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HPC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243346

MBS243346 is an antibody targeting HPC2. Also known as Rabbit Polyclonal (IgG) to Human HPC2 / CBX4. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
HPC2 / CBX4, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human HPC2 / CBX4
Product Gene Name
anti-HPC2 antibody
Product Synonym Gene Name
CBX4
Product Synonym Names
Anti-HPC2 / CBX4 Antibody IHC-plus; CBX4; Chromobox homolog 4; Chromobox protein homolog 4; E3 SUMO-protein ligase CBX4; NBP16; NS5ATP1-binding protein 16; HPC2; Polycomb 2 homolog; PC2; Pc class 2 homolog; Human HPC2; CBX4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, pH 7.4, 0.05% sodium azide
Purity/Purification
Purified
Concentration
1 mg/ml (lot specific)
Specificity
Not tested with other proteins.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
31,987 Da
OMIM
603079
3D Structure
ModBase 3D Structure for O00257
Target Species
Human
Immunogen Description
Synthetic peptide
Immunogen Type
Synthetic peptide
Applications Tested/Suitable for anti-HPC2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-HPC2 antibody
ELISA (1:10000), IHC-P (5 ug/ml), WB (1:250)

Immunohistochemistry (IHC) of anti-HPC2 antibody

Anti-HPC2 / CBX4 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
Rabbit Anti-HPC2 Polyclonal Antibody – Cat# MBS243346

Western Blot (WB) of anti-HPC2 antibody

 
Rabbit Anti-HPC2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS243346

Other Notes

Small volumes of anti-HPC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HPC2. It may not necessarily be applicable to this product.

NCBI GI #
55770830
NCBI GeneID
8535
NCBI Accession #
NP_003646.2
UniProt Primary Accession #
O00257
UniProt Secondary Accession #
Q6TPI8; Q96C04; B1PJR7
UniProt Related Accession #
O00257
GenBank Nucleotide #
NM_003655.2
NCBI Official Full Name
E3 SUMO-protein ligase CBX4
NCBI Official Synonym Full Names
chromobox homolog 4
NCBI Official Symbol
CBX4
NCBI Official Synonym Symbols
PC2; NBP16
UniProt Protein Name
E3 SUMO-protein ligase CBX4
UniProt Synonym Protein Names
Chromobox protein homolog 4; Polycomb 2 homolog; Pc2; hPc2
Protein Family
Histone promoter control protein
UniProt Gene Name
CBX4
UniProt Synonym Gene Names
Pc2; hPc2
UniProt Entry Name
CBX4_HUMAN
NCBI Protein Information
E3 SUMO-protein ligase CBX4; Pc class 2 homolog; polycomb 2 homolog; NS5ATP1-binding protein 16; chromobox protein homolog 4; chromobox homolog 4 (Pc class homolog, Drosophila)

UniProt Comments for HPC2

CBX4: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; SUMO ligase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: nucleoplasm; nuclear speck; PcG protein complex; nucleus

Molecular Function: protein binding; enzyme binding; single-stranded RNA binding; SUMO binding; phosphoprotein binding; chromatin binding; transcription corepressor activity; methylated histone residue binding; ligase activity

Biological Process: protein sumoylation; transcription, DNA-dependent; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
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Research Articles on HPC2

1. The presence of CBX4-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HPC2 antibody

 Reference Product  PubMed Publications
 BMI1 antibody  >15 publications with HPC2 and BMI1
 RING1 antibody  >11 publications with HPC2 and RING1
 EZH2 antibody  >10 publications with HPC2 and EZH2
 CBX8 antibody  >8 publications with HPC2 and CBX8
 RNF2 antibody  >3 publications with HPC2 and RNF2
 PHC1 antibody  >2 publications with HPC2 and PHC1
 PHC2 antibody  >1 publications with HPC2 and PHC2
 PCGF2 antibody  >1 publications with HPC2 and PCGF2
 CTBP1 antibody  >1 publications with HPC2 and CTBP1

Pathways associated with anti-HPC2 antibody

 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Oxidative Stress Induced Senescence Pathway antibodies  Oxidative Stress Induced Senescence Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram

Diseases associated with anti-HPC2 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >4 publications with HPC2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with HPC2 and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with HPC2 and Liver Diseases
 Disease Models, Animal Antibodies  >2 publications with HPC2 and Disease Models, Animal
 Immune System Diseases Antibodies  >1 publications with HPC2 and Immune System Diseases
 Breast Neoplasms Antibodies  >1 publications with HPC2 and Breast Neoplasms
 Inflammation Antibodies  >1 publications with HPC2 and Inflammation

Organs/Tissues associated with anti-HPC2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with HPC2 and Blood
 Liver Antibodies  >3 publications with HPC2 and Liver
 Vascular Antibodies  >2 publications with HPC2 and Vascular
 Kidney Antibodies  >2 publications with HPC2 and Kidney
 Prostate Antibodies  >2 publications with HPC2 and Prostate
 Ovary Antibodies  >1 publications with HPC2 and Ovary
 Skin Antibodies  >1 publications with HPC2 and Skin
 Thymus Antibodies  >1 publications with HPC2 and Thymus
 Brain Antibodies  >1 publications with HPC2 and Brain
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