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MC5R Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243169

MC5R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH), and activates adenylate cyclase. This receptor controls multiple functions in the brain and in peripheral tissues, such as… More details

$650 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MC5R / MC5 Receptor, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human MC5R / MC5 Receptor
Product Gene Name
Product Synonym Names
Anti-MC5R / MC5 Receptor Antibody (Internal) IHC-plus; MC5R; HMC5R; MC2; MC5-R; Melanocortin 5 receptor; MC5; MC5 receptor; MC-2; Melanocortin receptor 5; Melanocortin-5 receptor; Human MC5R; MC5 Receptor
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Chimpanzee, Gorilla, Human
Predicted Reactivity: Monkey, Mouse, Hamster (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human MC5 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
36,601 Da
OMIM
600042
3D Structure
ModBase 3D Structure for P33032
Target Species
Human
Immunogen Description
Synthetic 19 amino acid peptide from internal region of human MC5 Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Monkey (100%); Marmoset, Mouse, Hamster, Panda (95%); Rabbit (89%).
Immunogen Type
Synthetic peptide
Immunogen
MC5R / MC5 Receptor antibody was raised against synthetic 19 amino acid peptide from internal region of human MC5 Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Monkey (100%); Marmoset, Mouse, Hamster, Panda (95%); Rabbit (89%); Rat, Dog, Bat, Opossum (84%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-MC5R antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-MC5R antibody
IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubat...

Immunohistochemistry (IHC) of anti-MC5R antibody

Anti-MC5 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-MC5R Polyclonal Antibody – Cat# MBS243169

Other Notes

Small volumes of anti-MC5R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MC5R purchase

MBS243169 is an antibody targeting MC5R. Also known as Rabbit Polyclonal to Human MC5R / MC5 Receptor. Reactive in Chimpanzee, Gorilla, Human
Predicted Reactivity: Monkey, Mouse, Hamster (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MC5R. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
melanocortin receptor 5
NCBI Official Synonym Full Names
melanocortin 5 receptor
NCBI Official Symbol
MC5R
NCBI Official Synonym Symbols
MC2
UniProt Protein Name
Melanocortin receptor 5
UniProt Synonym Protein Names
MC-2
Protein Family
UniProt Gene Name
MC5R
UniProt Synonym Gene Names
MC5-R
UniProt Entry Name
MC5R_HUMAN
NCBI Protein Information
melanocortin receptor 5; melanocortin-5 receptor

NCBI Summary for MC5R

This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]
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UniProt Comments for MC5R

MC5R: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 18p11.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; melanocortin receptor activity; hormone binding

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of cAMP biosynthetic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-MC5R antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >40 publications with MC5R and Brain
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