SOCS4 Antibody – Goat Polyclonal

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

SOCS4: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 14q22.1

Cellular Component: cytoplasm

Molecular Function: protein kinase inhibitor activity

Biological Process: negative regulation of epidermal growth factor receptor activity; regulation of growth; cytokine and chemokine mediated signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; negative regulation of JAK-STAT cascade