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TLL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243666

TLL2 encodes a Metallopeptidase M12A type protease that is structurally similar to bone morphogenic protein 1 (BMP1) and Drosophila Tolloid (TLD). In vitro studies have identified pro-lysyl oxidase as a substrate for TLL-2 protein. Fetal TLL-2 is expressed in… More details

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Product Overview

Online Datasheet in PDF
Product Name
TLL2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human TLL2
Product Gene Name
Product Synonym Names
Anti-TLL2 Antibody (CUB 2 Domain) IHC-plus; TLL2; MTLL-2; KIAA0932; Tolloid-like 2; Tolloid-like protein 2; Human TLL2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bat, Gibbon, Dog, Human, Monkey, Pig, Rat
Predicted Reactivity: Gorilla, Hamster (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human TLL2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
113,557 Da
OMIM
606743
3D Structure
ModBase 3D Structure for Q9Y6L7
Target Species
Human
Immunogen Description
Synthetic 13 amino acid peptide from CUB 2 domain human TLL2. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Galago, Marmoset, Rat, Dog, Bat, Pig (100%); Gorilla, Hamster, Panda (92%); Mouse, Horse (85%).
Immunogen Type
Synthetic peptide
Immunogen
TLL2 antibody was raised against synthetic 13 amino acid peptide from CUB 2 domain human TLL2. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Galago, Marmoset, Rat, Dog, Bat, Pig (100%); Gorilla, Hamster, Panda (92%); Mouse, Horse (85%).
Antigen Modification
CUB 2 Domain
Applications Tested/Suitable for anti-TLL2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-TLL2 antibody
IHC-P (20 ug/ml)

Immunohistochemistry (IHC) of anti-TLL2 antibody

Anti-TLL2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-TLL2 Polyclonal Antibody – Cat# MBS243666

Other Notes

Small volumes of anti-TLL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLL2 purchase

MBS243666 is an antibody targeting TLL2. Also known as Rabbit Polyclonal to Human TLL2. Reactive in Bat, Gibbon, Dog, Human, Monkey, Pig, Rat
Predicted Reactivity: Gorilla, Hamster (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TLL2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tolloid-like protein 2
NCBI Official Synonym Full Names
tolloid-like 2
NCBI Official Symbol
TLL2
UniProt Protein Name
Tolloid-like protein 2
Protein Family
UniProt Gene Name
TLL2
UniProt Synonym Gene Names
KIAA0932
UniProt Entry Name
TLL2_HUMAN
NCBI Protein Information
tolloid-like protein 2

NCBI Summary for TLL2

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]

UniProt Comments for TLL2

TLL2: Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Belongs to the peptidase M12A family.

Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 10q23-q24

Cellular Component: extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; multicellular organismal development; proteolysis; cell differentiation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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