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HCAR3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243990

MBS243990 is an antibody targeting HCAR3. Also known as Rabbit Polyclonal to Human HCAR3 / GPR109B / HM74. Reactive in Gorilla, Human. Host: Rabbit. NIACR2 is a Nicotinic Acid GPCR. More details

$630 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HCAR3 / GPR109B / HM74, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human HCAR3 / GPR109B / HM74
Product Gene Name
Product Synonym Gene Name
GPR109B; HM74
Product Synonym Names
Anti-HCAR3 / GPR109B / HM74 Antibody (N-Terminus) IHC-plus; HCAR3; GPR109B; GTP-binding protein; NIACR2; HM74; HM74b; Nicotinic acid receptor 2; Putative chemokine receptor; Niacin receptor 2; Puma-g; HCA3; PUMAG; Human HCAR3; GPR109B; HM74
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gorilla, Human
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human GPR109B / HM74. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except HCAR2 (100%).
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
44,478 Da
OMIM
606039
3D Structure
ModBase 3D Structure for P49019
Target Species
Human
Immunogen Description
Synthetic 18 amino acid peptide from N-terminal extracellular domain of human GPR109B / HM74. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Panda (89%).
Immunogen Type
Synthetic peptide
Immunogen
HCAR3 / GPR109B / HM74 antibody was raised against synthetic 18 amino acid peptide from N-terminal extracellular domain of human GPR109B / HM74. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Panda (89%).
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-HCAR3 antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC)
Application Notes for anti-HCAR3 antibody
ICC, IHC-P (3 - 4 ug/ml)

Immunohistochemistry (IHC) of anti-HCAR3 antibody

Anti-GPR109B / HM74 antibody IHC of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3-4 ug/ml.
Rabbit Anti-HCAR3 Polyclonal Antibody – Cat# MBS243990

Immunohistochemistry (IHC) of anti-HCAR3 antibody

Anti-GPR109B / HM74 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3-4 ug/ml.
Rabbit Anti-HCAR3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS243990

Other Notes

Small volumes of anti-HCAR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HCAR3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
hydroxycarboxylic acid receptor 3
NCBI Official Synonym Full Names
hydroxycarboxylic acid receptor 3
NCBI Official Symbol
HCAR3
NCBI Official Synonym Symbols
HCA3; HM74; PUMAG; Puma-g; GPR109B
UniProt Protein Name
Hydroxycarboxylic acid receptor 3
UniProt Synonym Protein Names
G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; Niacin receptor 2; Nicotinic acid receptor 2
UniProt Gene Name
HCAR3
UniProt Synonym Gene Names
GPR109B; HCA3; HM74B; NIACR2
UniProt Entry Name
HCAR3_HUMAN
NCBI Protein Information
hydroxycarboxylic acid receptor 3; niacin receptor 2; GTP-binding protein; nicotinic acid receptor 2; putative chemokine receptor; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; hydroxy-carboxylic acid receptor 3

UniProt Comments for HCAR3

GPR109B: Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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