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SS18 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243375

MBS243375 is an antibody targeting SS18. Also known as Rabbit Polyclonal (IgG) to Human SS18 / SYT. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SS18 / SYT, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human SS18 / SYT
Product Gene Name
anti-SS18 antibody
Product Synonym Gene Name
SYT
Product Synonym Names
Anti-SS18 / SYT Antibody (aa1-50) IHC-plus; SS18; SSXT; SYT; Protein SYT; Hd21; Protein SSXT; Human SS18; SYT
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Specificity
SSXT Antibody detects endogenous levels of total SSXT protein.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
42,216 Da
OMIM
600192
3D Structure
ModBase 3D Structure for Q15532
Target Species
Human
Immunogen Description
Synthetic peptide from human SSXT (aa1-50).
Immunogen
SS18 / SYT antibody was raised against synthetic peptide from human SSXT (aa1-50).
Antigen Modification
aa1-50
Applications Tested/Suitable for anti-SS18 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-SS18 antibody
ELISA (1:1000), IHC-P (5 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-SS18 antibody

Anti-SS18 / SYT antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
Rabbit Anti-SS18 Polyclonal Antibody – Cat# MBS243375

Western Blot (WB) of anti-SS18 antibody

Western blot of extracts from HepG2/Jurkat/COLO205 cells, using SSXT Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-SS18 Polyclonal Antibody, Western Blot (WB) – Cat# MBS243375

Other Notes

Small volumes of anti-SS18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SS18. It may not necessarily be applicable to this product.

NCBI GI #
56117844
NCBI GeneID
6760
NCBI Accession #
NP_005628.2
UniProt Primary Accession #
Q15532
UniProt Secondary Accession #
Q16404; Q4VAX1; Q9BXC6; B0YJ95
UniProt Related Accession #
Q15532
GenBank Nucleotide #
NM_005637.2
NCBI Official Full Name
protein SSXT isoform 2
NCBI Official Synonym Full Names
synovial sarcoma translocation, chromosome 18
NCBI Official Symbol
SS18
NCBI Official Synonym Symbols
SYT; SSXT
UniProt Protein Name
Protein SSXT
UniProt Synonym Protein Names
Protein SYT; Synovial sarcoma translocated to X chromosome protein
Protein Family
Protein
UniProt Gene Name
SS18
UniProt Synonym Gene Names
SSXT; SYT
UniProt Entry Name
SSXT_HUMAN
NCBI Protein Information
protein SSXT; synovial sarcoma, translocated to X chromosome; synovial sarcoma translocated to X chromosome protein

UniProt Comments for SS18

SS18: Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). Belongs to the SS18 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: cytoplasmic microtubule; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity

Biological Process: response to drug; transcription, DNA-dependent; cell morphogenesis; ephrin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; microtubule cytoskeleton organization and biogenesis
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Research Articles on SS18

1. SS18-SSX-induced Wnt/beta-catenin signaling appears to be of crucial biological importance in synovial sarcoma tumorigenesis and progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SS18 antibody

 Reference Product  PubMed Publications
 SSX1 antibody  >64 publications with SS18 and SSX1
 SSX4 antibody  >13 publications with SS18 and SSX4
 SMARCA4 antibody  >3 publications with SS18 and SMARCA4
 SMARCA2 antibody  >3 publications with SS18 and SMARCA2
 COAA antibody  >1 publications with SS18 and COAA

Pathways associated with anti-SS18 antibody

 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with anti-SS18 antibody

 Disease Name  Pubmed Publications
 Sarcoma, Synovial Antibodies  >129 publications with SS18 and Sarcoma, Synovial
 Neoplasm Metastasis Antibodies  >8 publications with SS18 and Neoplasm Metastasis
 Death Antibodies  >4 publications with SS18 and Death
 Kidney Diseases Antibodies  >4 publications with SS18 and Kidney Diseases
 Liver Diseases Antibodies  >3 publications with SS18 and Liver Diseases
 Embryo Loss Antibodies  >3 publications with SS18 and Embryo Loss
 Disease Models, Animal Antibodies  >2 publications with SS18 and Disease Models, Animal
 Brain Diseases Antibodies  >2 publications with SS18 and Brain Diseases
 Necrosis Antibodies  >2 publications with SS18 and Necrosis
 Congenital Abnormalities Antibodies  >1 publications with SS18 and Congenital Abnormalities

Organs/Tissues associated with anti-SS18 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >14 publications with SS18 and Lung
 Bone Antibodies  >8 publications with SS18 and Bone
 Nerve Antibodies  >8 publications with SS18 and Nerve
 Kidney Antibodies  >7 publications with SS18 and Kidney
 Muscle Antibodies  >6 publications with SS18 and Muscle
 Heart Antibodies  >5 publications with SS18 and Heart
 Thyroid Antibodies  >4 publications with SS18 and Thyroid
 Liver Antibodies  >4 publications with SS18 and Liver
 Vascular Antibodies  >4 publications with SS18 and Vascular
 Testis Antibodies  >3 publications with SS18 and Testis
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