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EFCAB4B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243373

MBS243373 is an antibody targeting EFCAB4B. Also known as Rabbit Polyclonal to Human EFCAB4B. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
EFCAB4B, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human EFCAB4B
Product Gene Name
anti-EFCAB4B antibody
Product Synonym Names
Anti-EFCAB4B Antibody (C-Terminus) IHC-plus; EFCAB4B; CRACR2A; CRAC channel regulator 2A; Human EFCAB4B
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human EFCAB4B
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
83,193 Da
OMIM
614178
3D Structure
ModBase 3D Structure for Q9BSW2
Target Species
Human
Immunogen Description
A 14 amino acid peptide near the carboxy terminus of human EFCAB4B.
Immunogen Type
Synthetic peptide
Immunogen
EFCAB4B antibody was raised against a 14 amino acid peptide near the carboxy terminus of human EFCAB4B.
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-EFCAB4B antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-EFCAB4B antibody
ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: EFCAB4B antibody can be used for detection of EFCAB4B by Western blot at 1-2 ug/ml.

Immunohistochemistry (IHC) of anti-EFCAB4B antibody

Anti-EFCAB4B antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-EFCAB4B Polyclonal Antibody – Cat# MBS243373

Immunohistochemistry (IHC) of anti-EFCAB4B antibody

Anti-EFCAB4B antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-EFCAB4B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243373

Immunofluorescence (IF) of anti-EFCAB4B antibody

Immunofluorescence of EFCAB4B in human kidney tissue with EFCAB4B antibody at 20 ug/ml.
Rabbit Anti-EFCAB4B Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS243373

Western Blot (WB) of anti-EFCAB4B antibody

Western blot analysis of EFCAB4B in mouse kidney tissue lysate with EFCAB4B antibody at 1 ug/ml.
Rabbit Anti-EFCAB4B Polyclonal Antibody, Western Blot (WB) – Cat# MBS243373

Other Notes

Small volumes of anti-EFCAB4B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EFCAB4B. It may not necessarily be applicable to this product.

NCBI GI #
14249254
NCBI GeneID
84766
NCBI Accession #
NP_116069.1
UniProt Primary Accession #
Q9BSW2
UniProt Secondary Accession #
B4E1X0; B9EK63
UniProt Related Accession #
Q9BSW2
GenBank Nucleotide #
NM_032680.3
NCBI Official Full Name
EF-hand calcium-binding domain-containing protein 4B isoform c
NCBI Official Synonym Full Names
calcium release activated channel regulator 2A
NCBI Official Symbol
CRACR2A
NCBI Official Synonym Symbols
EFCAB4B
UniProt Protein Name
EF-hand calcium-binding domain-containing protein 4B
UniProt Synonym Protein Names
Calcium release-activated calcium channel regulator 2A; CRAC channel regulator 2A; Calcium release-activated channel regulator 2A
UniProt Gene Name
CRACR2A
UniProt Synonym Gene Names
EFCAB4B; CRAC channel regulator 2A
UniProt Entry Name
EFC4B_HUMAN
NCBI Protein Information
EF-hand calcium-binding domain-containing protein 4B; CRAC regulator 2A; CRAC channel regulator 2A; EF-hand calcium binding domain 4B; calcium release-activated channel regulator 2A; calcium release-activated calcium channel regulator 2A; Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A

UniProt Comments for EFCAB4B

EFCAB4B: Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. Belongs to the EFCAB4 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 12p13.32

Cellular Component: Golgi apparatus; membrane; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; calcium ion binding

Biological Process: activation of store-operated calcium channel activity; immune system process; positive regulation of calcium ion transport
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Research Articles on EFCAB4B

1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EFCAB4B antibody

 Reference Product  PubMed Publications
 STIM1 antibody  >4 publications with EFCAB4B and STIM1
 ORAI1 antibody  >4 publications with EFCAB4B and ORAI1
 ORAI3 antibody  >1 publications with EFCAB4B and ORAI3

Diseases associated with anti-EFCAB4B antibody

 Disease Name  Pubmed Publications
  Antibodies  >6 publications with EFCAB4B and
 Death Antibodies  >2 publications with EFCAB4B and Death

Organs/Tissues associated with anti-EFCAB4B antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with EFCAB4B and Blood
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