• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

PHAP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243932

Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
PHAP1 / ANP32A, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human PHAP1 / ANP32A
Product Gene Name
anti-PHAP1 antibody
Product Synonym Gene Name
ANP32A
Product Synonym Names
Anti-PHAP1 / ANP32A Antibody (N-Terminus) IHC-plus; ANP32A; Hepatopoietin Cn; I1PP2A; LANP; HPPCn; PHAP1; PHAPI; MAPM; PP32; C15orf1; Mapmodulin; Human PHAP1; ANP32A
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Synthetic peptide corresponding to amino acids at amino terminus of human PHAP
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
28,585 Da
OMIM
600832
3D Structure
ModBase 3D Structure for P39687
Target Species
Human
Immunogen Description
Synthetic peptide from human ANP32A.
Immunogen Type
Synthetic peptide
Immunogen
PHAP1 / ANP32A antibody was raised against synthetic peptide from human ANP32A.
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-PHAP1 antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB), ELISA (EIA)
Application Notes for anti-PHAP1 antibody
ELISA, ICC (1 ug/ml), IHC-P (5 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-PHAP1 antibody

Anti-ANP32A antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-PHAP1 Polyclonal Antibody – Cat# MBS243932

Immunohistochemistry (IHC) of anti-PHAP1 antibody

Anti-ANP32A antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-PHAP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243932

Immunohistochemistry (IHC) of anti-PHAP1 antibody

Anti-ANP32A antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-PHAP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243932

Immunocytochemistry (ICC) of anti-PHAP1 antibody

Immunocytochemistry of PHAP in Raji cells with PHAP antibody at 1 µg/ml.
Rabbit Anti-PHAP1 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS243932

Western Blot (WB) of anti-PHAP1 antibody

Western blot of PHAP expression in human Raji cell lysate with PHAP antibody at 1 ug/ml. The wide and strong band below PHAP III is a double let composed of PHAP I (upper) and PHAP I2a (lower).
Rabbit Anti-PHAP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS243932

Other Notes

Small volumes of anti-PHAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PHAP1 purchase

MBS243932 is an antibody targeting PHAP1. Also known as Rabbit Polyclonal to Human PHAP1 / ANP32A. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PHAP1. It may not necessarily be applicable to this product.

NCBI GI #
5453880
NCBI GeneID
8125
NCBI Accession #
NP_006296.1
UniProt Primary Accession #
P39687
UniProt Secondary Accession #
Q53FK4; Q5J8L8; Q7M4N6; B2R6T4
UniProt Related Accession #
P39687
GenBank Nucleotide #
NM_006305.3
NCBI Official Full Name
acidic leucine-rich nuclear phosphoprotein 32 family member A
NCBI Official Synonym Full Names
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
NCBI Official Symbol
ANP32A
NCBI Official Synonym Symbols
LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1
UniProt Protein Name
Acidic leucine-rich nuclear phosphoprotein 32 family member A
UniProt Synonym Protein Names
Acidic nuclear phosphoprotein pp32; pp32; Leucine-rich acidic nuclear protein; LANP; Mapmodulin; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; Putative HLA-DR-associated protein I; PHAPI
UniProt Gene Name
ANP32A
UniProt Synonym Gene Names
C15orf1; LANP; MAPM; PHAP1; pp32; LANP; PHAPI
UniProt Entry Name
AN32A_HUMAN
NCBI Protein Information
acidic leucine-rich nuclear phosphoprotein 32 family member A; mapmodulin; hepatopoietin Cn; acidic nuclear phosphoprotein pp32; leucine-rich acidic nuclear protein; putative HLA-DR-associated protein I; inhibitor-1 of protein phosphatase-2A; cerebellar leucine rich acidic nuclear protein; putative human HLA class II associated protein I; potent heat-stable protein phosphatase 2A inhibitor I1PP2A

UniProt Comments for PHAP1

ANP32A: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. Belongs to the ANP32 family.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: nucleoplasm; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleocytoplasmic transport; gene expression
Show more

Research Articles on PHAP1

1. Demonstrate that HPPCn attenuated oxidative injury and fibrosis induced by ethanol feeding and that the SphK1/S1P/S1PRs signalling pathway contributes to this protective effect.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PHAP1 antibody

 Reference Product  PubMed Publications
 SET antibody  >17 publications with PHAP1 and SET
 ELAVL1 antibody  >5 publications with PHAP1 and ELAVL1
 MAP1B antibody  >1 publications with PHAP1 and MAP1B
 ATXN1 antibody  >1 publications with PHAP1 and ATXN1

Pathways associated with anti-PHAP1 antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HuR Stabilizes MRNA Pathway antibodies  HuR Stabilizes MRNA Pathway Diagram
 Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway antibodies  Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway Diagram

Diseases associated with anti-PHAP1 antibody

 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >4 publications with PHAP1 and Cell Transformation, Neoplastic
 Ataxia Antibodies  >4 publications with PHAP1 and Ataxia
 Adenocarcinoma Antibodies  >2 publications with PHAP1 and Adenocarcinoma
 Liver Diseases Antibodies  >2 publications with PHAP1 and Liver Diseases
 Prostatic Diseases Antibodies  >2 publications with PHAP1 and Prostatic Diseases
 Liver Neoplasms Antibodies  >2 publications with PHAP1 and Liver Neoplasms
 Necrosis Antibodies  >2 publications with PHAP1 and Necrosis
 Gastrointestinal Diseases Antibodies  >1 publications with PHAP1 and Gastrointestinal Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with PHAP1 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >1 publications with PHAP1 and Inflammation

Organs/Tissues associated with anti-PHAP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with PHAP1 and Brain
 Nerve Antibodies  >14 publications with PHAP1 and Nerve
 Prostate Antibodies  >7 publications with PHAP1 and Prostate
 Blood Antibodies  >5 publications with PHAP1 and Blood
 Kidney Antibodies  >4 publications with PHAP1 and Kidney
 Liver Antibodies  >3 publications with PHAP1 and Liver
 Spleen Antibodies  >3 publications with PHAP1 and Spleen
 Ovary Antibodies  >3 publications with PHAP1 and Ovary
 Pituitary Gland Antibodies  >2 publications with PHAP1 and Pituitary Gland
 Pancreas Antibodies  >2 publications with PHAP1 and Pancreas
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000