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PAR-1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243933

MARK2 (EMK1), a MARK type protein kinase, has been implicated in regulating polarity, cell cycle progression, and microtubule dynamics. Specifically, it is reported to phosphorylate a MAP4-related protein in vitro. EMK(-/-) mice display growth retardation and… More details

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Product Overview

Online Datasheet in PDF
Product Name
PAR-1 / MARK2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human PAR-1 / MARK2
Product Gene Name
anti-PAR-1 antibody
Product Synonym Gene Name
MARK2
Product Synonym Names
Anti-PAR-1 / MARK2 Antibody (aa562-611) IHC-plus; MARK2; ELKL motif kinase 1; EMK-1; ELKL motif kinase; EMK1; PAR-1; PAR1 homolog; Par1b; Par-1b; Ser/Thr protein kinase PAR-1B; Emk; PAR1 homolog b; Human PAR-1; MARK2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
MARK2 Antibody detects endogenous levels of total MARK2 protein.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
81,209 Da
OMIM
600526
3D Structure
ModBase 3D Structure for Q7KZI7
Target Species
Human
Immunogen Description
Synthetic peptide from human MARK2 (aa562-611).
Immunogen
PAR-1 / MARK2 antibody was raised against synthetic peptide from human MARK2 (aa562-611).
Antigen Modification
aa562-611

Product Categories/Family for anti-PAR-1 antibody

Family: Protein Kinase; Subfamily: MARK
Applications Tested/Suitable for anti-PAR-1 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-PAR-1 antibody
ELISA (1:5000), IF (1:100 - 1:500), IHC-P (10 ug/ml)

Immunohistochemistry (IHC) of anti-PAR-1 antibody

Anti-MARK2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-PAR-1 Polyclonal Antibody – Cat# MBS243933

Immunofluorescence (IF) of anti-PAR-1 antibody

Immunofluorescence of HUVEC cells, using MARK2 antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-PAR-1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS243933

Other Notes

Small volumes of anti-PAR-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PAR-1 purchase

MBS243933 is an antibody targeting PAR-1. Also known as Rabbit Polyclonal (IgG) to Human PAR-1 / MARK2. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PAR-1. It may not necessarily be applicable to this product.

NCBI GI #
86990441
NCBI GeneID
2011
NCBI Accession #
NP_059672.2
UniProt Primary Accession #
Q7KZI7
UniProt Secondary Accession #
Q15449; Q15524; Q5XGA3; Q68A18; Q96HB3; Q96RG0
UniProt Related Accession #
Q7KZI7
GenBank Nucleotide #
NM_017490.3
NCBI Official Full Name
serine/threonine-protein kinase MARK2 isoform a
NCBI Official Synonym Full Names
MAP/microtubule affinity-regulating kinase 2
NCBI Official Symbol
MARK2
NCBI Official Synonym Symbols
EMK1; EMK-1; PAR-1; Par1b; Par-1b
UniProt Protein Name
Serine/threonine-protein kinase MARK2
UniProt Synonym Protein Names
ELKL motif kinase 1; EMK-1; MAP/microtubule affinity-regulating kinase 2; PAR1 homolog; PAR1 homolog b; Par-1b; Par1b
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
MARK2
UniProt Synonym Gene Names
EMK-1; Par-1b; Par1b
UniProt Entry Name
MARK2_HUMAN
NCBI Protein Information
serine/threonine-protein kinase MARK2; PAR1 homolog b; ELKL motif kinase 1; Ser/Thr protein kinase PAR-1B; serine/threonine protein kinase EMK

NCBI Summary for PAR-1

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
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UniProt Comments for PAR-1

MARK2: a CAMK protein kinase of the CAMKL group. Plays a role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection. 12 isoforms of the human protein are produced by alternative promoter.

Protein type: Kinase, protein; Protein kinase, CAMK; EC 2.7.11.26; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CAMK group; CAMKL family; MARK subfamily

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: mitochondrion; membrane; plasma membrane; actin filament; nucleus; basal cortex; lateral plasma membrane

Molecular Function: protein serine/threonine kinase activity; protein binding; tau-protein kinase activity; magnesium ion binding; lipid binding; protein kinase activator activity; ATP binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; Wnt receptor signaling pathway; establishment of cell polarity; protein amino acid autophosphorylation; neuron migration; peptidyl-threonine phosphorylation; activation of protein kinase activity; mitochondrion degradation; mitochondrion localization; regulation of axonogenesis; protein amino acid phosphorylation; regulation of cytoskeleton organization and biogenesis
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Research Articles on PAR-1

1. Phosphorylation of RNF41 by Par-1b regulates basolateral membrane targeting of laminin-111 receptors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PAR-1 antibody

 Reference Product  PubMed Publications
 MARK4 antibody  >51 publications with PAR-1 and MARK4
 STK11 antibody  >8 publications with PAR-1 and STK11
 ARHGEF2 antibody  >2 publications with PAR-1 and ARHGEF2
 KIAA0802 antibody  >1 publications with PAR-1 and KIAA0802

Pathways associated with anti-PAR-1 antibody

 Products by Pathway  Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Regulation Of Microtubule Cytoskeleton Pathway antibodies  Regulation Of Microtubule Cytoskeleton Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram

Diseases associated with anti-PAR-1 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >17 publications with PAR-1 and Carcinoma
 Immune System Diseases Antibodies  >16 publications with PAR-1 and Immune System Diseases
 Inflammation Antibodies  >9 publications with PAR-1 and Inflammation
 Cardiovascular Diseases Antibodies  >9 publications with PAR-1 and Cardiovascular Diseases
 Necrosis Antibodies  >6 publications with PAR-1 and Necrosis
 Adenocarcinoma Antibodies  >5 publications with PAR-1 and Adenocarcinoma
 Stroke Antibodies  >5 publications with PAR-1 and Stroke
 Fatty Liver Antibodies  >4 publications with PAR-1 and Fatty Liver
 Liver Diseases Antibodies  >4 publications with PAR-1 and Liver Diseases
 Kidney Diseases Antibodies  >3 publications with PAR-1 and Kidney Diseases

Organs/Tissues associated with anti-PAR-1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >48 publications with PAR-1 and Brain
 Blood Antibodies  >44 publications with PAR-1 and Blood
 Kidney Antibodies  >20 publications with PAR-1 and Kidney
 Muscle Antibodies  >15 publications with PAR-1 and Muscle
 Heart Antibodies  >15 publications with PAR-1 and Heart
 Liver Antibodies  >13 publications with PAR-1 and Liver
 Vascular Antibodies  >12 publications with PAR-1 and Vascular
 Nerve Antibodies  >12 publications with PAR-1 and Nerve
 Lung Antibodies  >11 publications with PAR-1 and Lung
 Bone Antibodies  >10 publications with PAR-1 and Bone
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