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TMC8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243449

MBS243449 is an antibody targeting TMC8. Also known as Rabbit Polyclonal to Human TMC8 / EVER2. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TMC8 / EVER2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human TMC8 / EVER2
Product Gene Name
anti-TMC8 antibody
Product Synonym Gene Name
EVER2
Product Synonym Names
Anti-TMC8 / EVER2 Antibody (Internal) IHC-plus; TMC8; EVER2; EVIN2; Transmembrane channel-like 8; EV2; Human TMC8; EVER2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
56,132 Da
OMIM
phenotype 605829
3D Structure
ModBase 3D Structure for Q8IU68
Target Species
Human
Immunogen Description
14 amino acid peptide from near the center of human EVER2.
Immunogen
TMC8 / EVER2 antibody was raised against 14 amino acid peptide from near the center of human EVER2.
Antigen Modification
Internal
Applications Tested/Suitable for anti-TMC8 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-TMC8 antibody
IHC-P (5 ug/ml), WB (1 - 2 ug/ml)

Immunohistochemistry (IHC) of anti-TMC8 antibody

Anti-TMC8 / EVER2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-TMC8 Polyclonal Antibody – Cat# MBS243449

Immunohistochemistry (IHC) of anti-TMC8 antibody

Anti-TMC8 / EVER2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-TMC8 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243449

Immunofluorescence (IF) of anti-TMC8 antibody

Immunofluorescence of EVER2 in Human Brain cells with EVER2 antibody at 20 ug/ml.
Rabbit Anti-TMC8 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS243449

Western Blot (WB) of anti-TMC8 antibody

Western blot of EVER2 in Jurkat cell lysate with EVER2 antibody at (A) 1 and (B) 2 ug/ml.
Rabbit Anti-TMC8 Polyclonal Antibody, Western Blot (WB) – Cat# MBS243449

Other Notes

Small volumes of anti-TMC8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TMC8. It may not necessarily be applicable to this product.

NCBI GI #
23943900
NCBI GeneID
147138
NCBI Accession #
NP_689681.2
UniProt Primary Accession #
Q8IU68
UniProt Secondary Accession #
Q2YDC0; Q8IWU7; Q8N358; Q8NF04
UniProt Related Accession #
Q8IU68
GenBank Nucleotide #
NM_152468.4
NCBI Official Full Name
transmembrane channel-like protein 8
NCBI Official Synonym Full Names
transmembrane channel-like 8
NCBI Official Symbol
TMC8
NCBI Official Synonym Symbols
EV2; EVER2; EVIN2
UniProt Protein Name
Transmembrane channel-like protein 8
UniProt Synonym Protein Names
Epidermodysplasia verruciformis protein 2
Protein Family
Transmembrane channel-like protein
UniProt Gene Name
TMC8
UniProt Synonym Gene Names
EVER2; EVIN2
UniProt Entry Name
TMC8_HUMAN
NCBI Protein Information
transmembrane channel-like protein 8; epidermodysplasia verruciformis 2; epidermodysplasia verruciformis protein 2

NCBI Summary for TMC8

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
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UniProt Comments for TMC8

TMC8: an endoplasmic reticulum multipass membrane protein. Defects in TMC8 cause Lutz-Lewandowsky epidermodysplasia verruciformis [MIM:226400], a rare skin disease characterized by increased susceptibility to infection by papillomaviruses with an accompanying high risk of skin carcinoma. Three splice-variant isoforms of the human protein have been described.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum membrane; nuclear membrane; endoplasmic reticulum; cytoplasm; integral to membrane

Molecular Function: protein binding; receptor binding

Biological Process: negative regulation of protein oligomerization; zinc ion homeostasis; ion transport; regulation of cell growth; negative regulation of protein binding

Disease: Epidermodysplasia Verruciformis
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Research Articles on TMC8

1. Loss of the HPV-infection resistance EVER2 protein impairs NF-kappaB signaling pathways in keratinocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TMC8 antibody

 Reference Product  PubMed Publications
 TMC6 antibody  >28 publications with TMC8 and TMC6
 SLC30A1 antibody  >3 publications with TMC8 and SLC30A1

Diseases associated with anti-TMC8 antibody

 Disease Name  Pubmed Publications
 Epidermodysplasia Verruciformis Antibodies  >33 publications with TMC8 and Epidermodysplasia Verruciformis
 Carcinoma Antibodies  >15 publications with TMC8 and Carcinoma
 Skin Neoplasms Antibodies  >8 publications with TMC8 and Skin Neoplasms
 Immune System Diseases Antibodies  >3 publications with TMC8 and Immune System Diseases
 Necrosis Antibodies  >2 publications with TMC8 and Necrosis
 Nervous System Diseases Antibodies  >1 publications with TMC8 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >1 publications with TMC8 and Neoplasms, Experimental
 Melanoma Antibodies  >1 publications with TMC8 and Melanoma
 Neurologic Manifestations Antibodies  >1 publications with TMC8 and Neurologic Manifestations

Organs/Tissues associated with anti-TMC8 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >24 publications with TMC8 and Skin
 Blood Antibodies  >4 publications with TMC8 and Blood
 Eye Antibodies  >1 publications with TMC8 and Eye
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