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FP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243690

The prostaglandin F2-alpha receptor is a member of the Prostanoid Receptor subfamily. Along with various other prostaglandin receptors, it mediates the effects of prostaglandin F(2-alpha) which include modulation of intraocular pressure, corpus luteum… More details

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Product Overview

Online Datasheet in PDF
Product Name
FP / PTGFR, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human FP / PTGFR
Product Gene Name
anti-FP antibody
Product Synonym Gene Name
PTGFR
Product Synonym Names
Anti-FP / PTGFR Antibody (Extracellular Domain) IHC-plus; PTGFR; PGF receptor; PGF2-alpha receptor; Prostaglandin F receptor (FP); FP; PGF2 alpha receptor; Prostaglandin F receptor; Prostanoid FP receptor; Human FP; PTGFR
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gorilla, Human
Predicted Reactivity: Gibbon, Monkey, Horse (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human PTGFR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
30,766 Da
OMIM
600563
3D Structure
ModBase 3D Structure for P43088
Target Species
Human
Immunogen Description
Synthetic 18 amino acid peptide from 1st extracellular domain of human PTGFR. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Horse (94%); Marmoset, Mouse, Rat, Elephant, Panda, Bat, Dog, Rabbit, Pig (89%).
Immunogen Type
Synthetic peptide
Immunogen
FP / PTGFR antibody was raised against synthetic 18 amino acid peptide from 1st extracellular domain of human PTGFR. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Horse (94%); Marmoset, Mouse, Rat, Elephant, Panda, Bat, Dog, Rabbit, Pig (89%); Turkey, Chicken, Platypus (83%).
Antigen Modification
Extracellular Domain

Product Categories/Family for anti-FP antibody

Family: GPCR; Subfamily: Prostanoid
Applications Tested/Suitable for anti-FP antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-FP antibody
IHC-P (20 ug/ml)

Immunohistochemistry (IHC) of anti-FP antibody

Anti-PTGFR antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-FP Polyclonal Antibody – Cat# MBS243690

Immunohistochemistry (IHC) of anti-FP antibody

Anti-FP / PTGFR antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-FP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243690

Immunohistochemistry (IHC) of anti-FP antibody

Anti-FP / PTGFR antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-FP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243690

Immunohistochemistry (IHC) of anti-FP antibody

Anti-FP / PTGFR antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-FP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243690

Other Notes

Small volumes of anti-FP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FP purchase

MBS243690 is an antibody targeting FP. Also known as Rabbit Polyclonal to Human FP / PTGFR. Reactive in Gorilla, Human
Predicted Reactivity: Gibbon, Monkey, Horse (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FP. It may not necessarily be applicable to this product.

NCBI GI #
4506261
NCBI GeneID
5737
NCBI Accession #
NP_000950.1
UniProt Primary Accession #
P43088
UniProt Secondary Accession #
Q2KHP3; Q6RYQ6; Q9P1X4; A8K9Y0
UniProt Related Accession #
P43088
GenBank Nucleotide #
NM_000959.3
NCBI Official Full Name
prostaglandin F2-alpha receptor isoform a
NCBI Official Synonym Full Names
prostaglandin F receptor (FP)
NCBI Official Symbol
PTGFR
NCBI Official Synonym Symbols
FP
UniProt Protein Name
Prostaglandin F2-alpha receptor
UniProt Synonym Protein Names
Prostanoid FP receptor
Protein Family
FP protein
UniProt Gene Name
PTGFR
UniProt Synonym Gene Names
PGF receptor; PGF2-alpha receptor
UniProt Entry Name
PF2R_HUMAN
NCBI Protein Information
prostaglandin F2-alpha receptor; PGF receptor; PGF2 alpha receptor; PGF2-alpha receptor; prostanoid FP receptor; prostaglandin F2 alpha receptor; prostaglandin receptor (2-alpha)

NCBI Summary for FP

The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for FP

PTGFR: Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 1p31.1

Cellular Component: integral to plasma membrane; cytoplasm; extracellular region; plasma membrane

Molecular Function: prostaglandin F receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of cell proliferation; response to lipopolysaccharide; parturition; negative regulation of apoptosis
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Research Articles on FP

1. An association was found between SNPs of the FP receptor gene and the response to latanoprost in patients with glaucoma or OH.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FP antibody

 Reference Product  PubMed Publications
 PTGER1 antibody  >6 publications with FP and PTGER1
 OXTR antibody  >2 publications with FP and OXTR

Pathways associated with anti-FP antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Eicosanoid Ligand-binding Receptors Pathway antibodies  Eicosanoid Ligand-binding Receptors Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-FP antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with FP and Inflammation
 Metaplasia Antibodies  >1 publications with FP and Metaplasia
 Carcinoma Antibodies  >1 publications with FP and Carcinoma
 Breast Neoplasms Antibodies  >1 publications with FP and Breast Neoplasms
 Premature Birth Antibodies  >1 publications with FP and Premature Birth
 Prostatic Diseases Antibodies  >1 publications with FP and Prostatic Diseases
 Hypertension Antibodies  >1 publications with FP and Hypertension
 Pain Antibodies  >1 publications with FP and Pain
 Kidney Diseases Antibodies  >1 publications with FP and Kidney Diseases
 Necrosis Antibodies  >1 publications with FP and Necrosis

Organs/Tissues associated with anti-FP antibody

 Organ/Tissue Name  Pubmed Publications
 Uterus Antibodies  >12 publications with FP and Uterus
 Muscle Antibodies  >5 publications with FP and Muscle
 Placenta Antibodies  >4 publications with FP and Placenta
 Skin Antibodies  >1 publications with FP and Skin
 Prostate Antibodies  >1 publications with FP and Prostate
 Liver Antibodies  >1 publications with FP and Liver
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