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GPR65 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243189

GPR65 (TDAG8), a Lysophospholipid/Lysosphingolipid Receptor, is a molecular target for psychosine, a toxic lipid formed by the breakdown of galactosylceramide (cerebroside). A build-up of psychosine, caused by the lack of galactosylceramidase, results in the… More details

$630 / 0.05 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
GPR65 / TDAG8, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human GPR65 / TDAG8
Product Gene Name
Product Synonym Gene Name
TDAG8
Product Synonym Names
Anti-GPR65 / TDAG8 Antibody (Cytoplasmic Domain) IHC-plus; GPR65; G-protein coupled receptor 65; Gpcr25; HTDAG8; TDAG8; T-cell death-associated gene 8; Psychosine receptor; G protein-coupled receptor 65; Human GPR65; TDAG8
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gorilla, Human
Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human GPR65. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
39,333 Da
OMIM
604620
3D Structure
ModBase 3D Structure for Q8IYL9
Target Species
Human
Immunogen Description
Synthetic 19 amino acid peptide from 3rd cytoplasmic domain of human GPR65. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon, Marmoset (95%); Rabbit (84%).
Immunogen Type
Synthetic peptide
Immunogen
GPR65 / TDAG8 antibody was raised against synthetic 19 amino acid peptide from 3rd cytoplasmic domain of human GPR65. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon, Marmoset (95%); Rabbit (84%).
Antigen Modification
Cytoplasmic Domain
Applications Tested/Suitable for anti-GPR65 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-GPR65 antibody
IHC-P (9 - 23 ug/ml)

Immunohistochemistry (IHC) of anti-GPR65 antibody

Anti-GPR65 / TDAG8 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPR65 Polyclonal Antibody – Cat# MBS243189

Immunohistochemistry (IHC) of anti-GPR65 antibody

Anti-GPR65 / TDAG8 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPR65 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243189

Immunohistochemistry (IHC) of anti-GPR65 antibody

Anti-GPR65 antibody IHC of human lymph node, Hodgkin's disease. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPR65 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243189

Other Notes

Small volumes of anti-GPR65 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPR65 purchase

MBS243189 is an antibody targeting GPR65. Also known as Rabbit Polyclonal to Human GPR65 / TDAG8. Reactive in Gorilla, Human
Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GPR65. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
psychosine receptor
NCBI Official Synonym Full Names
G protein-coupled receptor 65
NCBI Official Symbol
GPR65
NCBI Official Synonym Symbols
TDAG8; hTDAG8
UniProt Protein Name
Psychosine receptor
UniProt Synonym Protein Names
G-protein coupled receptor 65; T-cell death-associated gene 8 protein
Protein Family
UniProt Gene Name
GPR65
UniProt Synonym Gene Names
TDAG8
UniProt Entry Name
PSYR_HUMAN
NCBI Protein Information
psychosine receptor; G-protein coupled receptor 65; T-cell death-associated gene 8 protein

UniProt Comments for GPR65

GPR65: Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation- induced cell death or differentiation of T-cells. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 14q31-q32.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; apoptosis; multicellular organismal development; positive regulation of cAMP biosynthetic process; positive regulation of stress fiber formation; actin cytoskeleton reorganization; immune response; response to acidity
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Research Articles on GPR65

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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