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BEST2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243726

MBS243726 is an antibody targeting BEST2. Also known as Rabbit Polyclonal to Human BEST2 / Bestrophin-2. Reactive in Dog, Gorilla, Human, MonkeyPredicted Reactivity: Mouse, Bovine, Hamster (at least 90% immunogen sequence identity). Host: Rabbit. VMD2L1, a… More details

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Product Overview

Online Datasheet in PDF
Product Name
BEST2 / Bestrophin-2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human BEST2 / Bestrophin-2
Product Gene Name
Product Synonym Names
Anti-BEST2 / Bestrophin-2 Antibody (Internal) IHC-plus; BEST2; Bestrophin-2; Bestrophin 2; Hbest2; VMD2-like gene 1; VMD2L1; Human BEST2; Bestrophin-2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Dog, Gorilla, Human, Monkey
Predicted Reactivity: Mouse, Bovine, Hamster (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
0.9 mg/ml (lot specific)
Specificity
Human BEST2 / Bestrophin-2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except BEST1 (47%).
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
57,139 Da
OMIM
607335
3D Structure
ModBase 3D Structure for Q8NFU1
Target Species
Human
Immunogen Description
Synthetic 15 amino acid peptide from internal region of human BEST2 / Bestrophin-2. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Dog (100%); Mouse, Hamster, Panda, Bovine (93%); Opossum (87%); Elephant, Pig.
Immunogen Type
Synthetic peptide
Immunogen
BEST2 / Bestrophin-2 antibody was raised against synthetic 15 amino acid peptide from internal region of human BEST2 / Bestrophin-2. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Dog (100%); Mouse, Hamster, Panda, Bovine (93%); Opossum (87%); Elephant, Pig (80%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-BEST2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-BEST2 antibody
IHC-P (2.5 - 5 ug/ml)

Immunohistochemistry (IHC) of anti-BEST2 antibody

Anti-BEST2 / Bestrophin-2 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-BEST2 Polyclonal Antibody – Cat# MBS243726

Immunohistochemistry (IHC) of anti-BEST2 antibody

Anti-BEST2 / Bestrophin-2 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-BEST2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243726

Immunohistochemistry (IHC) of anti-BEST2 antibody

Anti-BEST2 / Bestrophin-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-BEST2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243726

Other Notes

Small volumes of anti-BEST2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BEST2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
bestrophin-2
NCBI Official Synonym Full Names
bestrophin 2
NCBI Official Symbol
BEST2
NCBI Official Synonym Symbols
VMD2L1
UniProt Protein Name
Bestrophin-2
UniProt Synonym Protein Names
Vitelliform macular dystrophy 2-like protein 1
Protein Family
UniProt Gene Name
BEST2
UniProt Synonym Gene Names
VMD2L1
UniProt Entry Name
BEST2_HUMAN
NCBI Protein Information
bestrophin-2; VMD2-like gene 1; vitelliform macular dystrophy 2-like 1; vitelliform macular dystrophy 2-like protein 1

NCBI Summary for BEST2

This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008]
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UniProt Comments for BEST2

BEST2: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Belongs to the bestrophin family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel; Transporter

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: plasma membrane; cilium

Molecular Function: chloride channel activity

Biological Process: membrane depolarization; sensory perception of smell
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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