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P2RY4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243988

The pyrimidinergic receptor P2Y4 (P2RY4) is a member of the Purinergic Receptor subfamily. Membrane-bound P2 receptors mediate the actions of extracellular nucleotides in cell-to-cell signaling. More details

$650 / 0.05 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
P2RY4 / P2Y4, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human P2RY4 / P2Y4
Product Gene Name
anti-P2RY4 antibody
Product Synonym Gene Name
P2Y4
Product Synonym Names
Anti-P2RY4 / P2Y4 Antibody (Extracellular Domain) IHC-plus; P2RY4; p2Y4; p2P; p2Y purinoceptor 4; Pyrimidinergic receptor p2ry4; NRU; Uridine nucleotide receptor; p2RY4; UNR; Human P2RY4; P2Y4
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human P2RY4 / P2Y4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
40,963 Da
OMIM
300038
3D Structure
ModBase 3D Structure for P51582
Target Species
Human
Immunogen Description
Synthetic 15 amino acid peptide from 2nd extracellular domain of human P2RY4 / P2Y4. Percent identity with other species by BLAST analysis: Human (100%); Gorilla (93%); Monkey, Hamster, Bovine, Pig (80%).
Immunogen Type
Synthetic peptide
Immunogen
P2RY4 / P2Y4 antibody was raised against synthetic 15 amino acid peptide from 2nd extracellular domain of human P2RY4 / P2Y4. Percent identity with other species by BLAST analysis: Human (100%); Gorilla (93%); Monkey, Hamster, Bovine, Pig (80%).
Antigen Modification
Extracellular Domain

Product Categories/Family for anti-P2RY4 antibody

Family: GPCR; Subfamily: Purinergic
Applications Tested/Suitable for anti-P2RY4 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-P2RY4 antibody
IHC-P (6 ug/ml)

Immunohistochemistry (IHC) of anti-P2RY4 antibody

Anti-P2RY4 / P2Y4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-P2RY4 Polyclonal Antibody – Cat# MBS243988

Immunohistochemistry (IHC) of anti-P2RY4 antibody

Anti-P2RY4 / P2Y4 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-P2RY4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243988

Immunohistochemistry (IHC) of anti-P2RY4 antibody

Anti-P2RY4 / P2Y4 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-P2RY4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243988

Other Notes

Small volumes of anti-P2RY4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for P2RY4 purchase

MBS243988 is an antibody targeting P2RY4. Also known as Rabbit Polyclonal to Human P2RY4 / P2Y4. Reactive in Human
Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for P2RY4. It may not necessarily be applicable to this product.

NCBI GI #
4505561
NCBI GeneID
5030
NCBI Accession #
NP_002556.1
UniProt Primary Accession #
P51582
UniProt Secondary Accession #
Q4VBB7; Q4VBB8; Q502W2; Q5JT22
UniProt Related Accession #
P51582
GenBank Nucleotide #
NM_002565.3
NCBI Official Full Name
P2Y purinoceptor 4
NCBI Official Synonym Full Names
pyrimidinergic receptor P2Y, G-protein coupled, 4
NCBI Official Symbol
P2RY4
NCBI Official Synonym Symbols
NRU; P2P; UNR; P2Y4
UniProt Protein Name
P2Y purinoceptor 4
UniProt Synonym Protein Names
P2P; Uridine nucleotide receptor; UNR
Protein Family
P2Y purinoceptor
UniProt Gene Name
P2RY4
UniProt Synonym Gene Names
NRU; P2Y4; UNR
UniProt Entry Name
P2RY4_HUMAN
NCBI Protein Information
P2Y purinoceptor 4; uridine nucleotide receptor

NCBI Summary for P2RY4

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]
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UniProt Comments for P2RY4

P2RY4: Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xq13

Cellular Component: integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: purinergic nucleotide receptor activity, G-protein coupled; UTP-activated nucleotide receptor activity; ATP binding; uridine nucleotide receptor activity

Biological Process: elevation of cytosolic calcium ion concentration; transepithelial chloride transport; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
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Research Articles on P2RY4

1. reflected in the immunoblotting data P2RY4 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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