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NANOS3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243792

MBS243792 is an antibody targeting NANOS3. Also known as Rabbit Polyclonal to Human NANOS3 / NOS-3. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Overview

Product Name
NANOS3 / NOS-3, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human NANOS3 / NOS-3
Product Gene Name
anti-NANOS3 antibody
Product Synonym Gene Name
NOS-3
Product Synonym Names
Anti-NANOS3 / NOS-3 Antibody (C-Terminus) IHC-plus; NANOS3; NANOS1L; Nanos homolog 3; Nanos homolog 3 (Drosophila); NOS-3; Human NANOS3; NOS-3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
20,728 Da
OMIM
608229
3D Structure
ModBase 3D Structure for P60323
Target Species
Human
Immunogen Description
16 amino acid peptide near the carboxy terminus of the human Nanos3.
Immunogen
NANOS3 / NOS-3 antibody was raised against 16 amino acid peptide near the carboxy terminus of the human Nanos3.
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-NANOS3 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-NANOS3 antibody
IHC-P (5 ug/ml), WB (1 - 2 ug/ml)

Immunohistochemistry (IHC) of anti-NANOS3 antibody

Anti-NANOS3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-NANOS3 Polyclonal Antibody – Cat# MBS243792

Immunofluorescence (IF) of anti-NANOS3 antibody

Immunofluorescence of Nanos3 in Human Brain cells with Nanos3 antibody at 20 ug/ml.
Rabbit Anti-NANOS3 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS243792

Western Blot (WB) of anti-NANOS3 antibody

Western blot of Nanos3 in human brain tissue lysate with Nanos3 antibody at 2 ug/ml.
Rabbit Anti-NANOS3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS243792

Other Notes

Small volumes of anti-NANOS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NANOS3. It may not necessarily be applicable to this product.

NCBI GI #
148886760
NCBI GeneID
342977
NCBI Accession #
NP_001092092.1
UniProt Primary Accession #
P60323
UniProt Secondary Accession #
Q495E5
UniProt Related Accession #
P60323
GenBank Nucleotide #
NM_001098622.2
NCBI Official Full Name
nanos homolog 3
NCBI Official Synonym Full Names
nanos homolog 3 (Drosophila)
NCBI Official Symbol
NANOS3
NCBI Official Synonym Symbols
NOS3; NANOS1L
UniProt Protein Name
Nanos homolog 3
Protein Family
Nanos
UniProt Gene Name
NANOS3
UniProt Synonym Gene Names
NOS3; NOS-3
UniProt Entry Name
NANO3_HUMAN
NCBI Protein Information
nanos homolog 3

UniProt Comments for NANOS3

NANOS3: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. Belongs to the nanos family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Cell development/differentiation

Chromosomal Location of Human Ortholog: 19p13.13

Cellular Component: stress granule; perinuclear region of cytoplasm; cytoplasm; nucleus

Molecular Function: protein binding; zinc ion binding; RNA binding

Biological Process: oogenesis; regulation of translation; regulation of cell cycle; negative regulation of translation; multicellular organismal development; spermatogenesis; germ cell development
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Research Articles on NANOS3

1. NANOS3 mutation is one possible cause of primary ovarian insufficiency.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NANOS3 antibody

 Reference Product  PubMed Publications
 DAZL antibody  >4 publications with NANOS3 and DAZL
 STRA8 antibody  >2 publications with NANOS3 and STRA8
 DND1 antibody  >2 publications with NANOS3 and DND1
 PUM2 antibody  >1 publications with NANOS3 and PUM2
 BMP8B antibody  >1 publications with NANOS3 and BMP8B
 TDRD1 antibody  >1 publications with NANOS3 and TDRD1
 PRDM14 antibody  >1 publications with NANOS3 and PRDM14

Diseases associated with anti-NANOS3 antibody

 Disease Name  Pubmed Publications
 Embryo Loss Antibodies  >3 publications with NANOS3 and Embryo Loss
 Infertility, Female Antibodies  >2 publications with NANOS3 and Infertility, Female
 Disease Models, Animal Antibodies  >1 publications with NANOS3 and Disease Models, Animal

Organs/Tissues associated with anti-NANOS3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with NANOS3 and Brain
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