marmoset (100%); Gorilla, Elephant, Panda, Dog, Horse, Rabbit, Pig, Opossum (93%); Mouse, Hamster, Bovine (86%).
Antigen Modification
Internal

Product Categories/Family for anti-WNT5B antibody

Family: WNT
Applications Tested/Suitable for anti-WNT5B antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-WNT5B antibody
IHC-P (2.5 ug/ml)

Immunohistochemistry (IHC) of anti-WNT5B antibody

Anti-WNT5B antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-WNT5B Polyclonal Antibody – Cat# MBS243107

Immunohistochemistry (IHC) of anti-WNT5B antibody

Anti-WNT5B antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-WNT5B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243107

Immunohistochemistry (IHC) of anti-WNT5B antibody

Anti-WNT5B antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-WNT5B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243107

Other Notes

Small volumes of anti-WNT5B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WNT5B purchase

MBS243107 is an antibody targeting WNT5B. Also known as Rabbit Polyclonal to Human WNT5B. Reactive in Gibbon, Human, Monkey, Orangutan
Predicted Reactivity: Gorilla, Dog, Horse, Pig, Rabbit (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for WNT5B. It may not necessarily be applicable to this product.

NCBI GI #
14249180
NCBI GeneID
81029
NCBI Accession #
NP_116031.1
UniProt Primary Accession #
Q9H1J7
UniProt Secondary Accession #
Q96S49; Q9BV04; A8K315; D3DUP9
UniProt Related Accession #
Q9H1J7
GenBank Nucleotide #
NM_032642.2
NCBI Official Full Name
protein Wnt-5b
NCBI Official Synonym Full Names
wingless-type MMTV integration site family, member 5B
NCBI Official Symbol
WNT5B
UniProt Protein Name
Protein Wnt-5b
UniProt Gene Name
WNT5B
UniProt Entry Name
WNT5B_HUMAN
NCBI Protein Information
protein Wnt-5b; WNT-5B protein

NCBI Summary for WNT5B

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
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UniProt Comments for WNT5B

WNT5B: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Interacts with PORCN. Belongs to the Wnt family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: extracellular space; proteinaceous extracellular matrix; cell surface; Golgi lumen; endoplasmic reticulum lumen; plasma membrane; extracellular region

Molecular Function: frizzled binding; receptor binding

Biological Process: fat cell differentiation; neuron differentiation; cell fate commitment; Wnt receptor signaling pathway; wound healing; chondrocyte differentiation; positive regulation of fat cell differentiation; positive regulation of cell migration
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Research Articles on WNT5B

1. This study shows that the WNT5B germline variant rs2010851 was significantly identified as a stage-dependent prognostic marker for CC patients after 5-fluorouracil-based adjuvant therapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-WNT5B antibody

 Reference Product  PubMed Publications
 FZD1 antibody  >10 publications with WNT5B and FZD1
 FZD6 antibody  >10 publications with WNT5B and FZD6
 FZD7 antibody  >10 publications with WNT5B and FZD7
 FZD4 antibody  >9 publications with WNT5B and FZD4
 FZD5 antibody  >8 publications with WNT5B and FZD5
 FZD10 antibody  >5 publications with WNT5B and FZD10
 SFRP2 antibody  >4 publications with WNT5B and SFRP2
 FZD8 antibody  >3 publications with WNT5B and FZD8
 SFRP5 antibody  >2 publications with WNT5B and SFRP5
 PORCN antibody  >1 publications with WNT5B and PORCN

Pathways associated with anti-WNT5B antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram

Diseases associated with anti-WNT5B antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with WNT5B and Inflammation
 Lung Neoplasms Antibodies  >5 publications with WNT5B and Lung Neoplasms
 Disease Models, Animal Antibodies  >5 publications with WNT5B and Disease Models, Animal
 Necrosis Antibodies  >4 publications with WNT5B and Necrosis
 Fibrosis Antibodies  >4 publications with WNT5B and Fibrosis
 Kidney Diseases Antibodies  >4 publications with WNT5B and Kidney Diseases
 Nervous System Diseases Antibodies  >4 publications with WNT5B and Nervous System Diseases
 Lung Diseases Antibodies  >3 publications with WNT5B and Lung Diseases
 Brain Diseases Antibodies  >3 publications with WNT5B and Brain Diseases
 Liver Diseases Antibodies  >2 publications with WNT5B and Liver Diseases

Organs/Tissues associated with anti-WNT5B antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >21 publications with WNT5B and Embryonic Tissue
 Bone Antibodies  >20 publications with WNT5B and Bone
 Muscle Antibodies  >14 publications with WNT5B and Muscle
 Brain Antibodies  >12 publications with WNT5B and Brain
 Lung Antibodies  >11 publications with WNT5B and Lung
 Kidney Antibodies  >10 publications with WNT5B and Kidney
 Liver Antibodies  >8 publications with WNT5B and Liver
 Eye Antibodies  >7 publications with WNT5B and Eye
 Heart Antibodies  >7 publications with WNT5B and Heart
 Intestine Antibodies  >6 publications with WNT5B and Intestine
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