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RORB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243374

Retinoid-related orphan receptor beta (ROR beta), a NR1 thyroid hormone receptor, affects the development and functioning of the central nervous system, including sensory input integration and circadian timing. Disruption of ROR beta in mice results in… More details

$630 / 0.05 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
RORB / ROR Beta, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human RORB / ROR Beta
Product Gene Name
anti-RORB antibody
Product Synonym Names
Anti-RORB / ROR Beta Antibody (Hinge Domain) IHC-plus; RORB; BA133M9.1; Nuclear receptor ROR-beta; NR1F2; ROR Beta; ROR-BETA; Rorbeta; RZR-BETA; Nuclear receptor RZR-beta; RAR-related orphan receptor B; RZRB; Human RORB; ROR Beta
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Predicted Reactivity: Gorilla, Gibbon, Monkey, Bat, Bovine, Dog, Horse, Rabbit, Sheep (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human ROR Beta. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
52,073 Da
OMIM
601972
3D Structure
ModBase 3D Structure for Q92753
Target Species
Human
Immunogen Description
Synthetic 15 amino acid peptide from hinge domain of human ROR Beta. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Sheep, Bovine, Dog, Bat, Panda, Horse, Rabbit, Opossum, Platypus (93%); Rat, Hamster.
Immunogen Type
Synthetic peptide
Immunogen
RORB / ROR Beta antibody was raised against synthetic 15 amino acid peptide from hinge domain of human ROR Beta. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Sheep, Bovine, Dog, Bat, Panda, Horse, Rabbit, Opossum, Platypus (93%); Rat, Hamster, Elephant (87%); Mouse, Pig, Chicken, Lizard (80%).
Antigen Modification
Hinge Domain

Product Categories/Family for anti-RORB antibody

Family: NHR; Subfamily: NR1 Thyroid hormone-like
Applications Tested/Suitable for anti-RORB antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-RORB antibody
ELISA, IHC-P (20 ug/ml)

Immunohistochemistry (IHC) of anti-RORB antibody

Anti-RORB / ROR Beta antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-RORB Polyclonal Antibody – Cat# MBS243374

Immunohistochemistry (IHC) of anti-RORB antibody

Anti-ROR Beta antibody IHC of human brain, thalamus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-RORB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243374

Immunohistochemistry (IHC) of anti-RORB antibody

Anti-RORB / ROR Beta antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-RORB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243374

Other Notes

Small volumes of anti-RORB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RORB purchase

MBS243374 is an antibody targeting RORB. Also known as Rabbit Polyclonal to Human RORB / ROR Beta. Reactive in Human
Predicted Reactivity: Gorilla, Gibbon, Monkey, Bat, Bovine, Dog, Horse, Rabbit, Sheep (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RORB. It may not necessarily be applicable to this product.

NCBI GI #
19743907
NCBI GeneID
6096
NCBI Accession #
NP_008845.2
UniProt Primary Accession #
Q92753
UniProt Secondary Accession #
Q8WX73
UniProt Related Accession #
Q92753
GenBank Nucleotide #
NM_006914.3
NCBI Official Full Name
nuclear receptor ROR-beta
NCBI Official Synonym Full Names
RAR-related orphan receptor B
NCBI Official Symbol
RORB
NCBI Official Synonym Symbols
RZRB; NR1F2; ROR-BETA; RZR-BETA; bA133M9.1
UniProt Protein Name
Nuclear receptor ROR-beta
UniProt Synonym Protein Names
Nuclear receptor RZR-beta; Nuclear receptor subfamily 1 group F member 2; Retinoid-related orphan receptor-beta
Protein Family
Nuclear receptor
UniProt Gene Name
RORB
UniProt Synonym Gene Names
NR1F2; RZRB
UniProt Entry Name
RORB_HUMAN
NCBI Protein Information
nuclear receptor ROR-beta; nuclear receptor RZR-beta; RAR-related orphan receptor beta; retinoic acid-binding receptor beta; retinoid-related orphan receptor beta; retinoid-related orphan receptor-beta; nuclear receptor subfamily 1 group F member 2

NCBI Summary for RORB

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]
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UniProt Comments for RORB

RORB: Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; retinal rod cell development; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; rhythmic process; regulation of circadian rhythm; eye photoreceptor cell development; retinal cone cell development; regulation of transcription, DNA-dependent; visual perception; retina development in camera-type eye; steroid hormone mediated signaling; gene expression; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent
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Research Articles on RORB

1. these data demonstrate that Rorbeta regulates known osteogenic pathways, and may represent a novel therapeutic target for age-associated bone loss.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RORB antibody

 Reference Product  PubMed Publications
 RORC antibody  >5 publications with RORB and RORC
 NR4A2 antibody  >3 publications with RORB and NR4A2
 NR1D1 antibody  >2 publications with RORB and NR1D1

Pathways associated with anti-RORB antibody

 Products by Pathway  Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram

Organs/Tissues associated with anti-RORB antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with RORB and Brain
 Eye Antibodies  >10 publications with RORB and Eye
 Embryonic Tissue Antibodies  >2 publications with RORB and Embryonic Tissue
 Kidney Antibodies  >1 publications with RORB and Kidney
 Lung Antibodies  >1 publications with RORB and Lung
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