MGST1 Antibody – Rabbit Polyclonal

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

MGST1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity. Belongs to the MAPEG family.

Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 2.5.1.18; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase; Membrane protein, multi-pass; Mitochondrial; Other Amino Acids Metabolism - glutathione; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p12.3-p12.1

Cellular Component: peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; mitochondrion; apical part of cell; endoplasmic reticulum; mitochondrial inner membrane; integral to membrane; nucleus

Molecular Function: protein binding; protein homodimerization activity; glutathione binding; glutathione transferase activity; glutathione peroxidase activity

Biological Process: response to drug; Leydig cell differentiation; glutathione metabolic process; xenobiotic metabolic process; response to lipopolysaccharide; response to organic nitrogen