Rabbit Anti-MLNR Polyclonal Antibody – Cat# MBS243843

Anti-MLNR antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

MLNR Antibody – Rabbit Polyclonal

Name: MLNR Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS243843
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243843

GPR38, also called Motilin Receptor, mediates smooth muscle contraction and controls gastrointestinal motility by binding motilin. The antibiotic erythromycin-A also induces smooth muscle contraction when binding to the motilin receptor. Two variants are… More details

$650 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MLNR/GPR38/Motilin Receptor, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human MLNR/GPR38/Motilin Receptor

Product Gene Name

anti-MLNR antibody

Product Synonym Names

Anti-MLNR/GPR38/Motilin Receptor Antibody (Cytoplasmic Domain) IHC-plus; MLNR; G-protein coupled receptor 38; Motilin receptor; MTLR; MTLR1; G protein-coupled receptor 38; GPR38; Human MLNR/GPR38/Motilin Receptor

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Gorilla, Human
Predicted Reactivity: Gibbon, Monkey, Bat (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human MLNR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

42,026 Da

OMIM

602885

3D Structure

ModBase 3D Structure for O43193

Target Species

Human

Immunogen Description

Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human MLNR. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey (95%); Gibbon, Marmoset, Bat (90%); Dog, Panda (85%); Bovine (80%).

Immunogen Type

Synthetic peptide

Immunogen

MLNR/GPR38/Motilin Receptor antibody was raised against synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human MLNR. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey (95%); Gibbon, Marmoset, Bat (90%); Dog, Panda (85%); Bovine (80%).

Antigen Modification

Cytoplasmic Domain

Product Categories/Family for anti-MLNR antibody

Family: GPCR; Subfamily: Motilin

Applications Tested/Suitable for anti-MLNR antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-MLNR antibody

IHC-P (1.1 ug/ml)

Other Notes

Small volumes of anti-MLNR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MLNR purchase

MBS243843 is an antibody targeting MLNR. Also known as Rabbit Polyclonal to Human MLNR/GPR38/Motilin Receptor. Reactive in Gorilla, Human
Predicted Reactivity: Gibbon, Monkey, Bat (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MLNR. It may not necessarily be applicable to this product.

NCBI GI #

4504095

NCBI GeneID

2862

NCBI Accession #

NP_001498.1

UniProt Primary Accession #

O43193

UniProt Related Accession #

O43193

GenBank Nucleotide #

NM_001507.1

NCBI Official Full Name

motilin receptor

NCBI Official Synonym Full Names

motilin receptor

NCBI Official Symbol

MLNR

NCBI Official Synonym Symbols

GPR38; MTLR1

UniProt Protein Name

Motilin receptor

UniProt Synonym Protein Names

G-protein coupled receptor 38

Protein Family

Motilin receptor

UniProt Gene Name

MLNR

UniProt Synonym Gene Names

GPR38; MTLR; MTLR1

UniProt Entry Name

MTLR_HUMAN

NCBI Protein Information

motilin receptor; G protein-coupled receptor 38

NCBI Summary for MLNR

Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]

UniProt Comments for MLNR

MLNR: Receptor for motilin. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q14-q21

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; growth hormone-releasing hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; digestion

Research Articles on MLNR

1. data support important roles of new regions in the TM domains of the motilin receptor for erythromycin action, suggesting differential mechanisms of actions by peptidyl and non-peptidyl ligands

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MLNR antibody

Reference Product	PubMed Publications
MLN antibody	>3 publications with MLNR and MLN

Pathways associated with anti-MLNR antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-MLNR antibody

Disease Name	Pubmed Publications
Cholecystitis Antibodies	>1 publications with MLNR and Cholecystitis