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FIS1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243992

MBS243992 is an antibody targeting FIS1. Also known as Rabbit Polyclonal (IgG) to Human FIS1. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
FIS1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human FIS1
Product Gene Name
anti-FIS1 antibody
Product Synonym Names
Anti-FIS1 Antibody (aa11-25) IHC-plus; FIS1; CGI-135; FIS1 homolog; HFis1; TPR repeat protein 11; TTC11; H_NH0132A01.6; Human FIS1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS containing 0.05% BSA and 0.05% sodium azide
Purity/Purification
Unpurified serum
Specificity
A peptide corresponding to amino acids 11-25 of human Fis1 protein was used as the immunogen.
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
Molecular Weight
16,938 Da
OMIM
609003
3D Structure
ModBase 3D Structure for Q9Y3D6
Target Species
Human
Immunogen Description
Synthetic peptide from human FIS1.
Immunogen Type
Synthetic peptide
Immunogen
FIS1 antibody was raised against synthetic peptide from human FIS1.
Antigen Modification
aa11-25
Applications Tested/Suitable for anti-FIS1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-FIS1 antibody
IHC-P (5 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-FIS1 antibody

Anti-FIS1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-FIS1 Polyclonal Antibody – Cat# MBS243992

Western Blot (WB) of anti-FIS1 antibody

Western blot of Fis1 in A) HeLa and B) NIH 3T3 cell lysate using antibody at 1:1000 dilution.
Rabbit Anti-FIS1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS243992

Other Notes

Small volumes of anti-FIS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FIS1. It may not necessarily be applicable to this product.

NCBI GeneID
51024
NCBI Accession #
NP_057152.2
UniProt Primary Accession #
Q9Y3D6
UniProt Secondary Accession #
Q9BTP3
UniProt Related Accession #
Q9Y3D6
NCBI Official Full Name
mitochondrial fission 1 protein
NCBI Official Synonym Full Names
fission, mitochondrial 1
NCBI Official Symbol
FIS1
NCBI Official Synonym Symbols
TTC11; CGI-135
UniProt Protein Name
Mitochondrial fission 1 protein
UniProt Synonym Protein Names
FIS1 homolog; hFis1; Tetratricopeptide repeat protein 11; TPR repeat protein 11
Protein Family
Mitochondria fission 1 protein
UniProt Gene Name
FIS1
UniProt Synonym Gene Names
TTC11; hFis1; TPR repeat protein 11
UniProt Entry Name
FIS1_HUMAN
NCBI Protein Information
mitochondrial fission 1 protein

NCBI Summary for FIS1

The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]

UniProt Comments for FIS1

FIS1: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family.

Protein type: Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: integral to peroxisomal membrane; protein complex; membrane; mitochondrion; peroxisome; integral to mitochondrial outer membrane

Molecular Function: protein binding; receptor binding

Biological Process: peroxisome fission; mitochondrial fission; elevation of cytosolic calcium ion concentration; release of cytochrome c from mitochondria; mitochondrial fusion; reduction of endoplasmic reticulum calcium ion concentration; mitochondrion degradation; positive regulation of caspase activity; mitochondrial fragmentation during apoptosis; protein targeting to mitochondrion; protein homooligomerization; elevation of mitochondrial calcium ion concentration
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Research Articles on FIS1

1. Study revealed that a novel mitochondrial fission pathway composed of miR-483-5p and FIS1 regulates cisplatin sensitivity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FIS1 antibody

 Reference Product  PubMed Publications
 MFN1 antibody  >46 publications with FIS1 and MFN1
 MFN2 antibody  >44 publications with FIS1 and MFN2
 DNM1L antibody  >40 publications with FIS1 and DNM1L
 PEX11A antibody  >6 publications with FIS1 and PEX11A
 BCAP31 antibody  >3 publications with FIS1 and BCAP31
 PEX11B antibody  >3 publications with FIS1 and PEX11B
 GDAP1 antibody  >2 publications with FIS1 and GDAP1
 PEX11G antibody  >1 publications with FIS1 and PEX11G
 MARCH5 antibody  >1 publications with FIS1 and MARCH5

Diseases associated with anti-FIS1 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >54 publications with FIS1 and Death
 Nervous System Diseases Antibodies  >31 publications with FIS1 and Nervous System Diseases
 Heart Diseases Antibodies  >8 publications with FIS1 and Heart Diseases
 Movement Disorders Antibodies  >5 publications with FIS1 and Movement Disorders
 Heart Failure Antibodies  >4 publications with FIS1 and Heart Failure
 Inflammation Antibodies  >4 publications with FIS1 and Inflammation
 Necrosis Antibodies  >4 publications with FIS1 and Necrosis
 Hypertrophy Antibodies  >3 publications with FIS1 and Hypertrophy
 Weight Loss Antibodies  >3 publications with FIS1 and Weight Loss
 Edema Antibodies  >2 publications with FIS1 and Edema

Organs/Tissues associated with anti-FIS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >28 publications with FIS1 and Muscle
 Brain Antibodies  >27 publications with FIS1 and Brain
 Heart Antibodies  >16 publications with FIS1 and Heart
 Blood Antibodies  >8 publications with FIS1 and Blood
 Vascular Antibodies  >8 publications with FIS1 and Vascular
 Lung Antibodies  >7 publications with FIS1 and Lung
 Liver Antibodies  >6 publications with FIS1 and Liver
 Pancreas Antibodies  >3 publications with FIS1 and Pancreas
 Prostate Antibodies  >3 publications with FIS1 and Prostate
 Adipose Tissue Antibodies  >3 publications with FIS1 and Adipose Tissue
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