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CLTA Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243855

MBS243855 is an antibody targeting CLTA. Also known as Goat Polyclonal to Human CLTA / CLTB. Reactive in Bat, Gibbon, Bovine, Chicken, Dog, Xenopus, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Zebrafish. Host: Goat. More details

$680 / 0.05 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CLTA / CLTB, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human CLTA / CLTB
Product Gene Name
anti-CLTA antibody
Product Synonym Gene Name
CLTB
Product Synonym Names
Anti-CLTA / CLTB Antibody (Internal) IHC-plus; CLTA/CLTB; Human CLTA; CLTB
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Gibbon, Bovine, Chicken, Dog, Xenopus, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Zebrafish
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human CLTA. This antibody is expected to recognize all reported isoforms of light chains a and b.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
17,687 Da
OMIM
118960
Target Species
Human
Immunogen Description
Synthetic peptide CDFNPKSSKQAKD from an internal region of human CLTA (NP_001824.1; NP_009027.1; NP_001070145.1; NP_001825.1; NP_009028.1).
Immunogen Type
Synthetic peptide
Immunogen
CLTA / CLTB antibody was raised against synthetic peptide CDFNPKSSKQAKD from an internal region of human CLTA (NP_001824.1; NP_009027.1; NP_001070145.1; NP_001825.1; NP_009028.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Platypus, Xenopus, Salmon, Stickleback, Pufferfish, Zebrafish (100%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-CLTA antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CLTA antibody
ELISA (1:32000, 0.1 - 0.3 ug/ml), IHC-P (2.5 - 3.75 ug/ml), WB (0.1 - 0.3 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:32000. Western Blot: Approx. 35kD and 22-23kD bands observed in Human Brain (Frontal Cortex) lysates (calculated MW of 23.2kD according to NP_001825.1). The observed molecular weight of ~35kD corresp...

Immunohistochemistry (IHC) of anti-CLTA antibody

Anti-CLTA/CLTB antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Goat Anti-CLTA Polyclonal Antibody – Cat# MBS243855

Western Blot (WB) of anti-CLTA antibody

Antibody (0.1 ug/ml) staining of Human Frontal Cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-CLTA Polyclonal Antibody, Western Blot (WB) – Cat# MBS243855

Other Notes

Small volumes of anti-CLTA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CLTA. It may not necessarily be applicable to this product.

NCBI GI #
296179386
NCBI GeneID
1211
NCBI Accession #
NP_001171690.1
UniProt Secondary Accession #
Q2XPN5; Q53XZ1; A8K4W3; B4DIN1; F5H6N3
UniProt Related Accession #
P09496
GenBank Nucleotide #
NM_001184761.1
NCBI Official Full Name
clathrin light chain A isoform e
NCBI Official Synonym Full Names
clathrin, light chain A
NCBI Official Symbol
CLTA
NCBI Official Synonym Symbols
LCA
UniProt Protein Name
Clathrin light chain A
Protein Family
Clathrin
UniProt Gene Name
CLTA
UniProt Synonym Gene Names
Lca
UniProt Entry Name
CLCA_HUMAN
NCBI Protein Information
clathrin light chain A; clathrin, light polypeptide (Lca)

NCBI Summary for CLTA

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]
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UniProt Comments for CLTA

CLTA: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Belongs to the clathrin light chain family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Vesicle

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: clathrin coat of trans-Golgi network vesicle; clathrin coat; intracellular membrane-bound organelle; membrane; cytoplasmic membrane-bound vesicle; plasma membrane; trans-Golgi network membrane; cytosol; clathrin coat of coated pit

Molecular Function: protein binding; clathrin heavy chain binding; structural molecule activity; peptide binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; axon guidance; intracellular protein transport; nerve growth factor receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; endocytosis; post-Golgi vesicle-mediated transport
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Research Articles on CLTA

1. Upon receptor activation, prostate alpha1A-adrenoceptors bind clathrin LCA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLTA antibody

 Reference Product  PubMed Publications
 CD4 antibody  >7 publications with CLTA and CD4
 CLTB antibody  >5 publications with CLTA and CLTB
 CLTC antibody  >3 publications with CLTA and CLTC

Pathways associated with anti-CLTA antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Arf1 Pathway antibodies  Arf1 Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram

Diseases associated with anti-CLTA antibody

 Disease Name  Pubmed Publications
 Skin Neoplasms Antibodies  >2 publications with CLTA and Skin Neoplasms
 Heart Diseases Antibodies  >2 publications with CLTA and Heart Diseases
 Nervous System Diseases Antibodies  >1 publications with CLTA and Nervous System Diseases

Organs/Tissues associated with anti-CLTA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with CLTA and Blood
 Heart Antibodies  >2 publications with CLTA and Heart
 Lung Antibodies  >2 publications with CLTA and Lung
 Skin Antibodies  >2 publications with CLTA and Skin
 Spleen Antibodies  >1 publications with CLTA and Spleen
 Muscle Antibodies  >1 publications with CLTA and Muscle
 Bone Antibodies  >1 publications with CLTA and Bone
 Lymph Node Antibodies  >1 publications with CLTA and Lymph Node
 Lymph Antibodies  >1 publications with CLTA and Lymph
 Umbilical Cord Antibodies  >1 publications with CLTA and Umbilical Cord
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