Rabbit Anti-DGKZ Polyclonal Antibody – Cat# MBS243117

Anti-DGKZ antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.

DGKZ Antibody – Rabbit Polyclonal

Name: DGKZ Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS243117
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243117

MBS243117 is an antibody targeting DGKZ. Also known as Rabbit Polyclonal (IgG) to Human DGKZ. Reactive in Human. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

DGKZ, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal (IgG) to Human DGKZ

Product Gene Name

anti-DGKZ antibody

Product Synonym Names

Anti-DGKZ Antibody (aa601-650) IHC-plus; DGKZ; DAG kinase zeta; DAGK6; Diglyceride kinase zeta; Diacylglycerol kinase zeta; DGK-ZETA; Diacylglycerol kinase; zeta; HDGKzeta; DAGK5; Human DGKZ

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

DGKZ Antibody detects endogenous levels of total DGKZ protein.

Preparation and Storage

Store at -20 degree C for up to one year.

Molecular Weight

104,296 Da

OMIM

601441

3D Structure

ModBase 3D Structure for Q13574

Target Species

Human

Immunogen Description

Synthetic peptide from human DGKZ (aa601-650).

Immunogen

DGKZ antibody was raised against synthetic peptide from human DGKZ (aa601-650).

Antigen Modification

aa601-650

Product Categories/Family for anti-DGKZ antibody

Family: Non-Protein Kinase; Subfamily: Diacylglycerol kinase

Applications Tested/Suitable for anti-DGKZ antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-DGKZ antibody

ELISA (1:20000), IHC-P (5 ug/ml)

Other Notes

Small volumes of anti-DGKZ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DGKZ. It may not necessarily be applicable to this product.

NCBI GI #

41872507

NCBI GeneID

8525

NCBI Accession #

NP_003637.2

UniProt Primary Accession #

Q13574

UniProt Secondary Accession #

O00542; Q6ZVG7; Q8IVW9; B7Z2M9; B7Z6M3; E9PPW4; F6UCU9; G3V0F6; J3KNJ6

UniProt Related Accession #

Q13574

GenBank Nucleotide #

NM_003646.3

NCBI Official Full Name

diacylglycerol kinase zeta isoform 2

NCBI Official Synonym Full Names

diacylglycerol kinase, zeta

NCBI Official Symbol

DGKZ

NCBI Official Synonym Symbols

DAGK5; DAGK6; DGK-ZETA; hDGKzeta

UniProt Protein Name

Diacylglycerol kinase zeta

UniProt Synonym Protein Names

Diglyceride kinase zeta; DGK-zeta

Protein Family

Diacylglycerol kinase

UniProt Gene Name

DGKZ

UniProt Synonym Gene Names

DAGK6; DAG kinase zeta; DGK-zeta

UniProt Entry Name

DGKZ_HUMAN

NCBI Protein Information

diacylglycerol kinase zeta; DAG kinase zeta; diglyceride kinase zeta; diacylglycerol kinase, zeta 104kDa

NCBI Summary for DGKZ

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

UniProt Comments for DGKZ

DGKZ: Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity. Belongs to the eukaryotic diacylglycerol kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - glycerophospholipid; Lipid Metabolism - glycerolipid; EC 2.7.1.107; Motility/polarity/chemotaxis; Kinase, lipid

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: nucleoplasm; lamellipodium; cytoplasm; plasma membrane; nucleus

Molecular Function: enzyme inhibitor activity; protein C-terminus binding; lipid kinase activity; protein binding; metal ion binding; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity

Biological Process: G1 DNA damage checkpoint; platelet activation; cell migration; negative regulation of catalytic activity; protein kinase C activation; negative regulation of Ras protein signal transduction; negative regulation of mitotic cell cycle; blood coagulation; lipid phosphorylation; phosphorylation

Research Articles on DGKZ

1. Elevated DGKzeta expression contributes to increased Rho GTPase activation and the enhanced motility of metastatic cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DGKZ antibody

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Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerophospholipid Metabolism Pathway antibodies	Glycerophospholipid Metabolism Pathway Diagram
Glycerophospholipid Metabolism Pathway antibodies	Glycerophospholipid Metabolism Pathway Diagram

Diseases associated with anti-DGKZ antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1 publications with DGKZ and Nervous System Diseases
Genital Diseases, Male Antibodies	>1 publications with DGKZ and Genital Diseases, Male
Hyperplasia Antibodies	>1 publications with DGKZ and Hyperplasia

Organs/Tissues associated with anti-DGKZ antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with DGKZ and Brain
Prostate Antibodies	>1 publications with DGKZ and Prostate