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ESRP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243625

MBS243625 is an antibody targeting ESRP1. Also known as Rabbit Polyclonal to Human ESRP1 / RBM35A. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ESRP1 / RBM35A, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human ESRP1 / RBM35A
Product Gene Name
anti-ESRP1 antibody
Product Synonym Gene Name
RBM35A
Product Synonym Names
Anti-ESRP1 / RBM35A Antibody (N-Terminus) IHC-plus; ESRP1; RBM35A; RMB35A; RNA binding motif protein 35A; RNA-binding motif protein 35A; RNA-binding protein 35A; Human ESRP1; RBM35A
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human ESRP1 / RBM35A. RBM35A antibody is predicted to not cross-react with other RBM35/ESRP family members. At least five isoforms of RBM35A are known to exist; this antibody will detect all five.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
73,133 Da
OMIM
612959
3D Structure
ModBase 3D Structure for Q6NXG1
Target Species
Human
Immunogen Description
A 18 amino acid peptide near the amino terminus of human RBM35A
Immunogen Type
Synthetic peptide
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-ESRP1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-ESRP1 antibody
IHC-P (5 ug/ml), WB (1 - 2 ug/ml)

Immunohistochemistry (IHC) of anti-ESRP1 antibody

Anti-ESRP1 / RBM35A antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-ESRP1 Polyclonal Antibody – Cat# MBS243625

Immunofluorescence (IF) of anti-ESRP1 antibody

Immunofluorescence of RBM35A in human colon tissue cells with RBM35A antibody at 20 ug/ml.
Rabbit Anti-ESRP1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS243625

Western Blot (WB) of anti-ESRP1 antibody

Western blot analysis of RBM35A in rat colon tissue lysate with RBM35A antibody at 0.5 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-ESRP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS243625

Other Notes

Small volumes of anti-ESRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ESRP1. It may not necessarily be applicable to this product.

NCBI GI #
56790297
NCBI GeneID
54845
NCBI Accession #
NP_060167.2
UniProt Primary Accession #
Q6NXG1
UniProt Secondary Accession #
Q2M2B0; Q499G3; Q6PJ86; Q9NXL8; A6NHA8; A8MPX1; E9PB47
UniProt Related Accession #
Q6NXG1
GenBank Nucleotide #
NM_017697.3
NCBI Official Full Name
epithelial splicing regulatory protein 1 isoform 1
NCBI Official Synonym Full Names
epithelial splicing regulatory protein 1
NCBI Official Symbol
ESRP1
NCBI Official Synonym Symbols
RBM35A; RMB35A
UniProt Protein Name
Epithelial splicing regulatory protein 1
UniProt Synonym Protein Names
RNA-binding motif protein 35A; RNA-binding protein 35A
Protein Family
Epithelial splicing regulatory protein
UniProt Gene Name
ESRP1
UniProt Synonym Gene Names
RBM35A
UniProt Entry Name
ESRP1_HUMAN
NCBI Protein Information
epithelial splicing regulatory protein 1; RNA-binding protein 35A; RNA binding motif protein 35A; RNA-binding motif protein 35A

NCBI Summary for ESRP1

ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

UniProt Comments for ESRP1

RBM35A: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Belongs to the ESRP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: nucleus

Molecular Function: mRNA binding; nucleotide binding

Biological Process: regulation of RNA splicing; RNA splicing; mRNA processing
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Research Articles on ESRP1

1. ESRP1 and ESRP2 suppress cancer cell motility via different mechanisms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ESRP1 antibody

 Reference Product  PubMed Publications
 FGFR2 antibody  >9 publications with ESRP1 and FGFR2
 EPCAM antibody  >3 publications with ESRP1 and EPCAM
 CDH1 antibody  >3 publications with ESRP1 and CDH1
 GRHL2 antibody  >3 publications with ESRP1 and GRHL2
 ENAH antibody  >3 publications with ESRP1 and ENAH
 SPINT1 antibody  >2 publications with ESRP1 and SPINT1
 CTNND1 antibody  >2 publications with ESRP1 and CTNND1
 CLDN7 antibody  >1 publications with ESRP1 and CLDN7

Diseases associated with anti-ESRP1 antibody

 Disease Name  Pubmed Publications
 Melanoma Antibodies  >3 publications with ESRP1 and Melanoma
 Prostatic Neoplasms Antibodies  >2 publications with ESRP1 and Prostatic Neoplasms
 Brain Diseases Antibodies  >2 publications with ESRP1 and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with ESRP1 and Cell Transformation, Neoplastic
 Respiratory Tract Diseases Antibodies  >2 publications with ESRP1 and Respiratory Tract Diseases
 Gastrointestinal Diseases Antibodies  >1 publications with ESRP1 and Gastrointestinal Diseases
 Kidney Diseases Antibodies  >1 publications with ESRP1 and Kidney Diseases

Organs/Tissues associated with anti-ESRP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with ESRP1 and Lung
 Brain Antibodies  >3 publications with ESRP1 and Brain
 Prostate Antibodies  >3 publications with ESRP1 and Prostate
 Placenta Antibodies  >2 publications with ESRP1 and Placenta
 Embryonic Tissue Antibodies  >2 publications with ESRP1 and Embryonic Tissue
 Pituitary Gland Antibodies  >2 publications with ESRP1 and Pituitary Gland
 Kidney Antibodies  >1 publications with ESRP1 and Kidney
 Liver Antibodies  >1 publications with ESRP1 and Liver
 Uterus Antibodies  >1 publications with ESRP1 and Uterus
 Mammary Gland Antibodies  >1 publications with ESRP1 and Mammary Gland
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