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PNPLA3 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243505

MBS243505 is an antibody targeting PNPLA3. Also known as Goat Polyclonal to Human PNPLA3 / Adiponutrin. Reactive in Bat, Hamster, Human, Mouse, Rabbit, RatPredicted Reactivity: Gorilla, Gibbon, Monkey, Dog (at least 90% immunogen sequence identity). Host:… More details

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Product Overview

Product Name
PNPLA3 / Adiponutrin, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human PNPLA3 / Adiponutrin
Product Gene Name
anti-PNPLA3 antibody
Product Synonym Names
Anti-PNPLA3 / Adiponutrin Antibody (Internal) IHC-plus; PNPLA3; ADPN; Acylglycerol O-acyltransferase; C22orf20; Adiponutrin; IPLA2epsilon; DJ796I17.1; IPLA(2)epsilon; IPLA2-epsilon; Human PNPLA3; Adiponutrin
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Hamster, Human, Mouse, Rabbit, Rat
Predicted Reactivity: Gorilla, Gibbon, Monkey, Dog (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human PNPLA3. This antibody is raised against a peptide derived from the Mouse protein sequence and this peptide differs from Human only in position 2.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
52,485 Da
OMIM
gene 613282
3D Structure
ModBase 3D Structure for Q9NST1
Target Species
Human
Immunogen Description
Synthetic peptide EHDICPKVKSTN from an internal region of human PNPLA3 (NP_473429.2). Percent identity by BLAST analysis: Mouse, Rat, Hamster, Bat, Rabbit (100%); Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog (92%); Bovine, Opossum (83%).
Immunogen Type
Synthetic peptide
Immunogen
PNPLA3 / Adiponutrin antibody was raised against synthetic peptide EHDICPKVKSTN from an internal region of human PNPLA3 (NP_473429.2). Percent identity by BLAST analysis: Mouse, Rat, Hamster, Bat, Rabbit (100%); Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog (92%); Bovine, Opossum (83%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-PNPLA3 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-PNPLA3 antibody
ELISA (1:128000), IHC-P (3.75 ug/ml), WB (0.05 - 0.2 ug/ml)

Immunohistochemistry (IHC) of anti-PNPLA3 antibody

Anti-PNPLA3 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-PNPLA3 Polyclonal Antibody – Cat# MBS243505

Western Blot (WB) of anti-PNPLA3 antibody

Antibody (0.05 ug/ml) staining of mouse heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1hr. Detected by chemiluminescence.
Goat Anti-PNPLA3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS243505

Other Notes

Small volumes of anti-PNPLA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PNPLA3. It may not necessarily be applicable to this product.

NCBI GI #
17196626
NCBI GeneID
80339
NCBI Accession #
NP_079501.2
UniProt Primary Accession #
Q9NST1
UniProt Secondary Accession #
Q6P1A1; Q96CB4; B0QYI0; B2RCL3; B3KW00
UniProt Related Accession #
Q9NST1
GenBank Nucleotide #
NM_025225.2
NCBI Official Full Name
patatin-like phospholipase domain-containing protein 3
NCBI Official Synonym Full Names
patatin-like phospholipase domain containing 3
NCBI Official Symbol
PNPLA3
NCBI Official Synonym Symbols
ADPN; C22orf20; iPLA(2)epsilon
UniProt Protein Name
Patatin-like phospholipase domain-containing protein 3
UniProt Synonym Protein Names
Acylglycerol O-acyltransferase (EC:2.3.1.-); Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon
Protein Family
Patatin-like phospholipase domain-containing protein
UniProt Gene Name
PNPLA3
UniProt Synonym Gene Names
ADPN; C22orf20; iPLA2-epsilon
UniProt Entry Name
PLPL3_HUMAN
NCBI Protein Information
patatin-like phospholipase domain-containing protein 3; adiponutrin; iPLA2epsilon; iPLA2-epsilon; acylglycerol O-acyltransferase; calcium-independent phospholipase A2-epsilon

NCBI Summary for PNPLA3

The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]

UniProt Comments for PNPLA3

PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - glycerolipid; Transferase; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation; Phospholipase; Amino Acid Metabolism - tyrosine; Membrane protein, integral; EC 3.1.1.3; Amino Acid Metabolism - phenylalanine

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane

Molecular Function: phospholipase A2 activity; triacylglycerol lipase activity; mono-olein transacylation activity; diolein transacylation activity

Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; triacylglycerol catabolic process; triacylglycerol biosynthetic process
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Research Articles on PNPLA3

1. We show results that suggest a possible role of PNPLA3 polymorphism as a risk factor for carotid atherosclerosis in chronic hepatitis C.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PNPLA3 antibody

 Reference Product  PubMed Publications
 PNPLA2 antibody  >9 publications with PNPLA3 and PNPLA2
 LPL antibody  >1 publications with PNPLA3 and LPL
 DGAT2 antibody  >1 publications with PNPLA3 and DGAT2

Pathways associated with anti-PNPLA3 antibody

 Products by Pathway  Pathway Diagram
 Acyl Chain Remodeling Of DAG And TAG Pathway antibodies  Acyl Chain Remodeling Of DAG And TAG Pathway Diagram
 Acylglycerol Degradation Pathway antibodies  Acylglycerol Degradation Pathway Diagram
 Acylglycerol Degradation Pathway antibodies  Acylglycerol Degradation Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram

Diseases associated with anti-PNPLA3 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >191 publications with PNPLA3 and Fatty Liver
 Liver Diseases Antibodies  >176 publications with PNPLA3 and Liver Diseases
 Non-alcoholic Fatty Liver Disease Antibodies  >107 publications with PNPLA3 and Non-alcoholic Fatty Liver Disease
 Fibrosis Antibodies  >75 publications with PNPLA3 and Fibrosis
 Liver Cirrhosis Antibodies  >66 publications with PNPLA3 and Liver Cirrhosis
 Liver Cirrhosis, Alcoholic Antibodies  >43 publications with PNPLA3 and Liver Cirrhosis, Alcoholic
 Liver Diseases, Alcoholic Antibodies  >37 publications with PNPLA3 and Liver Diseases, Alcoholic
 Carcinoma, Hepatocellular Antibodies  >37 publications with PNPLA3 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >33 publications with PNPLA3 and Inflammation
 Liver Neoplasms Antibodies  >19 publications with PNPLA3 and Liver Neoplasms

Organs/Tissues associated with anti-PNPLA3 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >249 publications with PNPLA3 and Liver
 Blood Antibodies  >58 publications with PNPLA3 and Blood
 Muscle Antibodies  >3 publications with PNPLA3 and Muscle
 Kidney Antibodies  >2 publications with PNPLA3 and Kidney
 Pancreas Antibodies  >1 publications with PNPLA3 and Pancreas
 Embryonic Tissue Antibodies  >1 publications with PNPLA3 and Embryonic Tissue
 Intestine Antibodies  >1 publications with PNPLA3 and Intestine
 Skin Antibodies  >1 publications with PNPLA3 and Skin
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