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USP28 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243709

MBS243709 is an antibody targeting USP28. Also known as Goat Polyclonal to Human USP28. Reactive in Gibbon, Bovine, Dog, Horse, Human, Monkey, Pig, RabbitPredicted Reactivity: Bat (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
USP28, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human USP28
Product Gene Name
Product Synonym Names
Anti-USP28 Antibody (Internal) IHC-plus; USP28; Deubiquitinating enzyme 28; KIAA1515; Ubiquitin specific protease 28; Ubiquitin thioesterase 28; Ubiquitin thiolesterase 28; Human USP28
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Bovine, Dog, Horse, Human, Monkey, Pig, Rabbit
Predicted Reactivity: Bat (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human USP28.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
66,243 Da
OMIM
610748
3D Structure
ModBase 3D Structure for Q96RU2
Target Species
Human
Immunogen Description
Synthetic peptide C-SVELKHYIQEDN from an internal region of human USP28 (NP_065937.1). Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Panda, Bovine, Dog, Horse, Rabbit, Pig, Opossum (100%); Elephant, Bat (92%).
Immunogen Type
Synthetic peptide
Immunogen
USP28 antibody was raised against synthetic peptide C-SVELKHYIQEDN from an internal region of human USP28 (NP_065937.1). Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Panda, Bovine, Dog, Horse, Rabbit, Pig, Opossum (100%); Elephant, Bat (92%); Mouse, Rat, Hamster (83%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-USP28 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-USP28 antibody
ELISA (1:64000), IHC-P (2.5 - 3.75 ug/ml)

Immunohistochemistry (IHC) of anti-USP28 antibody

Anti-USP28 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Goat Anti-USP28 Polyclonal Antibody – Cat# MBS243709

Immunohistochemistry (IHC) of anti-USP28 antibody

Anti-USP28 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Goat Anti-USP28 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243709

Other Notes

Small volumes of anti-USP28 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for USP28. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase 28 isoform 1
NCBI Official Synonym Full Names
ubiquitin specific peptidase 28
NCBI Official Symbol
USP28
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 28
UniProt Synonym Protein Names
Deubiquitinating enzyme 28; Ubiquitin thioesterase 28; Ubiquitin-specific-processing protease 28
UniProt Gene Name
USP28
UniProt Synonym Gene Names
KIAA1515
UniProt Entry Name
UBP28_HUMAN
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 28; ubiquitin thioesterase 28; deubiquitinating enzyme 28; ubiquitin thiolesterase 28; ubiquitin specific protease 28; ubiquitin-specific-processing protease 28; ubiquitin carboxyl-terminal hydrolase 28 variant 1

NCBI Summary for USP28

The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).[supplied by OMIM, Mar 2008]
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UniProt Comments for USP28

USP28: a peptidase of the C19 family. USP28 and FBXW7 regulate Myc protein stability in response to DNA damage. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin-specific protease; Protease; EC 3.4.19.12

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus

Molecular Function: protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: cell proliferation; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; DNA damage checkpoint; response to ionizing radiation; DNA repair; response to DNA damage stimulus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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