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DPR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243370

MBS243370 is an antibody targeting DPR2. Also known as Rabbit Polyclonal to Human DPR2 / DACT2. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DPR2 / DACT2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human DPR2 / DACT2
Product Gene Name
anti-DPR2 antibody
Product Synonym Gene Name
DACT2
Product Synonym Names
Anti-DPR2 / DACT2 Antibody (N-Terminus) IHC-plus; DACT2; BA503C24.7; DPR2; RP11-503C24.7; C6orf116; Dapper homolog 2; DAPPER2; Human DPR2; DACT2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS containing 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
At least two isoforms of Dact2 are known to exist.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
29,350 Da
OMIM
608966
3D Structure
ModBase 3D Structure for Q5SW24
Target Species
Human
Immunogen Description
A 12 amino acid peptide from near the amino terminus of human DACT2.
Immunogen Type
Synthetic peptide
Immunogen
DPR2 / DACT2 antibody was raised against a 12 amino acid peptide from near the amino terminus of human DACT2.
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-DPR2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-DPR2 antibody
ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml)

Immunohistochemistry (IHC) of anti-DPR2 antibody

Anti-DACT2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-DPR2 Polyclonal Antibody – Cat# MBS243370

Immunohistochemistry (IHC) of anti-DPR2 antibody

Anti-DACT2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-DPR2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243370

Immunofluorescence (IF) of anti-DPR2 antibody

Immunofluorescence of Dact2 in Human Brain cells with Dact2 antibody at 20 ug/ml.
Rabbit Anti-DPR2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS243370

Western Blot (WB) of anti-DPR2 antibody

Western blot of Dact2 in SK-N-SH cell lysate with Dact2 antibody at 1 ug/ml.
Rabbit Anti-DPR2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS243370

Other Notes

Small volumes of anti-DPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DPR2. It may not necessarily be applicable to this product.

NCBI GI #
163965434
NCBI GeneID
168002
NCBI Accession #
NP_999627.2
UniProt Primary Accession #
Q5SW24
UniProt Secondary Accession #
Q2NKJ2; Q569G0; Q8WYW2
UniProt Related Accession #
Q5SW24
GenBank Nucleotide #
NM_214462.4
NCBI Official Full Name
dapper homolog 2 isoform a
NCBI Official Synonym Full Names
dishevelled-binding antagonist of beta-catenin 2
NCBI Official Symbol
DACT2
NCBI Official Synonym Symbols
DPR2; DAPPER2; C6orf116; bA503C24.7
UniProt Protein Name
Dapper homolog 2
UniProt Synonym Protein Names
Dapper antagonist of catenin 2
UniProt Gene Name
DACT2
UniProt Synonym Gene Names
C6orf116
UniProt Entry Name
DACT2_HUMAN
NCBI Protein Information
dapper homolog 2; dapper antagonist of catenin 2; dapper homolog 2, antagonist of beta-catenin; dapper, antagonist of beta-catenin, homolog 2

UniProt Comments for DPR2

DACT2: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling. Belongs to the dapper family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: mitochondrion

Molecular Function: protein kinase C binding; protein kinase A binding; beta-catenin binding; transcription factor binding

Biological Process: skin development; hemopoietic progenitor cell differentiation; negative regulation of cell adhesion
Show more

Research Articles on DPR2

1. Loss of DACT2 expression is associated with esophageal squamous cell carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DPR2 antibody

 Reference Product  PubMed Publications
 PRICKLE2 antibody  >2 publications with DPR2 and PRICKLE2

Pathways associated with anti-DPR2 antibody

 Products by Pathway  Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with anti-DPR2 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >4 publications with DPR2 and Carcinoma, Hepatocellular
 Congenital Abnormalities Antibodies  >1 publications with DPR2 and Congenital Abnormalities
 Neoplasm Metastasis Antibodies  >1 publications with DPR2 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >1 publications with DPR2 and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with DPR2 and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with DPR2 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with DPR2 and Liver Diseases

Organs/Tissues associated with anti-DPR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >4 publications with DPR2 and Embryonic Tissue
 Eye Antibodies  >1 publications with DPR2 and Eye
 Placenta Antibodies  >1 publications with DPR2 and Placenta
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